Zobrazeno 1 - 10
of 21
pro vyhledávání: '"M J Janusz"'
Autor:
Steven D. Shapiro, Walker T. McGraw, J. Travis, M. J. Janusz, M. Hare, S. L. Durham, Jan Potempa, Robert N. Pike
Publikováno v:
Inflammation Research. 48:280-288
Objective and Design: Identify and characterize the matrix metalloproteinase responsible for cartilage proteoglycan degradation mediated by a macrophage cell line in a cell culture model that resembles some aspects of rheumatoid pannus.¶Materials or
Autor:
Herman Schreuder, William A. Metz, R.V. Hoffman, Robert J. Cregge, Farr Robert A, Koehl Jack Roger, Hwa-Ok Kim, Norton P. Peet, Shyam Sunder, S L Durham, M J Janusz, C M Hare, Chantal Tardif, J.T. Pelton, Shujaath Mehdi, S.L. Gallion
Publikováno v:
Journal of Medicinal Chemistry. 41:2461-2480
A series of P2-modified, orally active peptidic inhibitors of human neutrophil elastase (HNE) are reported. These pentafluoroethyl ketone-based inhibitors were designed using pentafluoroethyl ketone 1 as a model. Rational structural modifications wer
Autor:
Michael R. Angelastro, Joseph P. Burkhart, M J Janusz, Chen Tm, Edward W. Huber, Koehl, Baugh Le, S L Durham, Philippe Bey, C M Hare
Publikováno v:
Journal of Medicinal Chemistry. 37:4538-4553
Valylprolylvalyl pentafluoroethyl ketones with different N-protecting groups were evaluated in vitro and in vivo as inhibitors of human neutrophil elastase (HNE). Several of these compounds were found to be orally active in HNE-induced rat and hamste
Autor:
M J Janusz, M Hare
Publikováno v:
The Journal of Immunology. 150:1922-1931
A number of human and mouse macrophage and fibroblast cell lines were examined for their ability to degrade cartilage proteoglycan in an attempt to establish a cell culture model of cartilage degradation. The mouse transformed macrophage cell line J7
Autor:
M J Janusz, N S Doherty
Publikováno v:
The Journal of Immunology. 146:3922-3928
The granule proteases of human neutrophils are thought to be responsible for the connective tissue destruction associated with certain inflammatory diseases. Using a model system for the degradation of a macromolecular connective tissue substrate, pu
Autor:
S. L. Durham, M. J. Janusz
Publikováno v:
Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 46(12)
Objective and Design: The neutrophil elastase inhibitor MDL 101,146 was examined for its anti-arthritic effect and to determine the role of neutrophil elastase in collagen-induced arthritis and adjuvant arthritis.¶Material: The collagen-induced arth
Publikováno v:
Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 46
Autor:
M J, Janusz, S L, Durham, C M, Hare, J L, Geary, A K, Mandagere, J C, Poole, T N, Thompson, D, Xu, M R, Anagelastro, J P, Burkhart
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 275(3)
Human neutrophil elastase (HNE) is a serine proteinase capable of degrading a number of connective tissue macromolecules and has been implicated in the destructive processes associated with several chronic inflammatory diseases. A large series of pep
Autor:
Sunder S, Koehl, Joseph P. Burkhart, M J Janusz, Edward W. Huber, S L Durham, Shujaath Mehdi, William A. Metz, Michael R. Angelastro, Shum Pw
Publikováno v:
Journal of medicinal chemistry. 38(2)
Several analogs of N-[4-(4-morpholinylcarbonyl)benzoyl]-L-valyl-N-[3,3,4,4,4-penta fluoro-1- (1-methylethyl)-2-oxobutyl]-L-prolinamide (1), in which the chiral center of the P1 residue has been eliminated, were synthesized and tested as inhibitors of
Autor:
S L, Durham, C M, Hare, M R, Angelastro, J P, Burkhart, J R, Koehl, A L, Marquart, S, Mehdi, N P, Peet, M J, Janusz
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 270(1)
Human neutrophil elastase (HNE) is a serine proteinase capable of degrading a number of connective tissue macromolecules and has been implicated in the destructive processes associated with a number of chronic inflammatory diseases. N-[4-(4-morpholin