Zobrazeno 1 - 10
of 22
pro vyhledávání: '"M J Walport"'
Publikováno v:
The Journal of Immunology. 156:4429-4434
We investigated the mechanisms underlying the regulation of complement genes C3 and C4 by IFN-gamma. IFN-gamma (500 U/ml, 24 h incubation) increased steady state mRNA levels for both C3 and C4 in three different cell types (Hep G2, U937, and primary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ceb3f09bbb0a08aa2c085e246171aac
https://doi.org/10.4049/jimmunol.156.11.4429
https://doi.org/10.4049/jimmunol.156.11.4429
Publikováno v:
The Journal of Immunology. 156:3051-3056
The majority of complement protein C3 is synthesized by the liver, but many other cell types produce small amounts of functionally active C3. The overall contribution of such extrahepatic C3 production to the total circulating C3 level is unknown. Bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a91c58140101174bc62de4e11991b974
https://doi.org/10.4049/jimmunol.156.8.3051
https://doi.org/10.4049/jimmunol.156.8.3051
Autor:
K A Davies, P T Chapman, P J Norsworthy, F Jamar, P Athanassiou, E T Keelan, A A Harrison, R M Binns, D O Haskard, M J Walport
Publikováno v:
The Journal of Immunology. 155:5760-5768
Efficient delivery of immune complexes (ICs) to the mononuclear phagocytic system, and subsequent IC processing, may prevent their potentially harmful effects in other tissues and may also be important in the development of humoral immune responses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3356e91c51bc8bb2347f8fee1c22e23
https://doi.org/10.4049/jimmunol.155.12.5760
https://doi.org/10.4049/jimmunol.155.12.5760
Autor:
I Bartók, M J Walport
Publikováno v:
The Journal of Immunology. 154:5367-5375
The two common polymorphic variants of C3 are C3S/HAV4.1- and C3F/HAV4.1+. It was reported previously that erythrocytes coated with C3F rosetted more strongly with mononuclear cells than erythrocytes coated with C3S. We examined the binding of C3S/HA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21e6a574a8445b6be2c9b47586f73f35
https://doi.org/10.4049/jimmunol.154.10.5367
https://doi.org/10.4049/jimmunol.154.10.5367
Publikováno v:
The Journal of Immunology. 151:3866-3873
We have examined the effects of hereditary homozygous C2 deficiency on the processing of radiolabeled soluble immune complexes (IC). A patient with C2 deficiency was studied before and after treatment with fresh frozen plasma (FFP). Hepatitis B surfa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3519cb6879a471672ca62c72c66841e0
https://doi.org/10.4049/jimmunol.151.7.3866
https://doi.org/10.4049/jimmunol.151.7.3866
Publikováno v:
European journal of immunology. 31(7)
A critical role for complement in the regulation of self tolerance has been proposed to explain the strong association between complement deficiency and autoimmunity. To elucidate the role of the classical pathway of complement in the maintenance of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9ff93b39ea8beb35da613e9dad1a446b
https://pubmed.ncbi.nlm.nih.gov/11449362
https://pubmed.ncbi.nlm.nih.gov/11449362
Autor:
M G, Robson, M J, Walport
Publikováno v:
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 31(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4e29fedfebe7f2d50d492b4491f3c713
https://pubmed.ncbi.nlm.nih.gov/11422126
https://pubmed.ncbi.nlm.nih.gov/11422126
Autor:
M J, Walport
Publikováno v:
The New England journal of medicine. 344(14)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4908d31d59de8efdc3c09a89d0bc3824
https://pubmed.ncbi.nlm.nih.gov/11287977
https://pubmed.ncbi.nlm.nih.gov/11287977
Publikováno v:
Deutsche Gesellschaft für Chirurgie ISBN: 9783540417187
Introduction: To investigate the pathophysiology of postoperative peritonitis and sepsis before conducting a costly clinical trial, experiments in knock-out (KO) animal models were performed (frequently in mice). The currently available sepsis models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25c570db2712e53b119d87a4c6cd15d3
https://doi.org/10.1007/978-3-642-56698-1_96
https://doi.org/10.1007/978-3-642-56698-1_96
Publikováno v:
Advances in immunology. 76
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::38dba53365231bc68af94b8b1e8ba4d6
https://pubmed.ncbi.nlm.nih.gov/11079100
https://pubmed.ncbi.nlm.nih.gov/11079100