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Intravenous synthetic peptide MBP8298 delayed disease progression in an HLA Class II-defined cohort of patients with progressive multiple sclerosis: results of a 24-month double-blind placebo-controlled clinical trial and 5 years of follow-up treatment

Autor: Kenneth G. Warren, M. J. Krantz, L. Z. Ferenczi, Ingrid Catz

Publikováno v: European Journal of Neurology. 13:887-895

MBP8298 is a synthetic peptide with a sequence corresponding to amino acid residues 82-98 of human myelin basic protein (DENPVVHFFKNIVTPRT). It represents the immunodominant target for both B cells and T cells in multiple sclerosis (MS) patients with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb05e5f192b636320f91a37a5d6e83d
https://doi.org/10.1111/j.1468-1331.2006.01533.x

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Liposomal Formulations of Synthetic MUC1 Peptides: Effects of Encapsulation versus Surface Display of Peptides on Immune Responses

Autor: M J Krantz, Wladyslaw Budzynski, B. M. Longenecker, J. A. Rogers, R. Rao Koganty, H. H. Guan, Mark A. Reddish, John Samuel

Publikováno v: Bioconjugate Chemistry. 9:451-458

Synthetic human MUC1 peptides are important candidates for therapeutic cancer vaccines. To explore whether a human MUC1 peptide BP25 (STAPPAHGVTSAPDTRPAPGSTAPP) can be rendered immunogenic by incorporation in liposomes, the effects of physical associ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d9ff7cc7c7c2b280d81e96520c4fb3
https://doi.org/10.1021/bc970183n

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Immunogenicity and antitumor activity of a liposomal MUC1 peptide-based vaccine

Autor: John Samuel, R. Rao Koganty, Wladyslaw Budzynski, B. M. Longenecker, G L Zimmermann, Mark A. Reddish, M J Krantz, Lei Ding

Publikováno v: International Journal of Cancer. 75:295-302

A human MUC1-transfected mouse mammary adenocarcinoma cell line (GZHI) was used to develop both subcutaneous and intravenous tumor models. A vaccine formulation comprised of a 24 mer (human MUC1) synthetic peptide encapsulated with monophosphoryl lip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d8fd84d333d536554ae444b774704ba
https://doi.org/10.1002/(sici)1097-0215(19980119)75:2<295::aid-ijc20>3.0.co

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Rapid induction of primary human CD4+ and CD8+ T cell responses against cancer-associated MUC1 peptide epitopes

Autor: Mark A. Reddish, Babita Agrawal, M J Krantz, B. M. Longenecker

Publikováno v: International immunology. 10(12)

Antigen-specific MHC class II- and class I-restricted helper and cytotoxic T cell responses are important anti-cancer immune responses. MUC1 mucin is a potentially important target for immunotherapy because of its high expression on most human adenoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2c2448c0a72c7c1b8ebde99a861b24
https://pubmed.ncbi.nlm.nih.gov/9885912

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MUC1 synthetic peptide inhibition of intercellular adhesion molecule-1 and MUC1 binding requires six tandem repeats

Autor: J L, Kam, L H, Regimbald, J H, Hilgers, P, Hoffman, M J, Krantz, B M, Longenecker, J C, Hugh

Publikováno v: Cancer research. 58(23)

We reported recently that breast cancer-associated MUC1 is a ligand for intercellular adhesion molecule-1 (ICAM-1; L. H. Regimbald et al., Cancer Res., 56: 4244-4249, 1996). We report here the results of a competitive indirect binding assay to detect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::96d37966adcfb6439d5bb45c58cacd65
https://pubmed.ncbi.nlm.nih.gov/9850097

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Expression of MUC1 mucin on activated human T cells: implications for a role of MUC1 in normal immune regulation

Autor: B, Agrawal, M J, Krantz, J, Parker, B M, Longenecker

Publikováno v: Cancer research. 58(18)

MUC1 mucin is expressed by normal and malignant epithelial cells and is thought to function through cell-cell interactions and transmembrane signal transduction events. Secreted cancer-associated MUC1 is immunosuppressive and inhibits human T-cell pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::878624d474abfbd8efa6f2dfa54bcf6f
https://pubmed.ncbi.nlm.nih.gov/9751614

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Immunogenicity and antitumor activity of a liposomal MUC1 peptide-based vaccine

Autor: J, Samuel, W A, Budzynski, M A, Reddish, L, Ding, G L, Zimmermann, M J, Krantz, R R, Koganty, B M, Longenecker

Publikováno v: International journal of cancer. 75(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fe9ed433366bee70cb97f79ce3a351ea
https://pubmed.ncbi.nlm.nih.gov/9462722

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Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2

Autor: Mark A. Reddish, Babita Agrawal, M J Krantz, B. M. Longenecker

Publikováno v: Nature medicine. 4(1)

A number of adenocarcinomas abundantly express and secrete underglycosylated MUC1 mucin. Underglycosylation exposes tandem repeat peptide sequences on cancer-associated MUC1 mucin that are normally cryptic. High levels of MUC1 mucin are correlated wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702f1d4ac1c53d9c9928ac67223ecd9e
https://pubmed.ncbi.nlm.nih.gov/9771724

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Does pregnancy immunize against breast cancer?

Autor: B, Agrawal, M A, Reddish, M J, Krantz, B M, Longenecker

Publikováno v: Cancer research. 55(11)

Multiparity has been linked with protection against breast cancer. T cells from biparous women, but not T cells from nulliparous women or men, specifically proliferated in response to core peptide sequences of a human breast cancer-associated mucin (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::49bd70ff6ca8257cf6d22ab479167ee9
https://pubmed.ncbi.nlm.nih.gov/7538899

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