The fidelity of DNA replication, particularly on GC-rich templates, is reduced by defects of the Fe–S cluster in DNA polymerase δ

Autor: Elena I. Stepchenkova, Piotr A. Mieczkowski, Thomas A. Kunkel, Adam B. Burkholder, Thomas D. Petes, Denis A. Kiktev, Peter M. J. Burgers, Margaret Dominska, Joseph Dahl, Scott A. Lujan, Tony Zhang

Publikováno v: Nucleic Acids Research

Iron-sulfur clusters (4Fe–4S) exist in many enzymes concerned with DNA replication and repair. The contribution of these clusters to enzymatic activity is not fully understood. We identified the MET18 (MMS19) gene of Saccharomyces cerevisiae as a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8d3cda85e55d05e987d2244cf4b037
http://europepmc.org/articles/PMC8191807

Activation of Tel1ATM kinase requires Rad50 ATPase and long nucleosome-free DNA but no DNA ends

Autor: Peter M. J. Burgers, Sarem Hailemariam, Sandeep Kumar

Publikováno v: Journal of Biological Chemistry. 294:10120-10130

In Saccharomyces cerevisiae, Tel1 protein kinase, the ortholog of human ataxia telangiectasia–mutated (ATM), is activated in response to DNA double-strand breaks. Biochemical studies with human ATM and genetic studies in yeast suggest that recruitm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9999fb4418515255cd09dc3c0a0382f8
https://doi.org/10.1074/jbc.ra119.008410

Gamification in Dutch businesses: An explorative case study

Autor: M. J. Burgers, R. C. P. M. Van den Ouweland, A. M. Kaan, B. I. J. M. Van der Heijden, T. Meijer, B. F. Lamberts, Koen Migchelbrink

Publikováno v: Sage Open, 10
SAGE Open
Sage Open, 10, 4, pp. 1-13
SAGE Open, Vol 10 (2020)
SAGE OPEN
Sage Open, 10, 1-13
Van der Heijden, B I J M, Burgers, M J, Kaan, A M, Lamberts, B F, Migchelbrink, K, Van den Ouweland, R C P M & Meijer, T 2020, ' Gamification in Dutch Businesses : An Explorative Case Study ', Sage Open, vol. 10, no. 4, pp. 1-13 . https://doi.org/10.1177/2158244020972371
Sage Open, 10, 4
Sage Open, 10(4), 1-13. SAGE Publications Inc.
SAGE Open, 10(4), 1-13. SAGE Publishing

Contains fulltext : 225023.pdf (Publisher’s version ) (Open Access) An in-depth case study approach was followed and data were collected by means of nine semi-structured interviews with experts from six case organizations. Our findings indicate tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::595be226514bc26e97a3cce8a002187b
http://hdl.handle.net/2066/225023

Pif1, RPA, and FEN1 modulate the ability of DNA polymerase δ to overcome protein barriers during DNA synthesis

Autor: Melanie A. Sparks, Peter M. J. Burgers, Roberto Galletto

Publikováno v: J Biol Chem

Successful DNA replication requires carefully regulated mechanisms to overcome numerous obstacles that naturally occur throughout chromosomal DNA. Scattered across the genome are tightly bound proteins, such as transcription factors and nucleosomes,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec8dac80f534bb5900ff8b74283b7fb
https://pubmed.ncbi.nlm.nih.gov/32913126

A rare case of Waldenström's macroglobulinaemia-associated cryoglobulinaemia vasculitis

Autor: M M J, Burgers, J A A, Meijer, E J H M, van de Weijgert, E, de Jongh

Publikováno v: The Netherlands journal of medicine. 78(2)

This case report presents a patient with vasculitis as a presenting symptom of type I cryoglobulinaemia due to lymphoproliferative disease. This is an uncommon cause of vasculitis, but important to recognise, as it influences treatment decisions. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::920126f90d332272852857b528f29283
https://pubmed.ncbi.nlm.nih.gov/32332173