Zobrazeno 1 - 10 of 23 pro vyhledávání: '"M K, Bijsterbosch"'
1
Interactions of lipid-oligonucleotide conjugates with low-density lipoprotein
Autor: E T, Rump, E A, Biessen, T J, van Berkel, M K, Bijsterbosch
Publikováno v: Methods in molecular medicine. 65
The ability of antisense oligonucleotides to interdict, sequence-specifically, the expression of pathogenic genes affords an exciting new strategy for therapeutic intervention (1-3). Oligonucleotides with physiological phosphodiester internucleotide
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2a196057dd3703cff4f63bc6e5970e39
https://pubmed.ncbi.nlm.nih.gov/21318747
Zobrazit plný text záznamu
2
Midazolam is a phenobarbital-like cytochrome p450 inducer in rats
Autor: P A, Hoen, M K, Bijsterbosch, T J, van Berkel, N P, Vermeulen, J N, Commandeur
Publikováno v: The Journal of pharmacology and experimental therapeutics. 299(3)
Midazolam is almost exclusively metabolized by cytochrome P450 3A (CYP3A) isoenzymes. Therefore, midazolam is used as a probe to determine CYP3A levels in humans and rats. A prerequisite for longitudinal determination of CYP3A expression levels using
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d2e3f3be406365de25e08a40a886bbdc
https://pubmed.ncbi.nlm.nih.gov/11714877
Zobrazit plný text záznamu
3
Delivery of cholesteryl-conjugated phosphorothioate oligodeoxynucleotides to Kupffer cells by lactosylated low-density lipoprotein
Autor: M K, Bijsterbosch, M, Manoharan, R, Dorland, I H, Waarlo, E A, Biessen, T J, van Berkel
Publikováno v: Biochemical pharmacology. 62(5)
The efficacy of antisense oligonucleotides depends on the ability to reach in vivo their target cells. We aim to develop strategies to enhance uptake of phosphorothioate oligodeoxynucleotides by Kupffer cells. To this end, we conjugated cholesterol t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::801f34e389f80363607657b1db9c99ac
https://pubmed.ncbi.nlm.nih.gov/11585059
Zobrazit plný text záznamu
4
Carrier-mediated delivery improves the efficacy of 9-(2-phosphonylmethoxyethyl)adenine against hepatitis B virus
Autor: M K, Bijsterbosch, C, Ying, R L, de Vrueh, E, de Clercq, E A, Biessen, J, Neyts, T J, van Berkel
Publikováno v: Molecular pharmacology. 60(3)
We recently synthesized a lipophilic prodrug of 9-(2-phosphonyl-methoxyethyl)adenine (PMEA), designated PMEA-LO, and incorporated it into reconstituted lactosylated high-density lipoprotein (LacNeoHDL). In a rat model, LacNeoHDL-associated PMEA-LO wa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::565a00566947c3892ff338a40177270a
https://pubmed.ncbi.nlm.nih.gov/11502883
Zobrazit plný text záznamu
6
Selective induction of cytochrome P450 3A1 by dexamethasone in cultured rat hepatocytes: analysis with a novel reverse transcriptase-polymerase chain reaction assay section sign
Autor: P A, Hoen, J N, Commandeur, N P, Vermeulen, T J, Van Berkel, M K, Bijsterbosch
Publikováno v: Biochemical pharmacology. 60(10)
The study of drug metabolism in cultured rat hepatocytes is hampered by the rapid loss of the expression of cytochrome P450 enzymes. Nevertheless, the activity of cytochrome P450 3A (CYP3A), one of the most important isoenzymes for drug metabolism, c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c4ce1ca98b10215709644393f8a90fe1
https://pubmed.ncbi.nlm.nih.gov/11020454
Zobrazit plný text záznamu
8
Synthesis of a lipophilic prodrug of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and its incorporation into a hepatocyte-specific lipidic carrier
Autor: R L, de Vrueh, E T, Rump, L A, Sliedregt, E A, Biessen, T J, van Berkel, M K, Bijsterbosch
Publikováno v: Pharmaceutical research. 16(8)
9-(2-Phosphonylmethoxyethyl)adenine (PMEA), a potent inhibitor of Hepatitis B virus replication, is in vivo hardly taken up by parenchymal liver cells (the site of infection). Our aim is to examine whether lactosylated reconstituted HDL (LacNeoHDL),
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d8b4606b27a021ef242ff3ae4b20254d
https://pubmed.ncbi.nlm.nih.gov/10468017
Zobrazit plný text záznamu
9
Stable incorporation of a lipophilic daunorubicin prodrug into apolipoprotein E-exposing liposomes induces uptake of prodrug via low-density lipoprotein receptor in vivo
Autor: A J, Versluis, E T, Rump, P C, Rensen, T J, van Berkel, M K, Bijsterbosch
Publikováno v: The Journal of pharmacology and experimental therapeutics. 289(1)
Many tumors express elevated levels of low-density lipoprotein (LDL) receptors. Therefore, native LDL and synthetic LDL-like particles have been proposed as carriers for antineoplastic drugs. We demonstrated earlier that small apolipoprotein E (apoE)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3604499a7956a5e30f354b2bae0566e4
https://pubmed.ncbi.nlm.nih.gov/10086980
Zobrazit plný text záznamu
10
Synthesis of a lipophilic daunorubicin derivative and its incorporation into lipidic carriers developed for LDL receptor-mediated tumor therapy
Autor: A J, Versluis, E T, Rump, P C, Rensen, T J, Van Berkel, M K, Bijsterbosch
Publikováno v: Pharmaceutical research. 15(4)
Many tumors express elevated levels of LDL receptors (apoB, E receptors) on their membranes. Selective delivery of anti-neoplastic drugs to tumors by incorporation of these drugs into LDL or LDL-resembling particles should improve the efficacy of tum
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1330311d781fcdf8696c8ec2a02cd0d5
https://pubmed.ncbi.nlm.nih.gov/9587947
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje