Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation.

Autor: Muhammad S Alam, Matthias M Gaida, Subrata Debnath, Harichandra D Tagad, Lisa M Miller Jenkins, Ettore Appella, M Jubayer Rahman, Jonathan D Ashwell

Publikováno v: PLoS Biology, Vol 16, Iss 1, p e2004111 (2018)

Nuclear factor of activated T cells (NFAT) transcription factors are required for induction of T-cell cytokine production and effector function. Although it is known that activation via the T-cell antigen receptor (TCR) results in 2 critical steps, c

Externí odkaz: https://doaj.org/article/e18026c7426842a2b968df00dde7a2a2

Loss of Zbtb32 in NOD mice does not significantly alter T cell responses. [version 1; referees: 2 approved]

Autor: William D. Coley, Yongge Zhao, Charles J. Benck, Yi Liu, Chie Hotta-Iwamura, M. Jubayer Rahman, Kristin V Tarbell

Publikováno v: F1000Research, Vol 7 (2018)

Background: We previously identified the transcriptional regulator Zbtb32 as a factor that can promote T cell tolerance in the Non-Obese Diabetic (NOD) mouse, a model of Type 1 diabetes. Antigen targeted to DCIR2+ dendritic cells (DCs) in vivo inhibi

Externí odkaz: https://doaj.org/article/efdfaebe194741f09618cb787b4f24e1

List of Contributors

Autor: Jakub Abramson, S. Sohail Ahmed, Marco A. Alba, Youssif M. Ali, Julian L. Ambrus, Agnes Andersson Svärd, Martin Aringer, Shervin Assassi, Thanda Aung, Ilya Ayzenberg, Robert N. Barker, Alan G. Baxter, Corrado Betterle, Stanca A. Birlea, Niklas K. Björkström, Paul A. Blair, Stephan Blüml, Xavier Bosch, Robert A. Brodsky, Yenan T. Bryceson, Patrick R. Burkett, James B. Bussel, Roberto Caricchio, Livia Casciola-Rosen, Patrizio Caturegli, Benjamin Chaigne-Delalande, Paulina Chalan, Lucienne Chatenoud, Philip L. Cohen, Megan A. Cooper, Ken Coppieters, Ronald G. Crystal, Donna A. Culton, Valentina Damato, Anne Davidson, Lorenzo Delfino, Peter J. Delves, Giulia Di Dalmazi, Betty Diamond, Luis A. Diaz, Ronald J. Falk, Marvin J. Fritzler, Stefania Gallucci, Sapna Gangaputra, Brian Gelbman, M. Eric Gershwin, Igal Gery, Daniel R. Getts, Ralf Gold, Yael Goldfarb, Jing Gong, Siamon Gordon, Jörg J. Goronzy, Judith M. Greer, Vanesa A. Guazzone, Luiza Guilherme, David A. Hafler, Bevra H. Hahn, Abdel Rahim A. Hamad, Hideaki Hamano, Leonard C. Harrison, Dirk Homann, Eystein S. Husebye, J. Charles Jennette, Richard J. Jones, Margaret A. Jordan, Jorge Kalil, Shigeyuki Kawa, Ziya Kaya, Christian W. Keller, Nicholas J.C. King, Maleewan Kitcharoensakkul, Kendo Kiyosawa, Christoph Königs, Mitchell Kronenberg, Vijay K. Kuchroo, Arian Laurence, Eun-Ju Lee, Helmar C. Lehmann, Åke Lernmark, Ida Lindbladh, Zhi Liu, Hans-Gustaf Ljunggren, Claudio Lunardi, Knut E.A. Lundin, Jan D. Lünemann, Michael P.T. Lunn, Livia Lustig, Charles R. Mackay, Ian R. Mackay, Clara Malattia, Luisa Martinez-Pomares, Alberto Martini, Claudia Mauri, Pamela A. McCombe, Fritz Melchers, Giorgina Mieli-Vergani, Frederick W. Miller, Stephen D. Miller, Masayuki Mizui, Jenny Mjösberg, Christian Münz, Jagtar Singh Nijjar, David A. Norris, Kristine Oleinika, Joost J. Oppenheim, Mathias Pawlak, Cristina Peligero-Cruz, Anneli Peters, Pärt Peterson, Kalliopi Pitarokoili, Fabio Presotto, Antonio Puccetti, Hamid Rabb, Patricia Raczek, M. Jubayer Rahman, Manuel Ramos-Casals, Noel R. Rose, Antony Rosen, Mohanraj Sadasivam, Adam Schiffenbauer, Wilhelm J. Schwaeble, H. Nida Sen, Marc Serota, Kazim A. Sheikh, Yehuda Shoenfeld, Ora Shovman, Joachim Sieper, Arthur M. Silverstein, Robert B. Sim, Kenneth G C Smith, Josef S. Smolen, Ludvig M. Sollid, Alanna Spiteri, Lawrence Steinman, John H. Stone, Uta Syrbe, Ami Tamhaney, Atsushi Tanaka, Veena Taneja, Kristin V. Tarbell, Elisa Tinazzi, Benedict K. Tiong, Ban-Hock Toh, George C. Tsokos, Kenneth S.K. Tung, John Varga, Diego Vergani, Mark A. Vickers, Stuart Viegas, Angela Vincent, Matthias von Herrath, Anthony P. Weetman, Joel V. Weinstock, John M. Wentworth, Sarah Wesley, Cornelia M. Weyand, Gerhard Wingender, Michael W. Winter, Renato Zanchetta, Moncef Zouali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7089e3cc62afc3d1808e8be1b4adbc79
https://doi.org/10.1016/b978-0-12-812102-3.00078-6

Innate immune stimulation of whole blood reveals IFN-1 hyper-responsiveness in type 1 diabetes

Autor: Carla J. Greenbaum, Peter S. Linsley, Matthew J. Dufort, Cate Speake, Vincent Bondet, Darragh Duffy, Kameron B. Rodrigues, M. Jubayer Rahman, Alba Llibre, Kristin V. Tarbell, Juan Quiel

Publikováno v: Diabetologia
Diabetologia, Springer Verlag, 2020, ⟨10.1007/s00125-020-05179-4⟩
Diabetologia, 2020, ⟨10.1007/s00125-020-05179-4⟩

Self-antigen-specific T cell responses drive type 1 diabetes pathogenesis, but alterations in innate immune responses are also critical and not as well understood. Innate immunity in human type 1 diabetes has primarily been assessed via gene-expressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61dc6fa54e0d4c6ff16b6e17cea62de1
https://pubmed.ncbi.nlm.nih.gov/32500289

Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation

Autor: Matthias M Gaida, Jonathan D. Ashwell, Subrata Debnath, M. Jubayer Rahman, Muhammad S. Alam, Harichandra D. Tagad, Lisa M. Miller Jenkins, Ettore Appella

Publikováno v: PLoS Biology, Vol 16, Iss 1, p e2004111 (2018)
PLoS Biology

Nuclear factor of activated T cells (NFAT) transcription factors are required for induction of T-cell cytokine production and effector function. Although it is known that activation via the T-cell antigen receptor (TCR) results in 2 critical steps, c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757ad0e5eae485ee956a8277f4279526
https://doaj.org/article/e18026c7426842a2b968df00dde7a2a2