Zobrazeno 1 - 10
of 42
pro vyhledávání: '"M J Holness"'
Publikováno v:
Current Molecular Pharmacology. 5:224-240
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12a521420681351f90545eeaa7c56df0
https://doi.org/10.2174/1874467211205020224
https://doi.org/10.2174/1874467211205020224
Publikováno v:
Clinical Science. 112:93-111
The prevalence of obesity has been increasing at a rapid rate over the last few decades. Although the primary defect can be attributed to an imbalance of energy intake over energy expenditure, the regulation of energy balance is now recognized to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a91add67890845684de12f57402225f
https://doi.org/10.1042/cs20060150
https://doi.org/10.1042/cs20060150
Publikováno v:
Diabetes. 53:S166-S171
In rats fed a high-saturated fat diet, replacement of a small percentage of total fatty acids with long-chain ω-3 fatty acids from fish oil for the duration of high-fat feeding prevents the development of insulin resistance. We investigated the effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5389fcee375458f2defea668e757d80
https://doi.org/10.2337/diabetes.53.2007.s166
https://doi.org/10.2337/diabetes.53.2007.s166
Publikováno v:
Biochemical Journal. 352:731-738
Activation of the pyruvate dehydrogenase (PDH) complex (PDHC) promotes glucose disposal, whereas inactivation conserves glucose. The PDH kinases (PDHKs) regulate glucose oxidation through inhibitory phosphorylation of PDHC. The adult rat heart contai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::952969335ac7c27aa14b286e92824322
https://doi.org/10.1042/bj3520731
https://doi.org/10.1042/bj3520731
Publikováno v:
European Journal of Biochemistry. 229:741-748
The provision of a diet high in saturated and monounsaturated fat for 28 days evoked a significant (1.9-fold) increase in pyruvate-dehydrogenase kinase activity measured in isolated mitochondria from representative slow-twitch (oxidative) skeletal mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96caab538aab08c725dc86c016658f71
https://doi.org/10.1111/j.1432-1033.1995.tb20522.x
https://doi.org/10.1111/j.1432-1033.1995.tb20522.x
Publikováno v:
Current molecular pharmacology. 5(2)
Chronically-elevated plasma lipid concentrations, particularly when combined with high glucose, elicit a plethora of effects that cause the progressive deterioration of insulin sensitivity and ultimately cellular malfunction or death. This review add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1763a4303049940f79148dc27079d684
https://pubmed.ncbi.nlm.nih.gov/22122452
https://pubmed.ncbi.nlm.nih.gov/22122452
Autor:
Mary C. Sugden, M. J. Holness
Publikováno v:
Journal of Endocrinology. 127:187-190
Introduction Theories for the mechanisms underlying the development of insulin resistance have included defects in insulin binding, inhibition of insulin receptor tyrosine kinase, and impaired translocation of glucose across the plasma membrane. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63757b753af6875e089272e592eb5939
https://doi.org/10.1677/joe.0.1270187
https://doi.org/10.1677/joe.0.1270187
Autor:
M J Holness, M C Sugden
Publikováno v:
Biochemical Journal. 268:77-81
The percentages of pyruvate dehydrogenase complex (PDH) in the active form (PDHa) in two lipogenic tissues (liver and brown adipose tissue) in the fed state were 12.0% and 13.4% respectively. After acute (0.5 h) insulin treatment, PDHa activities had
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d2ad3e0db0e647ac884e16c0a26300
https://doi.org/10.1042/bj2680077
https://doi.org/10.1042/bj2680077
Autor:
M J Holness, M C Sugden
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 284(5)
The mitochondrial pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate, linking glycolysis to the tricarboxylic acid cycle and fatty acid (FA) synthesis. Knowledge of the mechanisms that regulate PDC activity is im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e45355e94ea2c112ad0c8518251233
https://pubmed.ncbi.nlm.nih.gov/12676647
https://pubmed.ncbi.nlm.nih.gov/12676647
Autor:
M C, Sugden, M J, Holness
Publikováno v:
Current drug targets. Immune, endocrine and metabolic disorders. 2(2)
The mitochondrial pyruvate dehydrogenase complex (PDC) catalyses the oxidative decarboxylation of pyruvate, and links glycolysis to the tricarboxylic acid cycle and ATP production. Adequate flux through PDC is important in tissues with a high ATP req
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd8512054616b0e964a31f9c83c2a380
https://pubmed.ncbi.nlm.nih.gov/12476789
https://pubmed.ncbi.nlm.nih.gov/12476789