Zobrazeno 1 - 10
of 18
pro vyhledávání: '"M J, Staruch"'
Publikováno v:
The Journal of Immunology. 152:992-1003
Rapamycin (RAP) inhibits several biologic responses in the YAC-1 T cell lymphoma, including the serum-driven proliferation and cyclin A mRNA expression, the induction of Ly-6E Ag expression by IFN, and the induction of IFN-gamma production by IL-1. R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb73bcb99fc11f7edc18cb169594a0a9
https://doi.org/10.4049/jimmunol.152.3.992
https://doi.org/10.4049/jimmunol.152.3.992
Publikováno v:
The Journal of Immunology. 144:1418-1424
The structurally related immunosuppressive macrolides FK-506 and rapamycin (RAP) were previously shown to inhibit T cell stimulation through different mechanisms. FK-506 acts similarly to cyclosporin A (CsA) and prevents IL-2 production and IL-2R exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c307bc60c4b83a57803310943b28ffa
https://doi.org/10.4049/jimmunol.144.4.1418
https://doi.org/10.4049/jimmunol.144.4.1418
Publikováno v:
The Journal of Immunology. 144:251-258
FK-506 and the structurally related macrolide rapamycin (RAP) were investigated in comparison with cyclosporin A (CsA) for their immunosuppressive effects on murine T cells. All three agents suppressed the proliferation of splenic T cells triggered b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc047e7efdeabe52480934662bffb750
https://doi.org/10.4049/jimmunol.144.1.251
https://doi.org/10.4049/jimmunol.144.1.251
Autor:
F J, Dumont, H, Ok, S, Lin, C A, Kastner, J, Cryan, M M, Martin, G, Wiederrecht, M J, Staruch
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 276(3)
FK-506 blocks T cell activation by preventing lymphokine gene transcription through formation of a complex with FKBP12 that inhibits calcineurin phosphatase activity. Immunosuppressive FK-506 analogs (agonists) have been generated whose potency corre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3e83efc7f7669392b0d922571c1aee74
https://pubmed.ncbi.nlm.nih.gov/8786538
https://pubmed.ncbi.nlm.nih.gov/8786538
Publikováno v:
Transplantation proceedings. 23(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::400ea1d0ed744d6c843b4bc3aad1f831
https://pubmed.ncbi.nlm.nih.gov/1721300
https://pubmed.ncbi.nlm.nih.gov/1721300
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 144(10)
The YAC T cell lymphoma normally does not express Ly-6E mRNA or Ly-6E surface molecules but can be induced to do so on incubation with either IFN-gamma or IFN-alpha/beta. This system afforded a model to assess the possible role of protein kinase C (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9d973a1d99669cfc7069ba279e349682
https://pubmed.ncbi.nlm.nih.gov/1692061
https://pubmed.ncbi.nlm.nih.gov/1692061
Autor:
D D Wood, E K Bayne, M B Goldring, M Gowen, D Hamerman, J L Humes, E J Ihrie, P E Lipsky, M J Staruch
Publikováno v:
The Journal of Immunology. 134:895-903
The supernatants of human monocytes incubated with endotoxin are able to stimulate the proliferation of murine thymocytes in the presence of PHA. This is known as LAF (lymphocyte activating factor) activity and is a characteristic activity of interle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef8730cbc42b3d91583650e4b7706ea4
https://doi.org/10.4049/jimmunol.134.2.895
https://doi.org/10.4049/jimmunol.134.2.895
Publikováno v:
The Journal of Immunology. 143:1580-1583
A novel macrolide antibiotic, FK-506, isolated from Streptomyces tsukubaensis, has been shown to be a potent immunosuppressive agent in vivo and in vitro. FK-506 shares a number of immunosuppressive properties with the cyclic peptide, cyclosporin A (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9db862aaf31c3a059c1bccb756dd21d5
https://doi.org/10.4049/jimmunol.143.5.1580
https://doi.org/10.4049/jimmunol.143.5.1580
Autor:
M J Staruch, D D Wood
Publikováno v:
The Journal of Immunology. 128:155-160
The possibility that the adjuvanticity of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) is under genetic control in mice was examined. It was observed that MDP markedly enhances the secondary antibody response of BALB/c mice to bovine albumin but has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04c025ea6d2ad51f83b2286c42df27a1
https://doi.org/10.4049/jimmunol.128.1.155
https://doi.org/10.4049/jimmunol.128.1.155
Autor:
M J, Staruch, D D, Wood
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 130(5)
Interleukin 1 (IL 1) was shown to enhance in vivo secondary antibody responses of mice to a protein antigen. The activity was found to be dose and time dependent. The maximum enhancing effect was obtained with 2000 LAF units of IL 1 given 2 hr after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2bda64eeeb7e0f07832596a81f505c57
https://pubmed.ncbi.nlm.nih.gov/6601146
https://pubmed.ncbi.nlm.nih.gov/6601146