Zobrazeno 1 - 3
of 3
pro vyhledávání: '"M James, Turner"'
Autor:
Lee D. Jennings, Derek C. Cole, Joseph R. Stock, Mohani N. Sukhdeo, John W. Ellingboe, Rebecca Cowling, Guixian Jin, Eric S. Manas, Kristi Y. Fan, Michael S. Malamas, Boyd L. Harrison, Steve Jacobsen, Rajiv Chopra, Peter A. Lohse, William J. Moore, Mary-Margaret O’Donnell, Yun Hu, Albert J. Robichaud, M. James Turner, Erik Wagner, Jonathan Bard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:767-771
Autor:
M. James Turner, Lee D. Jennings, Ann Aulabaugh, Derek Cecil Cole, E.S. Manas, Mohani N. Sukhdeo, Steve Jacobsen, Joseph Raymond Stock, Laura Lin, James Strand, Junjun Wu, Mark L. Stahl, John W. Ellingboe, Guixan Jin, and Ping Zhou, Kristi Fan, Boyd L. Harrison, Rajiv Chopra, Kristine Svenson, Frank E. Lovering, Yun Hu, Erik Wagner, Jeffrey Scott Condon, Rebecca Cowling, Michael S. Malamas, Jonathan A. Bard
Publikováno v:
Journal of Medicinal Chemistry. 49:6158-6161
BACE1 is an aspartyl protease responsible for cleaving amyloid precursor protein to liberate Abeta, which aggregates leading to plaque deposits implicated in Alzheimer's disease. We have identified small-molecule acylguanidine inhibitors of BACE1. Cr
Autor:
Lee D, Jennings, Derek C, Cole, Joseph R, Stock, Mohani N, Sukhdeo, John W, Ellingboe, Rebecca, Cowling, Guixian, Jin, Eric S, Manas, Kristi Y, Fan, Michael S, Malamas, Boyd L, Harrison, Steve, Jacobsen, Rajiv, Chopra, Peter A, Lohse, William J, Moore, Mary-Margaret, O'Donnell, Yun, Hu, Albert J, Robichaud, M James, Turner, Erik, Wagner, Jonathan, Bard
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(2)
The proteolytic enzyme beta-secretase (BACE-1) produces amyloid beta (Abeta) peptide, the primary constituent of neurofibrillary plaques, implicated in Alzheimer's disease, by cleavage of the amyloid precursor protein. A small molecule inhibitor of B