Zobrazeno 1 - 10
of 53
pro vyhledávání: '"M J Gait"'
Publikováno v:
Nucleic Acids in Chemistry and Biology ISBN: 9781788019040
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fa3c157528f7d2dd41d2b85754b8cef
https://doi.org/10.1039/9781837671328-00627
https://doi.org/10.1039/9781837671328-00627
Publikováno v:
Methods in Molecular Biology ISBN: 9781493996698
Antisense oligonucleotides (ASOs) are a widely used form of gene therapy, which is translatable to multiple disorders. A major obstacle for ASO efficacy is its bioavailability for in vivo and in vitro studies. To overcome this challenge we use cell-p
Autor:
Raquel Manzano, A. Blain, M J Gait, Matthew J.A. Wood, Caroline Godfrey, Liz O'Donovan, Volker Straub, Corinne A. Betts, Guy A. MacGowan, Thibault Coursindel, E. Greally, Graham McClorey
Publikováno v:
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
PLoS ONE
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
PLoS ONE, Vol 13, Iss 6, p e0198897 (2018)
Universidad de Zaragoza
PLoS ONE
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
PLoS ONE, Vol 13, Iss 6, p e0198897 (2018)
Cardiac failure is a major cause of mortality in patients with Duchenne muscular dystrophy (DMD). Antisense-mediated exon skipping has the ability to correct out-of-frame mutations in DMD to produce truncated but functional dystrophin. Traditional an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0064f88864f9bd6698fc46ff73137357
https://ora.ox.ac.uk/objects/uuid:82754937-7621-4b3b-ac0f-6698b4717eab
https://ora.ox.ac.uk/objects/uuid:82754937-7621-4b3b-ac0f-6698b4717eab
Autor:
Miguel A. Varela, A Arzumanov, A F Klein, A Holland, Denis Furling, G Hazell, Richard Raz, M J Gait, Matthew J.A. Wood
Publikováno v:
Neuromuscular Disorders. 28:S8-S9
Antisense oligonucleotide (AON)-induced exon skipping is one of the most promising strategies for treating Duchenne muscular dystrophy (DMD) and other rare monogenic conditions. Phosphorodiamidate morpholino oligonucleotides (PMOs) and 2'-O-methyl ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee5db808d1ff0caf7f474e861d2f0c6c
https://europepmc.org/articles/PMC4576940/
https://europepmc.org/articles/PMC4576940/
Autor:
M J Gait, Miguel A. Varela, S. Ait benichou, Matthew J.A. Wood, Jack Puymirat, C. Bennett, D. Jauvin, A. Arzoumanov
Publikováno v:
Neuromuscular Disorders. 27:S212
Autor:
S Muses, E O'Donovan, Matthew J.A. Wood, Caroline Godfrey, R L Terry, M J Gait, John C. W. Hildyard, Graham McClorey, K E Wells, S El Andaloussi, Ornella Cappellari, Suzan M. Hammond, Dominic J. Wells, Corinne A. Betts, Thibault Coursindel
Publikováno v:
Neuromuscular Disorders. 25:S312-S313
We examined the effects on muscle physiology of restoring different levels of dystrophin in mdx mice with established dystrophic pathophysiology (12 weeks and older). Dystrophin expression was induced very efficiently using cell penetrating peptides
Publikováno v:
ChemInform. 23
Conjugates of oligonucleotides and analogues with cell penetrating peptides as gene silencing agents
Publikováno v:
Current pharmaceutical design. 11(28)
The review describes key aspects of the synthesis and biological activities of conjugates of oligonucleotides and their analogues with synthetic peptides, in particular aimed towards gene silencing applications. The common methods of synthesis of oli
Publikováno v:
Bioorganicheskaia khimiia. 29(3)
Conjugates of amines or short peptides with oligonucleotides containing 5'-terminal carboxyl group were prepared by solid phase chemical synthesis. A correlation between the physicochemical parameters and retention times of the synthesized conjugates