Zobrazeno 1 - 10
of 27
pro vyhledávání: '"M J Flens"'
Publikováno v:
Gastroenterology Research and Practice, Vol 2017 (2017)
Aim. Extramural venous invasion (EMVI) is a prognostic indicator in patients with colorectal cancer. However, its additional value in patients with stage 1 and 2 colorectal cancer is uncertain. In the present study, the incidence of EMVI and the haza
Externí odkaz:
https://doaj.org/article/8ab79c5b62794bebab6e63f930ab12a3
Autor:
A Monks, Miguel Izquierdo, M C de Jong, M. J. Flens, George L. Scheffer, Robert H. Shoemaker, R.J. Scheper, C D Hose
Publikováno v:
British Journal of Cancer
The rat monoclonal antibody LMR-12 was shown earlier to react with a plasma membrane protein, upregulated in multidrug-resistant cell lines. In this study, we observed distinct LMR-12 staining in 36 out of 55 non-drug-selected tumour cell lines, incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b7b9014b9df26a6f8adabe27fb09f8
https://doi.org/10.1038/sj.bjc.6600354
https://doi.org/10.1038/sj.bjc.6600354
Autor:
Doris Mayr, Gustavo Baretton, Rik J. Scheper, Joachim Diebold, Martina Gropp, M. J. Flens, Uwe Pannekamp, W Meier
Publikováno v:
Pathology - Research and Practice. 196:469-475
Loss of function of the tumor suppressor gene p53, increased expression of glutathione-S-transferase pi (GST7pi) and the major vault protein are involved in drug resistance of ovarian carcinomas. However, a study comparing these factors has not yet b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097bd541369cb3874d86390ec1d5e91d
https://doi.org/10.1016/s0344-0338(00)80048-5
https://doi.org/10.1016/s0344-0338(00)80048-5
Autor:
Gerrit A. Meijer, R.J. Scheper, P. van der Valk, J. P. A. Baak, M. J. Flens, S. G. M. Meuwissen, A. B. Schroeijers
Publikováno v:
Meijer, G A, Schroeijers, A B, Flens, M J, Meuwissen, S G M & Baak, J P A 1999, ' Increased expression of multidrug resistance related proteins Pgp, MRP1, and LRP/MVP occurs early in colorectal carcinogenesis ', Journal of Clinical Pathology, vol. 52, pp. 450-454 . https://doi.org/10.1136/jcp.52.6.450
Journal of Clinical Pathology, 52, 450-454. BMJ Publishing Group
Journal of Clinical Pathology, 52, 450-454. BMJ Publishing Group
AIM: To analyse the expression of multidrug resistance (MDR) related proteins at different steps in colorectal carcinogenesis. METHODS: The presence of three MDR related proteins (Pgp, MRP1, and LRP/MVP) was studied by means of immunohistochemistry i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ca1b0554cd709764d7b1cf834a008e
https://doi.org/10.1136/jcp.52.6.450
https://doi.org/10.1136/jcp.52.6.450
Autor:
Christian M. Zwaan, M L den Boer, R. Pieters, K. M. Kazemier, M. M. A. Rottier, R.J. Scheper, M. J. Flens, A. J. P. Veerman
Publikováno v:
den Boer, M L, Zwaam, C M, Pieters, R, Kazemier, K M, Rottier, M M A, Flens, M J, Scheper, R J & Veerman, A J P 1997, ' Optimal immunoctochemical and flow cytometricd detection of P-gp, MRP and LRP in childhood acute lymphoblastic leukemia ', Leukemia, vol. 11, pp. 1078-1085 . https://doi.org/10.1038/sj.leu.2400729
Leukemia, 11, 1078-1085. Nature Publishing Group
Leukemia, 11, 1078-1085. Nature Publishing Group
The clinical relevance of multidrug resistance (MDR)-related proteins in childhood acute lymphoblastic leukemia (ALL) is largely unknown. The diversity of techniques, fixation methods, storage of cells (fresh or cryopreserved) etc, may contribute to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de9f86da722161eebfb9d9eb47cc967
https://doi.org/10.1038/sj.leu.2400729
https://doi.org/10.1038/sj.leu.2400729
Autor:
K. E. Van Wingerden, J.G.M. Klijn, G. Stoter, Maxime P. Look, K. Nooter, G. Brutel De La Riviere, S. C. Henzen-Logmans, J.A. Foekens, M. J. Flens, R.J. Scheper
Publikováno v:
British Journal of Cancer
