Immune responses against human papillomavirus (HPV) type 16 virus-like particles in a cohort study of women with cervical intraepithelial neoplasia. I. Differential T-helper and IgG responses in relation to HPV infection and disease outcome

Autor: R.J. Scheper, Theo J.M. Helmerhorst, J. M. M. Walboomers, R.H.M. Verheijen, M. J. Stukart, Esther W. M. Kueter, T. D. De Gruijl, Peter L. Stern, Pierre Coursaget, C. Dupuy, Margaret F Duggan-Keen, C. J. L. M. Meijer, H. J. Bontkes

Publikováno v: Journal of General Virology
Journal of General Virology, Microbiology Society, 1999, 80 (2), pp.399-408. ⟨10.1099/0022-1317-80-2-399⟩
Journal of General Virology, 80, 399-408. Microbiology Society
de Gruijl, T D, Bontkes, H J, Walboomers, J M, Coursaget, P, Stukart, M J, Dupuy, C, Kueter, E, Verheijen, R H, Helmerhorst, T J, Duggan-Keen, M F, Stern, P L, Meijer, C J & Scheper, R J 1999, ' Immune responses against human papillomavirus (HPV) type 16 virus-like particles in a cohort study of women with cervical intraepithelial neoplasia. I. Differential T-helper and IgG responses in relation to HPV infection and disease outcome ', Journal of General Virology, vol. 80 ( Pt 2), pp. 399-408 . https://doi.org/10.1099/0022-1317-80-2-399
Journal of General Virology, 80 ( Pt 2), 399-408. Society for General Microbiology

T-helper (Th) cell-dependent IL-2 production and plasma IgG responses to virus-like particles consisting of the human papillomavirus type 16 (HPV-16) major capsid protein L1 (L1-VLP) were determined in patients with cytological evidence of cervical i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a25aed73106e928eae8a865ce65e67
https://doi.org/10.1099/0022-1317-80-2-399

Differences in MHC and TAP-1 expression in cervical cancer lymph node metastases as compared with the primary tumours

Autor: Theo J.M. Helmerhorst, M. J. Stukart, P. F. J. van Bommel, J. M. M. Walboomers, F. V. Cromme, C. J. L. M. Meijer, Maarten P.W. Gallee, Peter Kenemans, Peter L. Stern

Publikováno v: British Journal of Cancer

In previous studies we have shown down-regulation of class I major histocompatibility complex (MHC) expression in a significant proportion of primary cervical carcinomas, which was found to be strongly correlated with loss of expression of the transp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9209e5e32fded7dcac974230fc60effe
https://doi.org/10.1038/bjc.1994.231

Human papillomavirus type 16 E6/E7-specific cytotoxic T lymphocytes in women with cervical neoplasia

Autor: H J, Bontkes, T D, de Gruijl, A J, van den Muysenberg, R H, Verheijen, M J, Stukart, C J, Meijer, R J, Scheper, S N, Stacey, M F, Duggan-Keen, P L, Stern, S, Man, L K, Borysiewicz, J M, Walboomers

Publikováno v: International journal of cancer. 88(1)

Infection with oncogenic human papillomavirus (HPV) types is associated with the development of cervical neoplasia (CIN). The E6 and E7 oncoproteins are constitutively expressed in these lesions and are therefore putative targets for the immune respo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d5f10c28b6b5266368474dfc8b186cc6
https://pubmed.ncbi.nlm.nih.gov/10962445

Differential T helper cell responses to human papillomavirus type 16 E7 related to viral clearance or persistence in patients with cervical neoplasia: a longitudinal study

Autor: T D, de Gruijl, H J, Bontkes, J M, Walboomers, M J, Stukart, F S, Doekhie, A J, Remmink, T J, Helmerhorst, R H, Verheijen, M F, Duggan-Keen, P L, Stern, C J, Meijer, R J, Scheper

Publikováno v: Cancer research. 58(8)

T-cell-mediated immune responses against oncogenic human papillomaviruses (HPVs) are believed to play a role in the prevention of cervical carcinogenesis. The in vitro production of interleukin 2 by CD4+ T helper (Th) cells in response to overlapping

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::050473b038e4115b535d7fca05c4fa44
https://pubmed.ncbi.nlm.nih.gov/9563486

Analysis of IgG reactivity against Human Papillomavirus type-16 E7 in patients with cervical intraepithelial neoplasia indicates an association with clearance of viral infection: results of a prospective study

Autor: T D, de Gruijl, H J, Bontkes, J M, Walboomers, M J, Stukart, A A, Robbesom, B M, von Blomberg-van der Flier, P, Herbrink, A J, Remmink, R H, Verheijen, T J, Helmerhorst, C J, Meijer, R J, Scheper

Publikováno v: International journal of cancer. 68(6)

IgG reactivity against the immunodominant region aa6-35 of Human Papillomavirus (HPV) type-16 E7 was determined in a peptide-based ELISA in a cohort study of women with initial mild to moderate cervical dyskaryosis. On the basis of HPV DNA patterns,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::faf5216714f4ab1a8c95fde62eba888d
https://pubmed.ncbi.nlm.nih.gov/8980175