Zobrazeno 1 - 5
of 5
pro vyhledávání: '"M J, Verhaar"'
Autor:
KA Chester, N. Cushen, M.P. Napier, Robert E. Hawkins, Joanne L. Casey, Andrew J.W. Hilson, Richard H. J. Begent, CJ Johnson, L.D Hope‐Stone, M. J. Verhaar, Lisa Robson, AJ Green, P. A. Keep
Publikováno v:
Nature Medicine. 2:979-984
We present a system for cancer targeting based on single-chain Fv (scFv) antibodies selected from combinatorial libraries, produced in bacteria and purified by using an engineered tag. Combinatorial libraries of scFv genes contain great diversity, an
Autor:
Lisa Robson, P. A. Keep, KA Chester, M. J. Verhaar, Robert E. Hawkins, Richard H. J. Begent, J. A. Boden, RB Pedley
Publikováno v:
International Journal of Cancer. 61:497-501
Single-chain antibodies (scFvs) can be derived from a monoclonal antibody (MAb) or produced directly using filamentous phage technology, where antibodies with desired binding and purification characteristics can be readily selected from libraries. To
Publikováno v:
European journal of gynaecological oncology. 22(6)
The treatment of "high risk" persistent trophoblastic disease (PTD) consists of poly-chemotherapy. This policy probably will lead to overtreatment of some patients. Also, familiar molar pregnancies through the paternal line are unknown in the literat
Autor:
M J, Verhaar, P A, Keep, R E, Hawkins, L, Robson, J L, Casey, B, Pedley, J A, Boden, R H, Begent, K A, Chester
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 37(5)
Single-chain Fv (scFv) antibody fragments have potential for clinical imaging because of their rapid tumor penetration and high tumor-to-tissue ratios at early time points. ScFvs clear rapidly from the circulation so radiolabels such as 99mTc which h