Zobrazeno 1 - 5
of 5
pro vyhledávání: '"M J H, van Vugt"'
Autor:
J, Dulos, F P G, Wijnands, J A J, van den Hurk-van Alebeek, M J H, van Vugt, J A C, Rullmann, J-J G, Schot, M W G D M, de Groot, J L, Wagenaars, R, van Ravestein-van Os, R L, Smets, P M, Vink, C L, Hofstra, R L H, Nelissen, H, van Eenennaam
Publikováno v:
Clinical and experimental rheumatology. 31(4)
For many years the p38 MAP kinase (MAPK) has been a major anti-inflammatory target for the development of an oral therapy for rheumatoid arthritis (RA). However, disappointing results from Phase II clinical studies suggest that adaptations may occur,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5f92a6fea16aca2634734f2c4d693359
https://pubmed.ncbi.nlm.nih.gov/23558031
https://pubmed.ncbi.nlm.nih.gov/23558031
Publikováno v:
British Journal of Cancer
The combination of heat and chemotherapy was studied in an intraperitoneal tumour model. Rats bearing peritoneal CC531 tumours (2-6 mm) were treated i.p. with cDDP or CBDCA [maximal tolerated dose (MTD)] in combination with regional hyperthermia (41.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca9135cdd2bf5d0878ea445d180ef77
https://doi.org/10.1038/bjc.1994.45
https://doi.org/10.1038/bjc.1994.45
Publikováno v:
Biochemical pharmacology. 46(7)
Increased levels of cisplatin (cDDP)- and carboplatin (CBDCA)-DNA adducts were detected in cDDP (10 microM)- and CBDCA (6 mM)-treated CC531 cells when the temperature was raised from 37 degrees to 43 degrees. In the case of cDDP, increased DNA adduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88bd0624ff5aa0c30490a65495bb7e2c
https://pubmed.ncbi.nlm.nih.gov/8216374
https://pubmed.ncbi.nlm.nih.gov/8216374
Publikováno v:
Cancer Chemotherapy and Pharmacology, 32, 425-433. Springer Verlag
Los, G, Tuyt, L, van Vugt, M, Schornagel, J & Pinedo, H M 1993, ' Combination treatment of cis-and carboplatin in cancers restricted to the peritoneal cavity in the rat ', Cancer Chemotherapy and Pharmacology, vol. 32, pp. 425-433 .
Los, G, Tuyt, L, van Vugt, M, Schornagel, J & Pinedo, H M 1993, ' Combination treatment of cis-and carboplatin in cancers restricted to the peritoneal cavity in the rat ', Cancer Chemotherapy and Pharmacology, vol. 32, pp. 425-433 .
In the present study, cisplatin (cDDP) and carboplatin (CBDCA) were combined in different in vitro and in vivo assays to determine whether combined cDDP and CBDCA treatment would eventually lead to a better antitumor response. Co-incubation of CC531
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1101f352b5966403cc2e03df8e10d4
https://pubmed.ncbi.nlm.nih.gov/8258189
https://pubmed.ncbi.nlm.nih.gov/8258189
Autor:
Gerrit Los, Jaap Haveman, M. J. H. Van Vugt, J.J.G.W. Hendriks, Peter Sminia, D. González González
Publikováno v:
Sminia, P, Los, G, Hendriks, J J, van Vugt, M J, Haveman, J & González González, D 1992, ' The influence of hyperthermia on the uptake of cisplatin in the rat cervical spinal cord ', European Journal of Cancer, vol. 28A, no. 6-7, pp. 1139-43 .
European Journal of Cancer, 28A(6-7), 1139-43. Pergamon
European Journal of Cancer, 28A(6-7), 1139-43. Pergamon
The influence of local hyperthermia on the uptake of cisplatin in the rat cervical spinal cord was investigated. After single intraperitoneal or intravenous injection of cisplatin (5 mg/kg body weight), the spinal cord region cervical 5-thoracic 2 wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce0c2b42e1642a767e00209fbd0b747
https://pubmed.ncbi.nlm.nih.gov/1627385
https://pubmed.ncbi.nlm.nih.gov/1627385