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Autor: M J, Elices

Publikováno v: IDrugs : the investigational drugs journal. 1(2)

AN-100226 (Antegren), a humanized monoclonal antibody (MAb) directed against the alpha4beta1 integrin (VLA-4) expressed on leukocytes, is under development by Athena Neurosciences as a potential treatment of exacerbations in multiple sclerosis (MS).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cb17ec4d6522b1be36ae74141e9f2991
https://pubmed.ncbi.nlm.nih.gov/18465535

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Extracellular matrix proteins expressed by human adult astrocytes in vivo and in vitro: an astrocyte surface protein containing the CS1 domain contributes to binding of lymphoblasts

Autor: L J, van der Laan, C J, De Groot, M J, Elices, C D, Dijkstra

Publikováno v: Journal of neuroscience research. 50(4)

Primary cultures of human astrocytes, expressing glial fibrillary acidic protein (GFAP), were obtained from postmortem brain tissue samples. These cultured astrocytes produced an extracellular matrix (ECM), containing laminin (Ln) and fibronectin (Fn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4f0e4b40f5375c0b71fb149a5486ad07
https://pubmed.ncbi.nlm.nih.gov/9404716

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Alternatively spliced CS-1 fibronectin isoform and its receptor VLA-4 in rheumatoid arthritis synovium

Autor: U, Müller-Ladner, M J, Elices, J B, Kriegsmann, D, Strahl, R E, Gay, G S, Firestein, S, Gay

Publikováno v: The Journal of rheumatology. 24(10)

Extracellular matrix components and cell adhesion molecules play a role in the pathogenesis of rheumatoid arthritis (RA). Interaction between the integrin very late antigen-4 (VLA-4) and the connecting segment-1 (CS-1) fibronectin (FN) isoform may co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d2ac281665db6ac0263c026dc5d5c1e2
https://pubmed.ncbi.nlm.nih.gov/9330926

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The integrin alpha 4 beta 1 (VLA-4) as a therapeutic target

Autor: M J, Elices

Publikováno v: Ciba Foundation symposium. 189

Disease models in animals demonstrate that the leukocyte integrin alpha 4 beta 1 (VLA-4) is a suitable target for therapy in a number of chronic inflammatory disorders. While in vivo studies have concentrated on the use of anti-alpha 4 antibodies as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c14aa8514ce9d912e1beb7bb284de623
https://pubmed.ncbi.nlm.nih.gov/7587639

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The integrin VLA-4 mediates leukocyte recruitment to skin inflammatory sites in vivo

Autor: M J, Elices, S, Tamraz, V, Tollefson, L W, Vollger

Publikováno v: Clinical and experimental rheumatology. 11

We have developed a murine model of delayed type hypersensitivity (DTH) to the chemical oxazalone. Purification of T lymphocytes from immunized animals allows adoptive transfer of the specific DTH response into naive recipients injected intravenously

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9da0c82e14761900b211f6d36a902e92
https://pubmed.ncbi.nlm.nih.gov/8324956

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Multiple ligand binding functions for VLA-2 (alpha 2 beta 1) and VLA-3 (alpha 3 beta 1) in the integrin family

Autor: M E, Hemler, M J, Elices, B M, Chan, B, Zetter, N, Matsuura, Y, Takada

Publikováno v: Cell differentiation and development : the official journal of the International Society of Developmental Biologists. 32(3)

In our studies of VLA-3 we have shown (i) that a single integrin (VLA-3) can bind to multiple ligands by different mechanisms, involving RGD and non-RGD sites, which are regulated differently by divalent cations. Also we showed from the primary seque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ac8d56233269042d0eeea15d2faf8424
https://pubmed.ncbi.nlm.nih.gov/1965952

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Ehrlich ascites tumor cell UDP-Gal:N-acetyl-D-glucosamine beta(1,4)-galactosyltransferase. Purification, characterization, and topography of the acceptor-binding site

Autor: Irwin J. Goldstein, M J Elices

Publikováno v: Journal of Biological Chemistry. 263:3354-3362

A UDP-Gal:N-acetylglucosamine beta(1,4)-galactosyltransferase which catalyzes the synthesis of beta-D-Gal(1,4)-D-GlcNAc units has been purified 17,560-fold from Ehrlich tumor cells to apparent electrophoretic homogeneity. The enzyme appears to be a m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6659c1dee6a2151739b8ea014c7dd7ca
https://doi.org/10.1016/s0021-9258(18)69079-9

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Purification and characterization of a UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase from Ehrlich ascites tumor cells

Autor: Irwin J. Goldstein, D A Blake, M J Elices

Publikováno v: Journal of Biological Chemistry. 261:6064-6072

A UDP-Gal:N-acetyllactosaminide alpha (1,3)-galactosyltransferase from Ehrlich ascites tumor cells has been purified over 200,000-fold to apparent electrophoretic homogeneity. The purified enzyme transfers D-galactosyl groups from UDP-Gal to beta-D-G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ea8244948048051b9b6a07a6e0105f2
https://doi.org/10.1016/s0021-9258(17)38493-4

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Purification and characterization of a UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase from Ehrlich ascites tumor cells

Autor: M J, Elices, D A, Blake, I J, Goldstein

Publikováno v: The Journal of biological chemistry. 261(13)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5dba136122117be5de3d939c2481bffc
https://pubmed.ncbi.nlm.nih.gov/3084477

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