Zobrazeno 1 - 10
of 16
pro vyhledávání: '"M J Hauer"'
Publikováno v:
Xenobiotica. 27:1039-1051
1. Metabolites of the cyclic bisphosphonate ester, 4-[2,2'-bis-(5,5- dimethyl-1,3,2-dioxaphosphorinan-2-yl)] butanoyl-3-fluoro-benzene (PNU-91638) in bile or urine of the male Sprague-Dawley rat were characterized by mass spectrometry. The chronicall
Autor:
Schwartz Tm, G L Bundy, K A Koeplinger, J. K. Mayo, G. E. Padbury, Zhiyang Zhao, Harbach Pr, Zimmermann Dc, C.S. Aaron, M J Hauer, L S Banitt
Publikováno v:
Chemical Research in Toxicology. 9:1230-1239
U-89843 is a novel pyrrolo[2,3-d]pyrimidine antioxidant with prophylactic activity in animal models of lung inflammation. During preclinical safety evaluation, U-89843 was found to give a positive response in the in vitro unscheduled DNA synthesis (U
Autor:
J G, Slatter, D J, Stalker, K L, Feenstra, I R, Welshman, J B, Bruss, J P, Sams, M G, Johnson, P E, Sanders, M J, Hauer, P E, Fagerness, R P, Stryd, G W, Peng, E M, Shobe
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(8)
Linezolid (Zyvox), the first of a new class of antibiotics, the oxazolidinones, is approved for treatment of Gram-positive bacterial infections, including resistant strains. The disposition of linezolid in human volunteers was determined, after a 500
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(7)
Dapsone activates CYP2C9-mediated metabolism in various expression systems and is itself metabolized by CYP2C9 to its hydroxylamine metabolite. Studies were conducted with expressed CYP2C9 to characterize the kinetic effects of dapsone (0-100 microM)
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(1)
Delavirdine, a non-nucleoside inhibitor of HIV-1 reverse transcriptase, is metabolized primarily through desalkylation catalyzed by CYP3A4 and CYP2D6 and by pyridine hydroxylation catalyzed by CYP3A4. It is also an irreversible inhibitor of CYP3A4. T
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(9)
In vitro studies were conducted to identify the hepatic enzyme(s) responsible for the oxidative metabolism of linezolid. In human liver microsomes, linezolid was oxidized to a single metabolite, hydroxylinezolid (M1). Formation of M1 was determined t
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(11)
In vitro studies were conducted to identify the hepatic cytochrome P-450 (CYP) enzymes responsible for the oxidative metabolism of the individual enantiomers of reboxetine. In human liver microsomes, each reboxetine enantiomer was metabolized to one
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 287(2)
Tirilazad mesylate (FREEDOX), a potent inhibitor of membrane lipid peroxidation in vitro, is under clinical development for the treatment of subarachnoid hemorrhage. In humans, tirilazad is cleared almost exclusively via hepatic elimination with a me
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 26(10)
Bropirimine (2-amino-5-bromo-6-phenyl-4-pyrimidinone) is a member of a class of antineoplastic agents known as aryl pyrimidinones. In human liver microsomal incubations, bropirimine oxidative metabolism is characterized by the formation of three meta
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 26(7)
The metabolism of delavirdine was examined using liver microsomes from several species with the aim of comparing metabolite formation among species and characterizing the enzymes responsible for delavirdine metabolism. Incubation of 10 microM [14C]de