Zobrazeno 1 - 10 of 21 pro vyhledávání: '"M J Bradbury"'
1
The effect of potent CYP2D6 inhibition on the pharmacokinetics and safety of deutetrabenazine in healthy volunteers
Autor: F. Schneider, P. S. Loupe, L. Rabinovich-Guilatt, M. F. Gordon, D. Stamler, M. J. Bradbury
Publikováno v: European Journal of Clinical Pharmacology
Purpose Deutetrabenazine is a deuterated form of tetrabenazine with a confirmed lower rate of CYP2D6 metabolism of the active metabolites, α- and β-HTBZ. In this study, we assessed the effect of paroxetine, a potent CYP2D6 inhibitor, on the pharmac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd84a87777c1f82f5039ff8334c24a4c
https://pubmed.ncbi.nlm.nih.gov/34491372
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3
Clamped Corticosterone (B) Reveals the Effect of Endogenous B on Both Facilitated Responsivity to Acute Restraint and Metabolic Responses to Chronic Stress
Autor: M J Bradbury, C. J. Horsley, A. M. Strack, Mary F. Dallman, Erin D. Milligan, Seema Bhatnagar, E S Hanson, Susan F. Akana
Publikováno v: Stress. 1:33-49
To determine the effects of both corticosterone (B) and chronic stressors on acute ACTH responses to restraint, young male rats were exposed to streptozotocin-induced diabetes, cold (5-7 degreesC) or intracerebroventricular (icv) neuropeptide Y (NPY)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a27833f54b9ae1a98eb1e44f5bca13
https://doi.org/10.3109/10253899609001094
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4
Corticosterone decreases nonshivering thermogenesis and increases lipid storage in brown adipose tissue
Autor: A. M. Strack, Mary F. Dallman, M J Bradbury
Publikováno v: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 268:R183-R191
Brown adipose tissue (BAT) contains glucocorticoid receptors; glucocorticoids are required for maintaining differentiated BAT in culture. These studies were performed to determine the effects of corticosterone on BAT thermogenic function and lipid st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a632e1afbdd91c3b54976c61549fbc
https://doi.org/10.1152/ajpregu.1995.268.1.r183
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5
Regulation of the hypothalamo-pituitary-adrenal axis during stress: feedback, facilitation and feeding
Autor: Susan F. Akana, M J Bradbury, Karen A. Scribner, A. M. Strack, Mary F. Dallman, E. Simon Hanson
Publikováno v: Seminars in Neuroscience. 6:205-213
Stressors stimulate the release of corticotropin-releasing factor and/or vasopressin from the hypothalamic paraventricular nuclei causing secretion of adrenocorticotropin from the pituitary and corticosteroids from the adrenal cortex. Corticosteroids
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f815902756cb37a49c602f338db8be9b
https://doi.org/10.1006/smns.1994.1027
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6
The diurnal rhythm in adrenocorticotropin responses to restraint in adrenalectomized rats is determined by caloric intake
Autor: Susan F. Akana, M J Bradbury, K S Scribner, A. M. Strack, Mary F. Dallman, E S Hanson
Publikováno v: Endocrinology. 134:2214-2220
There is a diurnal rhythm in ACTH responses to stressors that peaks, in nocturnally feeding rats, at the time of lights on, in the morning (AM). To determine whether this rhythm is subordinate to the rhythm in food intake, we tested the effects of re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acca7c7c42a82518c61b40855c817aaf
https://doi.org/10.1210/endo.134.5.8156924
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7
Glucocorticoid deficiency increases phospholipase A2 activity in rats
Autor: Brigitte M. Frey, Mary F. Dallman, Felix J. Frey, Bannikuppe S. Vishwanath, M J Bradbury
Publikováno v: Journal of Clinical Investigation. 92:1974-1980
An important mechanism for the antiinflammatory effect of pharmacological doses of glucocorticoids is the inhibition of arachidonic acid release from phospholipids by phospholipase A2 (PLA2). As a corollary, one might predict that low endogenous conc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c7905e7a7a194151cbd39693f588c7
https://doi.org/10.1172/jci116791
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8
Controlled coloration: a success strategy for the dyeing of cellulosic fibres with reactive dyes
Autor: M J Bradbury, D A S Phillips, P S Collishaw
Publikováno v: Journal of the Society of Dyers and Colourists. 109:284-292
The impact of improving the rate of right-first-time production on productivity and profitability for a batchwise dyehouse processing cellulosic fibres is reviewed. The measurement and level of performance required from reactive dyes to support right
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::018f074dea934af1c69eb00f8afeef75
https://doi.org/10.1111/j.1478-4408.1993.tb01577.x
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9
Lesions of the Hippocampal Efferent Pathway (Fimbria-Fornix) Do Not Alter Sensitivity of Adrenocorticotropin to Feedback Inhibition by Corticosterone in Rats
Autor: Mary F. Dallman, Alison M. Strack, M J Bradbury
Publikováno v: Neuroendocrinology. 58:396-407
The hypothalamic-pituitary-adrenal (HPA) axis controls the diurnal and stress-induced release of adrenal corticosteroids into the general blood circulation. In turn, corticosteroids inhibit the HPA axis under basal conditions and during stress throug
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1842e54e7a86e9709d294a86d5ccdc49
https://doi.org/10.1159/000126569
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