British Journal of Cancer, 76(4), 486-493. Nature Publishing Group
British Journal of Cancer, 76(4), 486-493. Nature Publishing Group
In the present study, we determined the frequency and intensity of MRP protein expression by monoclonal antibody immunohistochemistry in a series of 259 resected invasive primary breast carcinomas, and we evaluated MRP immunoreactivity in relation to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430d202f49c5390ebade6f6315f7ac2b
http://europepmc.org/articles/PMC2227995
http://europepmc.org/articles/PMC2227995
Autor:
Miguel A. Izquierdo, Jacques Neefjes, George L. Scheffer, A. E. L. Mathari, R.J. Scheper, M. J. Flens
Publikováno v:
British Journal of Cancer
Multidrug resistance (MDR) to anti-cancer drugs has been associated with the overexpression of P-glycoprotein (P-gp) and the multidrug resistance-associated protein (MRP), both being members of the ATP-binding cassette (ABC) superfamily of transporte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d18638c4ad5b4f479c35f2e2ac6ba270
https://doi.org/10.1038/bjc.1996.660
https://doi.org/10.1038/bjc.1996.660
Autor:
Herbert M. Pinedo, Rik J. Scheper, A.-M. C. Dingemans, M. J. Flens, Adi F. Gazdar, Giuseppe Giaccone, G. Rubio, Jannette van Ark-Otte, Henk J. Broxterman
Publikováno v:
International Journal of Cancer. 66:760-767
The multidrug resistance-associated protein (MRP), a new membrane transporter related to non-Pgp multidrug resistance, is overexpressed in some drug-selected cancer-cell lines. The role of MRP in unselected cell lines and in human cancer is unknown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0fb8c0ff8355aa2fedd0a783427d755
https://doi.org/10.1002/(sici)1097-0215(19960611)66:6<760::aid-ijc9>3.0.co
https://doi.org/10.1002/(sici)1097-0215(19960611)66:6<760::aid-ijc9>3.0.co
Autor:
M. J. Flens, Piet Borst, R.J. Scheper, C. H. M. Versantvoort, E. Kamst, Guido J.R. Zaman, M. De Haas, Frank Baas, E. W. H. M. Eijdems
Publikováno v:
British Journal of Cancer
Scopus-Elsevier
British journal of cancer, 72(2), 298-306. Nature Publishing Group
Scopus-Elsevier
British journal of cancer, 72(2), 298-306. Nature Publishing Group
We have analysed the contribution of several parameters, e.g. drug accumulation, MDR1 P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP) and topoisomerase (topo) II, to drug resistance in a large set of drug-resistant variants of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ede8371279e06bc978437f09cb56d53
https://doi.org/10.1038/bjc.1995.328
https://doi.org/10.1038/bjc.1995.328
Autor:
M. R. Van Leusden, Jan Lankelma, Rik J. Scheper, M. De Haas, H. J. Broxterman, M. J. Flens, Frank Baas, H.S. Mülder, Piet Borst, G. J. R. Zaman, Herbert M. Pinedo
Publikováno v:
Zaman, G J R, Flens, M J, van Leusden, M R, de Haas, M, Mülder, H S, Lankelma, J, Pinedo, H M, Scheper, R J, Baas, F, Broxterman, H J & Borst, P 1994, ' The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump ', Proceedings of the National Academy of Sciences, vol. 91 .
Proceedings of the National Academy of Sciences, 91
Proceedings of the National Academy of Sciences of the United States of America, 91(19), 8822-8826. National Academy of Sciences
Proceedings of the National Academy of Sciences, 91
Proceedings of the National Academy of Sciences of the United States of America, 91(19), 8822-8826. National Academy of Sciences
The multidrug-resistance associated protein MRP is a 180- to 195-kDa membrane protein associated with resistance of human tumor cells to cytotoxic drugs. We have investigated how MRP confers drug resistance in SW-1573 human lung carcinoma cells by ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0bb9418521dadf33ca4f26029870b98
https://doi.org/10.1073/pnas.91.19.8822
https://doi.org/10.1073/pnas.91.19.8822