Zobrazeno 1 - 10 of 16 pro vyhledávání: '"M J P, Welters"'
1
Akademický článek
Tbet-positive regulatory T cells accumulate in oropharyngeal cancers with ongoing tumor-specific type 1 T cell responses
Autor: S. J. Santegoets, C. L. Duurland, E. S. Jordanova, J. J. van Ham, I. Ehsan, S. L. van Egmond, M. J. P. Welters, S. H. van der Burg
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-12 (2019)
Abstract Regulatory T cells (Tregs) may comprise different subsets allowing them to efficiently suppress different types of effector T cells. In this study, we show that high numbers of both conventional and Tbet co-expressing Foxp3hi Tregs accumulat
Externí odkaz: https://doaj.org/article/62868b7ab4e84d2c8edcadb20c09e374
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2
Akademický článek
The blood mMDSC to DC ratio is a sensitive and easy to assess independent predictive factor for epithelial ovarian cancer survival
Autor: S. J. A. M. Santegoets, A. F. de Groot, E. M. Dijkgraaf, A. M. Carnaz Simões, V. E. van der Noord, J. J. van Ham, M. J. P. Welters, J. R. Kroep, S. H. van der Burg
Publikováno v: OncoImmunology, Vol 7, Iss 8 (2018)
Epithelial ovarian cancer (EOC) may cause abnormal blood levels of leukocytes. This paraneoplastic manifestation is associated with a worse response to therapy and shorter survival. To understand the complexity and nature of these leukocytes, we diss
Externí odkaz: https://doaj.org/article/f4b6784697f04c0297d742904ad36aca
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3
Akademický článek
Impact of (chemo)radiotherapy on immune cell composition and function in cervical cancer patients
Autor: H. van Meir, R. A. Nout, M. J. P. Welters, N. M. Loof, M. L. de Kam, J. J. van Ham, S. Samuels, G. G. Kenter, A. F. Cohen, C. J. M. Melief, J. Burggraaf, M. I. E. van Poelgeest, S. H. van der Burg
Publikováno v: OncoImmunology, Vol 6, Iss 2 (2017)
New treatments based on combinations of standard therapeutic modalities and immunotherapy are of potential use, but require a profound understanding of immune modulatory properties of standard therapies. Here, the impact of standard (chemo)radiothera
Externí odkaz: https://doaj.org/article/9ab1477d33ed4379aebc6f6b01ce1a4c
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4
The identification of patients at high risk for recurrent disease after treatment for early-stage cervical cancer
Autor: H, Van Meir, I J, du Burck, M L, de Kam, M J P, Welters, S H, van der Burg, J B M Z, Trimbos, C D, de Kroon, M I E, van Poelgeest
Publikováno v: European journal of gynaecological oncology. 38(1)
To investigate prognostic factors in patients with recurrent cervical cancer after treatment of early-stage disease in order to identify high-risk patients who might benefit from alternative treatment strategies.The authors retrospectively analyzed c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::004ac7d856ccdf21ef585afc968e052b
https://pubmed.ncbi.nlm.nih.gov/29767860
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5
Increased numbers of circulating donor-specific T helper lymphocytes after human heart valve transplantation
Autor: L. M. B. Vaessen, W. Weimar, Alexander P.A. Stegmann, F. B. S. Oei, M. J. P. Welters, Ad J.J.C. Bogers
Publikováno v: Clinical & Experimental Immunology, 124, 353-358. Wiley-Blackwell Publishing Ltd
SUMMARY Implantation of cryopreserved human donor heart valves for either congenital or acquired cardiac disease has been performed since the last three decades. Although the clinical outcome is good, long-term valve degeneration resulting in dysfunc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6083acb3f45fdfc0843277d20f7f67
https://pure.eur.nl/en/publications/c870520c-6a62-405d-b1f0-68c5d4b88958
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6
Role of glutathione, glutathione S-transferases and multidrug resistance-related proteins in cisplatin sensitivity of head and neck cancer cell lines
Autor: R.J. Scheper, R.A. Baan, M.J. Flens, A.M.J. Fichtinger-Schepman, Boudewijn J.M. Braakhuis, M. J. P. Welters
Publikováno v: British Journal of Cancer
British Journal of Cancer, 4, 77, 556-561
Resistance to chemotherapy is a major problem in the treatment of patients with head and neck squamous cell carcinoma (HNSCC). Important factors involved are drug detoxification by glutathione (GSH) and reduced drug accumulation due to active transpo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde0c074fd69c1e8328422b5c1645c2f
http://europepmc.org/articles/PMC2149938
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7
The potential of platinum-DNA adduct determination in ex vivo treated tumor fragments for the prediction of sensitivity to cisplatin chemotherapy
