Zobrazeno 1 - 10
of 106
pro vyhledávání: '"M Joanne, Lemieux"'
Autor:
Pu Chen, Tayla J. Van Oers, Elena Arutyunova, Conrad Fischer, Chaoxiang Wang, Tess Lamer, Marco J. van Belkum, Howard S. Young, John C. Vederas, M. Joanne Lemieux
Publikováno v:
JACS Au, Vol 4, Iss 8, Pp 3217-3227 (2024)
Externí odkaz:
https://doaj.org/article/43087000c76649d4af843aa50a0189fd
Autor:
Elena Arutyunova, Alexandr Belovodskiy, Pu Chen, Muhammad Bashir Khan, Michael Joyce, Holly Saffran, Jimmy Lu, Zoe Turner, Bing Bai, Tess Lamer, Howard S. Young, John C. Vederas, D. Lorne Tyrrell, M. Joanne Lemieux, James A. Nieman
Publikováno v:
ACS Bio & Med Chem Au, Vol 3, Iss 6, Pp 528-541 (2023)
Externí odkaz:
https://doaj.org/article/b8e37dea5f004761a5ac48cc97ba66e2
Autor:
Yusuke Nasu, Ciaran Murphy-Royal, Yurong Wen, Jordan N. Haidey, Rosana S. Molina, Abhi Aggarwal, Shuce Zhang, Yuki Kamijo, Marie-Eve Paquet, Kaspar Podgorski, Mikhail Drobizhev, Jaideep S. Bains, M. Joanne Lemieux, Grant R. Gordon, Robert E. Campbell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
l-lactate is an important intercellular energy currency. Here the authors report a genetically encoded biosensor eLACCO1.1 to monitor extracellular l-lactate; they use eLACCO1.1 to image extracellular l-lactate in cultured mammalian cells and brain t
Externí odkaz:
https://doaj.org/article/56b5eb5b8e5543099fe7a7880622d7ac
Autor:
André L. A. Neves, Jiangkun Yu, Yutaka Suzuki, Marisol Baez-Magana, Elena Arutyunova, Eóin O’Hara, Tim McAllister, Kim H. Ominski, M. Joanne Lemieux, Le Luo Guan
Publikováno v:
Microbiome, Vol 9, Iss 1, Pp 1-16 (2021)
Abstract Background Carbohydrate-active enzymes (CAZymes) form the most widespread and structurally diverse set of enzymes involved in the breakdown, biosynthesis, or modification of lignocellulose that can be found in living organisms. However, the
Externí odkaz:
https://doaj.org/article/c16a0943fa1049f685c4114b526e2347
Autor:
Sheng-Yi Wu, Yurong Wen, Nelson B C Serre, Cathrine Charlotte Heiede Laursen, Andrea Grostøl Dietz, Brian R Taylor, Mikhail Drobizhev, Rosana S Molina, Abhi Aggarwal, Vladimir Rancic, Michael Becker, Klaus Ballanyi, Kaspar Podgorski, Hajime Hirase, Maiken Nedergaard, Matyáš Fendrych, M Joanne Lemieux, Daniel F Eberl, Alan R Kay, Robert E Campbell, Yi Shen
Publikováno v:
PLoS Biology, Vol 20, Iss 9, p e3001772 (2022)
Potassium ion (K+) plays a critical role as an essential electrolyte in all biological systems. Genetically-encoded fluorescent K+ biosensors are promising tools to further improve our understanding of K+-dependent processes under normal and patholog
Externí odkaz:
https://doaj.org/article/3acdec6eadb747dba6da2bd4ef33714b
Autor:
Jimmy Lu, Sizhu Amelia Chen, Muhammad Bashir Khan, Raelynn Brassard, Elena Arutyunova, Tess Lamer, Wayne Vuong, Conrad Fischer, Howard S. Young, John C. Vederas, M. Joanne Lemieux
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Coronaviruses infect a variety of hosts in the animal kingdom, and while each virus is taxonomically different, they all infect their host via the same mechanism. The coronavirus main protease (Mpro, also called 3CLpro), is an attractive target for d
Externí odkaz:
https://doaj.org/article/10bc0488429546de95a3dbd8df1e6b43
Autor:
Wayne Vuong, Muhammad Bashir Khan, Conrad Fischer, Elena Arutyunova, Tess Lamer, Justin Shields, Holly A. Saffran, Ryan T. McKay, Marco J. van Belkum, Michael A. Joyce, Howard S. Young, D. Lorne Tyrrell, John C. Vederas, M. Joanne Lemieux
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Coronavirus main protease is essential for viral polyprotein processing and replication. Here Vuong et al. report efficient inhibition of SARS-CoV-2 replication by the dipeptide-based protease inhibitor GC376 and its parent GC373, which were original
Externí odkaz:
https://doaj.org/article/3c902c5ef40f40398c856f91dffa7d74
Autor:
M'Lynn E Fisher, Elisa Bovo, Rodrigo Aguayo-Ortiz, Ellen E Cho, Marsha P Pribadi, Michael P Dalton, Nishadh Rathod, M Joanne Lemieux, L Michel Espinoza-Fonseca, Seth L Robia, Aleksey V Zima, Howard S Young
Publikováno v:
eLife, Vol 10 (2021)
The sarco-plasmic reticulum calcium pump (SERCA) plays a critical role in the contraction-relaxation cycle of muscle. In cardiac muscle, SERCA is regulated by the inhibitor phospholamban. A new regulator, dwarf open reading frame (DWORF), has been re
Externí odkaz:
https://doaj.org/article/87991ab8aa184f75a15e117bb6842178
Autor:
Monica X. Li, Shorena Gelozia, Gaddafi I. Danmaliki, Yurong Wen, Philip B. Liu, M. Joanne Lemieux, Frederick G. West, Brian D. Sykes, Peter M. Hwang
Publikováno v:
Biochemistry and Biophysics Reports, Vol 16, Iss , Pp 145-151 (2018)
The compound MCI-154 was previously shown to increase the calcium sensitivity of cardiac muscle contraction. Using solution NMR spectroscopy, we demonstrate that MCI-154 interacts with the calcium-sensing subunit of the cardiac troponin complex, card
Externí odkaz:
https://doaj.org/article/7921eb263864415793b07715535b4a6d
Autor:
Sizhu Amelia Chen, Elena Arutyunova, Jimmy Lu, Muhammad Bashir Khan, Wioletta Rut, Mikolaj Zmudzinski, Shima Shahbaz, Jegan Iyyathurai, Eman W. Moussa, Zoe Turner, Bing Bai, Tess Lamer, James A. Nieman, John C. Vederas, Olivier Julien, Marcin Drag, Shokrollah Elahi, Howard S. Young, M. Joanne Lemieux
Publikováno v:
ACS Central Science. 9:696-708