Výsledky vyhledávání - "M Jover-Cobos"

Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells

Autor: Alberto Quaglia, Antonio Bertoletti, Doreen A. Cantrell, Linda V. Sinclair, Kasha P. Singh, Giuseppe Fusai, Abhishek Das, Patrick T F Kennedy, Upkar S. Gill, Niclas Thomas, Antony Chen, Mala K. Maini, Laura J. Pallett, Nathan Davies, Muzlifah Haniffa, Anna Schurich, M Jover-Cobos

Publikováno v: Nature medicine

Infection with hepatitis B virus (HBV) results in disparate degrees of tissue injury: the virus can either replicate without pathological consequences or trigger immune-mediated necroinflammatory liver damage. We investigated the potential for myeloi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5784efaa11bebe06ad5d5accebf59e73
https://doi.org/10.1038/nm.3856

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Role of Toll-Like Receptor 4 in Mediating Multiorgan Dysfunction in Mice With Acetaminophen Induced Acute Liver Failure

Autor: Rajeshwar P. Mookerjee, Rajiv Jalan, Montserrat Montes de Oca, Masashi Muroi, N Shah, Dipok Kumar Dhar, Kei-ichi Sugiyama, Nathan Davies, M Jover-Cobos, Ken-ichi Tanamoto

Publikováno v: Liver Transplantation. 19:751-761

Strategies for the prevention of multiorgan dysfunction (MOD) in acetaminophen (APAP)-induced acute liver failure (ALF) are an unmet need. Our study tested the hypothesis that sterile inflammation induced by APAP in a mouse model would activate toll-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea4c9fc00f1bf4d907626d03715b38e1
https://doi.org/10.1002/lt.23655

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Ornithine phenylacetate revisited

Autor: Y Sharifi, Rajiv Jalan, L Noiret, M Jover-Cobos

Publikováno v: Metabolic Brain Disease. 28:327-331

In patients with liver failure hyperammonemia is associated with the development of hepatic encephalopathy (HE) and immune impairment. Treatment of hyperammonemia is an unmet clinical need. Ornithine phenylacetate (OP) is a novel drug that is targete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a6b687d6148863722f53198460fa11
https://doi.org/10.1007/s11011-013-9391-5

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Increased renal expression and urinary excretion of TLR4 in acute kidney injury associated with cirrhosis

Autor: R. P. Mookerjee, Valérie Paradis, N Shah, Rajiv Jalan, Kevin P. Moore, Jane Macnaughtan, Nathan Davies, F Mohamed, M Jover-Cobos, Richard Moreau

Publikováno v: Liver International. 33:398-409

Background Patients with cirrhosis frequently develop renal dysfunction, a proportion of who do not fulfill criteria for hepatorenal syndrome (HRS). We hypothesized that the kidneys in these patients would exhibit histological and biomarker evidence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff5eb6dcb63c0b6d093515e64988773
https://doi.org/10.1111/liv.12047

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Ornithine phenylacetate targets alterations in the expression and activity of glutamine synthase and glutaminase to reduce ammonia levels in bile duct ligated rats

Autor: Vikram Sharma, M Jover-Cobos, Manuel Romero-Gómez, Karla C. L. Lee, Nathan Davies, Rajiv Jalan, A Habtesion, L Noiret

Publikováno v: Journal of hepatology. 60(3)

Background & Aims In liver failure, ammonia homeostasis is dependent upon the function of the ammonia metabolising enzymes, glutamine synthetase (GS) and glutaminase (GA) but data about their protein expression and activity are lacking. The aims of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b511b125094e35ecdcbb3214c5cd58e8
https://pubmed.ncbi.nlm.nih.gov/24512823

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The Rise of Glutaminase in End-Stage Liver Diseases

Autor: M Jover-Cobos, Nathan Davies, Rajiv Jalan, Manuel Romero-Gómez

Publikováno v: Liver Transplantation-Basic Issues

Ammonia plays a major role in the pathogenesis of hepatic encephalopathy (HE). Systemic hyperammonemia has been largely found in patients with HE with underlying cirrhosis and acute liver failure. HE is associated with a poor prognosis of both acute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0902074d45ee0ed716b097e4e1e1ab6c
http://www.intechopen.com/articles/show/title/the-rise-of-glutaminase-in-end-stage-liver-diseases

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Ornithine Phenylacetate: A Novel Strategy for the Treatment of Hepatic Encephalopathy

Autor: M Jover-Cobos, Y Sharifi, Rajiv Jalan, Nathan Davies

Publikováno v: Hepatic Encephalopathy ISBN: 9781617798351

Over the past 100 years a central role of ammonia in the pathogenesis of hepatic encephalopathy (HE) has been hypothesized. Treatment of hyperammonemia and HE are unmet clinical needs. Ornithine phenylacetate (OP) is a novel drug that is targeted at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c5521cd7e26263f9af8e010e4f2430a
https://doi.org/10.1007/978-1-61779-836-8_13

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Prevention of acute kidney injury in a rodent model of cirrhosis following selective gut decontamination is associated with reduced renal TLR4 expression

Autor: Rajeshwar P. Mookerjee, N Shah, Steven W. M. Olde Damink, Dipok Kumar Dhar, Jane Macnaughtan, Nathan Davies, Rajiv Jalan, M Jover-Cobos, Fatma El Zahraa Mohammed, A Habtesion, Vikram Sharma

Publikováno v: Journal of Hepatology, 56(5), 1047-1053. Elsevier Science

BACKGROUND & AIMS: Superimposed infection and/or inflammation precipitate renal failure in cirrhosis. This study aimed at testing the hypothesis that increased gut bacterial translocation in cirrhosis primes the kidney to the effect of superimposed i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a599cf8595b2a706b90726ff34e5029
https://pubmed.ncbi.nlm.nih.gov/22266601

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