Autor: Boudewijn J.M. Braakhuis, A. J. Jacobs-Bergmans, W.J.F. van der Vijgh, Robert A. Baan, A.M.J. Fichtinger-Schepman, M. J. P. Welters, A Kegel
Publikováno v: Annals of Oncology, 10, 97-103. Oxford University Press
Annals of Oncology, 1, 10, 97-103
Welters, M J P, Braakhuis, B J M, Jacobs-Bergmans, A J, Kegel, A, Baan, R A, van der Vijgh, W J F & Fichtinger-Schepman, A M J 1999, ' The potential of platinum-DNA adduct determination in ex vivo treated tumor fragments for the prediction of sensitivity to cisplatin chemotherapy ', Annals of Oncology, vol. 10, pp. 97-103 . https://doi.org/10.1023/A:1008324803494
Annals of Oncology, 10, 97-103
Background: Response to cisplatin-therapy is assumed to be related to the formation of platinum (Pt)-DNA adducts. Measurement of these adducts prior to therapy could be of value to improve cisplatin based cancer therapy. Materials and methods: We det
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54cbd00414ce78c512a069002ac1173c
https://research.vumc.nl/en/publications/8afaa686-92a2-49b4-83e0-022a5e4a2e57
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8
Pharmacodynamics of cisplatin in human head and neck cancer: correlation between platinum content, DNA adduct levels and drug sensitivity in vitro and in vivo
Autor: A.M.J. Fichtinger-Schepman, Boudewijn J.M. Braakhuis, A Kegel, M. J. P. Welters, A. J. Jacobs-Bergmans, W.J.F. van der Vijgh, Robert A. Baan
Publikováno v: Welters, M J P, Fichtinger-Schepman, A M J, Baan, R A, Jacobs-Bergmans, A J, Kegel, A, van der Vijgh, W J F & Braakhuis, B J M 1999, ' Pharmacodynamics of cisplatin in human head and neck cancer: correlation between platinum content, DNA adduct levels and drug sensitivity in vitro and in vivo ', British Journal of Cancer, vol. 79, pp. 82-88 . https://doi.org/10.1038/sj.bjc.6690015
British Journal of Cancer, 79, 82-88. Nature Publishing Group
British Journal of Cancer, 1, 79, 82-88
British Journal of Cancer
Total platinum contents and cisplatin–DNA adduct levels were determined in vivo in xenografted tumour tissues in mice and in vitro in cultured tumour cells of head and neck squamous cell carcinoma (HNSCC), and correlated with sensitivity to cisplat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f87e8ea895dd180ee4a995deac35c70
https://research.vumc.nl/en/publications/4d75c7cc-1ec2-4647-983c-7b2b1ef896bb
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9
Improved 32P-postlabelling assay for the quantification of the major platinum-DNA adducts
Autor: Boudewijn J.M. Braakhuis, M. J. P. Welters, Robert A. Baan, A. J. Jacobs-Bergmans, A.M.J. Fichtinger-Schepman, J. Ma, M. Maliepaard, Jan H.M. Schellens, W. J. F. Van Der Vijgh
Publikováno v: Welters, M J P, Maliepaard, M, Jacobs-Bergmans, A J, Baan, R A, Schellens, J H M, Ma, J G, van der Vijgh, W J F & Braakhuis, B J M 1997, ' Improved P-32 postlabelling assay for teh quantification of the major platinum-DNA adducts ', Carcinogenesis, vol. 18, pp. 1767-1774 . https://doi.org/10.1093/carcin/18.9.1767
Carcinogenesis, 18, 1767-1774. Oxford University Press
For the improvement of chemotherapy with platinum (Pt)-containing drugs a sensitive assay to detect the induced Pt-DNA adducts is needed. Therefore, the 32P-postlabelling assay, described by Blommaert and Saris (Nucleic Acids Res., 1995, 23, 1300-130
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b0af98a04c876d9bcb8d177de6165f
https://pubmed.ncbi.nlm.nih.gov/9328174
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10
Relationship between the parameters cellular differentiation, doubling time and platinum accumulation and cisplatin sensitivity in a panel of head and neck cancer cell lines
Autor: Robert A. Baan, Mario A. J. A. Hermsen, Jacqueline Cloos, M. J. P. Welters, Wim J.F. van der Vijgh, A.M.J. Fichtinger-Schepman, Boudewijn J.M. Braakhuis
Publikováno v: International Journal of Cancer, 71(3), 410-415. Wiley-Liss Inc.
Welters, M J P, Fichtinger-Schepman, A M J, Baan, R A, Hermsen, M A J A, Van Der Vijgh, W J F, Cloos, J & Braakhuis, B J M 1997, ' Relationship between the parameters cellular differentiation, doubling time and platinum accumulation and cisplatin sensitivity in a panel of head and neck cancer cell lines ', International Journal of Cancer, vol. 71, no. 3, pp. 410-415 . https://doi.org/10.1002/(SICI)1097-0215(19970502)71:3<410::AID-IJC18>3.0.CO;2-J
Patients with head and neck squamous cell carcinoma (HNSCC) treated with cisplatin show a large inter-individual variation in tumor response. Little is known about factors that contribute to this variation. The aim of our study was to correlate the s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::451133cb90416ced8343243c27f3aca7
https://research.vumc.nl/en/publications/7a2efd1c-a327-492c-ae79-065b6e1c1281
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