Zobrazeno 1 - 10
of 25
pro vyhledávání: '"M K, Spriggs"'
Autor:
J Müllberg, Terry Farrah, Jeffrey I. Cohen, B M Macduff, D. Ulrich, Laura Strockbine, Mark R. Alderson, Richard J. Armitage, M K Spriggs, Michael R. Comeau
Publikováno v:
Journal of Virology. 70:5557-5563
The Epstein-Barr virus BZLF2 gene encodes a glycoprotein that associates with gH and gL and facilitates the infection of B lymphocytes. In order to determine whether the BZLF2 protein recognizes a B-cell-specific surface antigen, a soluble protein co
Publikováno v:
The Journal of Immunology. 155:5483-5486
A cDNA encoding human IL-17 (hIL-17) was cloned from a CD4+ T cell library. The predicted 155-amino acids sequence contains an N-terminal signal peptide and exhibits 72% amino acid identity with HVS13, an open reading frame from a T-lymphotropic Herp
Publikováno v:
The Journal of Immunology. 152:4262-4269
Murine and human CD40 ligand (CD40L) were recently cloned, expressed, and shown to possess potent activity on human and murine B cells, including stimulation of proliferation and Ig secretion in the presence of cytokines. In addition to its action on
Autor:
J J Westendorf, G J Ahmann, R J Armitage, M K Spriggs, J A Lust, P R Greipp, J A Katzmann, D F Jelinek
Publikováno v:
The Journal of Immunology. 152:117-128
Myeloma is a neoplasia characterized by the accumulation of malignant plasma cells in the bone marrow. In these studies, we have demonstrated that CD40 is expressed in human myeloma cells and have used a recently established IL-6-dependent myeloma ce
Publikováno v:
The Journal of Experimental Medicine
CD40 is a member of the tumor necrosis factor (TNF) receptor family of cell surface proteins and was originally described as a B cell restricted antigen. Treatment of primary human monocytes with granulocyte/macrophage colony-stimulating factor (GM-C
Autor:
W C, Fanslow, M K, Spriggs, C T, Rauch, K N, Clifford, B M, Macduff, S F, Ziegler, K A, Schooley, K M, Mohler, C J, March, R J, Armitage
Publikováno v:
Blood. 81:2998-3005
Biotinylated interleukin-4 (IL-4) was used to examine IL-4 receptor (IL- 4R) expression on a range of human B-cell lines by flow cytometry. Using high concentrations of biotinylated IL-4, we have identified a novel low-affinity IL-4 receptor expresse
Publikováno v:
The Journal of Immunology. 150:3671-3680
Recombinant human CD40 ligand (hCD40L) was expressed on the surface of CV1/EBNA cells and examined for its ability to induce proliferation and Ig secretion from human B cells in the presence or absence of soluble cytokines. hCD40L was directly mitoge
Autor:
K H Grabstein, C R Maliszewski, K Shanebeck, T A Sato, M K Spriggs, W C Fanslow, R J Armitage
Publikováno v:
The Journal of Immunology. 150:3141-3147
Our study demonstrates the central role for the murine CD40 ligand and IL-2 in contact-dependent T cell help for Ag-specific primary antibody responses in vitro. Helper T cell clones were found to express CD40 ligand after activation with CD3 mAb. Me
Publikováno v:
Journal of Biological Chemistry. 268:2513-2524
Interleukin (IL)-1 refers to a group of three polypeptide hormones with a wide range of cellular targets. Two types of IL-1 receptor have been identified and characterized by cDNA cloning. Both human type I and type II IL-1 receptors contain extracel
Publikováno v:
Scopus-Elsevier
Primary human monocytes and the human monocytic cell line THP-1 were induced to express receptors for interleukin-1 alpha (IL-1 alpha) and IL-1 beta. Treatment of primary monocytes with dexamethasone resulted in a 10-fold increase in receptor number