Výsledky vyhledávání - "M J. M. L. Gilmore"

Graft rejection following HLA matched T-lymphocyte depleted bone marrow transplantation

Publikováno v: British Journal of Haematology. 63:221-230

Bone marrow graft rejection following HLA-matched bone marrow transplantation (BMT) for leukaemia has been a rare problem. However, with the introduction of T-lymphocyte depleted BMT, graft rejection is recognized as a new complication. At the Royal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16271a5c4c3e2e95cb7424bcd46fbcf
https://doi.org/10.1111/j.1365-2141.1986.tb05544.x

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The Addition of Granulocyte-Macrophage Colony-Stimulating Factor to Normal Bone Marrow Enhances Cell Cycle and Clonogenicity Irrespective of Cryopreservation

Autor: J. Gmur, M J. M. L. Gilmore, H. G. Prentice, J. Burger

Publikováno v: Cytokines in Hemopoiesis, Oncology, and AIDS II ISBN: 9783540552420

Ex vivo treatment of bone marrow with haematopoietic growth factors may prove to be a useful method for priming haematopoietic cells prior to autologous and allogeneic transplantation. This approach may reduce the period of post-transplant aplasia [1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15c81851b08b0ef3ec04f0e8212dbc7f
https://doi.org/10.1007/978-3-642-48715-6_6

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Standardization of the Processing of Human Bone Marrow for Allogeneic Transplantation

Autor: M. J. M. L. Gilmore, H. G. Prentice

Publikováno v: Vox Sanguinis. 51:202-206

Allogeneic bone marrow transplantation has been undertaken within this centre on 62 patients with acute or chronic leukaemia. Employing the standard separation protocol described, all bone marrows were processed on the 2991 Blood Cell Processor to is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65645f33892bd2962fc469284807115d
https://doi.org/10.1159/000461492

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DEPLETION OF T LYMPHOCYTES IN DONOR MARROW PREVENTS SIGNIFICANT GRAFT-VERSUS-HOST DISEASE IN MATCHED ALLOGENEIC LEUKAEMIC MARROW TRANSPLANT RECIPIENTS

Autor: S. Graphakos, Hilary A. Blacklock, D. Skeggs, M. J. M. L. Gilmore, J. Patterson, H. G. Prentice, A. V. Hoffbrand, N. Tidman, L. Price-Jones, George Janossy, K. Ivory, S. Ball, L.K. Trejdosiewicz, D. D. Panjwani

Publikováno v: The Lancet. 323:472-476

For more than 15 years preclinical studies have suggested that acute graft-versus-host disease (aGvHD) might be prevented by the removal of immunocompetent T lymphocytes from the donor marrow inoculum. To test this observation in man 14 patients were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a3da767cf45f4fed069e06bbbefc27
https://doi.org/10.1016/s0140-6736(84)92848-4

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Standardization of T-cell depletion in HLA matched bone marrow transplantation

Autor: K. Ivory, S. Graphakos, M. J. M. L. Gilmore, A. V. Hoffbrand, H. G. Prentice, J. Patterson, Malcolm K. Brenner, George Janossy

Publikováno v: British Journal of Haematology. 64:69-75

Summary. The IBM 2991 Blood Cell Processor has been used to isolate a mononuclear cell (MNC) fraction from the marrow of 31 allogeneic donors. The MNC fraction was then incubated with a combination of two murine monoclonal antibodies MBG6 (CD6) and R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4eaef63aec9428d3fe14fc853c6adf4
https://doi.org/10.1111/j.1365-2141.1986.tb07574.x

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The role of monoclonal antibodies in the prevention of graft versus host disease

Autor: M. J. M. L. Gilmore, H. G. Prentice, H. A. Blacklock, George Janossy, A. V. Hoffbrand, K. Ivory

Publikováno v: Medical Oncology and Tumor Pharmacotherapy. 1:279-284

We have previously reported that the elimination of T-lymphocytes (greater than 99%) from the donor bone marrow prevents significant graft versus host disease (GvHD). This has been confirmed by other centres. Many of these groups have applied monoclo

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https://doi.org/10.1007/bf02934536

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ABO-INCOMPATIBLE BONE-MARROW TRANSPLANTATION: REMOVAL OF RED BLOOD CELLS FROM DONOR MARROW AVOIDING RECIPIENT ANTIBODY DEPLETION

Autor: M. J. M. L. Gilmore, C.B.T Knight, G. Hazlehurst, J.P.M Evans, David D.F. Ma, A. V. Hoffbrand, H. G. Prentice, Hilary A. Blacklock

Publikováno v: The Lancet. 320:1061-1064

Eight patients with acute leukaemia undergoing allogeneic bone-marrow transplantation from ABO-incompatible donors received red-cell-depleted donor marrow without any procedure to diminish their anti-ABO antibody titres. Successful marrow red-cell re

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https://doi.org/10.1016/s0140-6736(82)90003-4

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Allogeneic bone marrow transplantation: the monitoring of granulocyte macrophage colonies following the collection of bone marrow mononuclear cells and after the subsequent in-vitro cytolysis of OKT3 positive lymphocytes

Autor: George Janossy, S. Schey, H. G. Prentice, G. Goldstein, E. Price Jones, M. J. M. L. Gilmore, N Tidman, H. A. Blacklock, A. V. Hoffbrand

Publikováno v: British journal of haematology. 55(4)

Marrow nucleated cells from eight normal allogeneic donors was layered on Ficoll-Metrizoate to isolate the mononuclear cell fraction. The cells were then washed to remove Ficoll-Metrizoate and coagulation factors prior to resuspension in a balanced s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e6d59e2e80e22bb5df3a93953b5704
https://pubmed.ncbi.nlm.nih.gov/6422974

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Analysis of Rejection in HLA Matched T-Depleted Bone Marrow Transplants

Publikováno v: 11th Annual meeting of the EBMT ISBN: 9783662393994

In February 1984 a collaborative trial was begun using the Royal Free (RF) cocktail of MBG6 and RFT8 monoclonal antibodies to T-deplete donor marrow for allogeneic BMT for leukaemia. The trial followed the successful use of the cocktail in 25 patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c38af8f531887bf9b9c16f8fe77b0df
https://doi.org/10.1007/978-3-662-40457-7_93

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Bone Marrow Transplantation in First CR of Acute Leukaemia using T-Depleted Marrow from HLA Identical Sibling Donors

Autor: J. Z. Wimperis, George Janossy, J. K. Pattinson, A. Thomas, J.-P. Grob, N. Bell, John F. Hancock, H. G. Prentice, A. V. Hoffbrand, M. J. M. L. Gilmore, D. Skeggs, Malcolm K. Brenner, J. Patterson

Publikováno v: Minimal Residual Disease in Acute Leukemia 1986 ISBN: 9789401083980

Since May 1983 and following the institution of our present studies of “total” T-lymphocyte depletion for graft versus host disease (GvHD) prevention we have transplanted 22 patients in first complete remission (1st CR) of acute leukaemia using H

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https://doi.org/10.1007/978-94-009-4273-8_30

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