Výsledky vyhledávání - "M K, Yunmbam"

Lactacystin enhances cisplatin sensitivity in resistant human ovarian cancer cell lines via inhibition of DNA repair and ERCC-1 expression

Autor: Q Q, Li, M K, Yunmbam, X, Zhong, J J, Yu, E G, Mimnaugh, L, Neckers, E, Reed

Publikováno v: Cellular and molecular biology (Noisy-le-Grand, France).

Cisplatin is among the most effective chemotherapeutic agents in the treatment of human ovarian cancer. The cytotoxicity of cisplatin results primarily from its ability to bind covalently to DNA and prevent DNA replication and transcription. The ubiq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ca25747f2c9ecbb292ad1818ab4fa593
https://pubmed.ncbi.nlm.nih.gov/11936875

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The bacterial polysaccharide tecogalan blocks growth of breast cancer cells in vivo

Autor: M K, Yunmbam, A, Wellstein

Publikováno v: Oncology reports. 8(1)

The growth of supportive tissue during the progression of solid tumors is an absolute requirement for the nourishment of the tumor. The blockade of this proliferative response of normal tissues to the growing tumor should hence inhibit tumor progress

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f6943cd508039b521739af05d398e21b
https://pubmed.ncbi.nlm.nih.gov/11115590

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Association between the level of ERCC-1 expression and the repair of cisplatin-induced DNA damage in human ovarian cancer cells

Autor: Q, Li, J J, Yu, C, Mu, M K, Yunmbam, D, Slavsky, C L, Cross, F, Bostick-Bruton, E, Reed

Publikováno v: Anticancer research. 20(2A)

Nucleotide excision repair (NER) is responsible for the repair of platinum-DNA lesions. ERCC-1 is a critical gene within the NER pathway, and cells without a functional ERCC-1 do not repair cisplatin-caused DNA damage. The present study was therefore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8dd10d2c69c0c9d94f06c477ca841158
https://pubmed.ncbi.nlm.nih.gov/10810335

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Phase I trial of orally administered pentosan polysulfate in patients with advanced cancer

Autor: J L, Marshall, A, Wellstein, J, Rae, R J, DeLap, K, Phipps, J, Hanfelt, M K, Yunmbam, J X, Sun, K L, Duchin, M J, Hawkins

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 3(12 Pt 1)

Tumor angiogenesis is critically important to tumor growth and metastasis. We have shown that pentosan polysulfate (PPS) is an effective inhibitor of heparin-binding growth factors in vitro and can effectively inhibit the establishment and growth of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9bc2511edb9c9a7c58ac9b67785ebb7b
https://pubmed.ncbi.nlm.nih.gov/9815633

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