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Akademický článek

Tetraspanin immunoassay for the detection of extracellular vesicles and renal cell carcinoma

Autor: Misba Khan, Md. Khirul Islam, Mafiur Rahman, Bert Dhondt, Ileana Quintero, Maija Puhka, Panu M. Jaakkola, Urpo Lamminmäki, Janne Leivo

Publikováno v: Nano Select, Vol 5, Iss 9, Pp n/a-n/a (2024)

Abstract Half of patients with renal cell carcinoma (RCC) develop metastases. New and noninvasive biomarkers are needed for the diagnosis of RCC. The study aims to develop an EV‐based assay for the detection of RCC using a highly sensitive nanopart

Externí odkaz: https://doaj.org/article/e55164b7822c462caf1219c44a7c0720

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Akademický článek

A three-feature prediction model for metastasis-free survival after surgery of localized clear cell renal cell carcinoma

Autor: Kalle E. Mattila, Teemu D. Laajala, Sara V. Tornberg, Tuomas P. Kilpeläinen, Paula Vainio, Otto Ettala, Peter J. Boström, Harry Nisen, Laura L. Elo, Panu M. Jaakkola

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)

Abstract After surgery of localized renal cell carcinoma, over 20% of the patients will develop distant metastases. Our aim was to develop an easy-to-use prognostic model for predicting metastasis-free survival after radical or partial nephrectomy of

Externí odkaz: https://doaj.org/article/f097036ba65447a59e243f07da006031

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Akademický článek

Childhood exposure to parental smoking and life-course overweight and central obesity

Autor: Johanna M. Jaakkola, Suvi P. Rovio, Katja Pahkala, Jorma Viikari, Tapani Rönnemaa, Antti Jula, Harri Niinikoski, Juha Mykkänen, Markus Juonala, Nina Hutri-Kähönen, Mika Kähönen, Terho Lehtimäki, Olli T. Raitakari

Publikováno v: Annals of Medicine, Vol 53, Iss 1, Pp 208-216 (2021)

AbstractObjective To evaluate the association between childhood parental smoking exposure and the risk of overweight/obesity from childhood to adulthood.Methods This study leverages the data from two longitudinal population based cohort studies, the

Externí odkaz: https://doaj.org/article/f54f27e77acf43af9b68d72516d2b430

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Akademický článek

Transportable system enabling multiple irradiation studies under simultaneous hypoxia in vitro

Autor: Olli Metsälä, Joose Kreutzer, Heidi Högel, Petra Miikkulainen, Pasi Kallio, Panu M. Jaakkola

Publikováno v: Radiation Oncology, Vol 13, Iss 1, Pp 1-11 (2018)

Abstract Background Cells in solid tumours are variably hypoxic and hence resistant to radiotherapy - the essential role of oxygen in the efficiency of irradiation has been acknowledged for decades. However, the currently available methods for perfor

Externí odkaz: https://doaj.org/article/6ea51b107ef541d4b4b8b022d2044a8b

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Akademický článek

HIF prolyl hydroxylase PHD3 regulates translational machinery and glucose metabolism in clear cell renal cell carcinoma

Autor: Petra Miikkulainen, Heidi Högel, Krista Rantanen, Tomi Suomi, Petri Kouvonen, Laura L. Elo, Panu M. Jaakkola

Publikováno v: Cancer & Metabolism, Vol 5, Iss 1, Pp 1-17 (2017)

Abstract Background A key feature of clear cell renal cell carcinoma (ccRCC) is the inactivation of the von Hippel-Lindau tumour suppressor protein (pVHL) that leads to the activation of hypoxia-inducible factor (HIF) pathway also in well-oxygenated

Externí odkaz: https://doaj.org/article/653e76bfcb16431caf12436de93d5e7a

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