Zobrazeno 1 - 10
of 14
pro vyhledávání: '"M J, Sheardown"'
Autor:
David R. Adams, C.S. Malcolm, Richard Porter, D F Revell, H Lamb, N H Allen, M J Sheardown, K Benwell
Publikováno v:
British Journal of Pharmacology. 128:13-20
1. The goal of this study was to characterize the agonist pharmacology of human 5-HT2A, 5-HT2B and 5-HT2C (VSV) receptors expressed in CHO-K1 (Chinese hamster ovary) cells. 2. We used a fluorometric imaging plate reader (FLIPR) which allows rapid det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f4a58f38b799d198ea2cf6270b98c8e
https://doi.org/10.1038/sj.bjp.0702751
https://doi.org/10.1038/sj.bjp.0702751
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 13:183-192
Brain trauma is associated with acute functional impairment and neuronal injury. At present, it is unclear to what extent disturbances in ion homeostasis are involved in these changes. We used ion-selective microelectrodes to register interstitial po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1029be305d0b64e2565083bcb9588753
https://doi.org/10.1038/jcbfm.1993.22
https://doi.org/10.1038/jcbfm.1993.22
Autor:
K J, Stanhope, N R, Mirza, M J, Bickerdike, J L, Bright, N R, Harrington, M B, Hesselink, G A, Kennett, S, Lightowler, M J, Sheardown, R, Syed, R L, Upton, G, Wadsworth, S M, Weiss, A, Wyatt
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 299(2)
The muscarinic receptor agonist xanomeline was examined and compared with the antipsychotics clozapine and/or haloperidol in the following in vivo rat models: apomorphine-induced disruption of prepulse inhibition (PPI), amphetamine-induced hyperlocom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ddc59093d8842d760e733e85cfbd292b
https://pubmed.ncbi.nlm.nih.gov/11602695
https://pubmed.ncbi.nlm.nih.gov/11602695
Publikováno v:
Biochemical pharmacology. 62(4)
The desensitization characteristics of recombinant human 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptors (VSV and INI isoforms) stably expressed in CHO-K1 (Chinese hamster ovary) cells was investigated by calcium fluorimetry. Comparative desensitization c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1d0ebc83f1d04dc16922f88b94e132f9
https://pubmed.ncbi.nlm.nih.gov/11448452
https://pubmed.ncbi.nlm.nih.gov/11448452
Autor:
R H, Porter, K R, Benwell, H, Lamb, C S, Malcolm, N H, Allen, D F, Revell, D R, Adams, M J, Sheardown
Publikováno v:
British journal of pharmacology. 128(1)
1. The goal of this study was to characterize the agonist pharmacology of human 5-HT2A, 5-HT2B and 5-HT2C (VSV) receptors expressed in CHO-K1 (Chinese hamster ovary) cells. 2. We used a fluorometric imaging plate reader (FLIPR) which allows rapid det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::75373374779a4c56d63ed3ef8ff558b8
https://pubmed.ncbi.nlm.nih.gov/10498829
https://pubmed.ncbi.nlm.nih.gov/10498829
Autor:
M J, Sheardown, H E, Shannon, M D, Swedberg, P D, Suzdak, F P, Bymaster, P H, Olesen, C H, Mitch, J S, Ward, P, Sauerberg
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 281(2)
The analgesic effects of a series of muscarinic agonists were investigated by use of the mouse acetic acid writhing, grid-shock, hot-plate and tail-flick tests. The compounds tested were oxotremorine, pilocarpine, arecoline, aceclidine, RS86 and four
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79ecf1e43cfe545617ce8048e2834e84
https://pubmed.ncbi.nlm.nih.gov/9152396
https://pubmed.ncbi.nlm.nih.gov/9152396
Autor:
M D, Swedberg, M J, Sheardown, P, Sauerberg, P H, Olesen, P D, Suzdak, K T, Hansen, F P, Bymaster, J S, Ward, C H, Mitch, D O, Calligaro, N W, Delapp, H E, Shannon
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 281(2)
Butylthio[2.2.2] ((+)-(S)-3-(4-(Butylthio)-1,2,5-thiadiazol-3-yl)-1-azabicyclo[2.2. 2] octane) is an agonist/antagonist at muscarinic receptors. The analgesic potential of butylthio[2.2.2] was assessed in the mouse by use of the grid-shock, tail-flic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6f53abf6a2ac73b4b6897589c371673a
https://pubmed.ncbi.nlm.nih.gov/9152397
https://pubmed.ncbi.nlm.nih.gov/9152397
Autor:
H E, Shannon, M J, Sheardown, F P, Bymaster, D O, Calligaro, N W, Delapp, J, Gidda, C H, Mitch, B D, Sawyer, P W, Stengel, J S, Ward, D T, Wong, P H, Olesen, P D, Suzdak, P, Sauerberg, M D, Swedberg
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 281(2)
Butylthio[2.2.2], ((+)-(S)-3-(4-butylthio-1,2,5-thiadiazol-3-yl)-1-azabicyclo[2.2.2] octane; LY297802/NNC11-1053) is a muscarinic receptor ligand which is equiefficacious to morphine in producing antinociception. In vitro, butylthio[2.2.2] had high a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::60ea834b475d911247439bbb12b0e68f
https://pubmed.ncbi.nlm.nih.gov/9152398
https://pubmed.ncbi.nlm.nih.gov/9152398
Autor:
C. H. Mitch, F. P. Bymaster, D. O. Calligaro, S. J. Quimby, B. D. Sawyer, H. E. Shannon, J. S. Ward, P. H. Olesen, P. Sauerberg, M. J. Sheardown, P. D. Suzdak, Novo Nordisk
Publikováno v:
Alzheimer’s and Parkinson’s Diseases ISBN: 9781475791471
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01a4252f01f408f12e8bd1dde0525080
https://doi.org/10.1007/978-1-4757-9145-7_66
https://doi.org/10.1007/978-1-4757-9145-7_66
Autor:
F P, Bymaster, D T, Wong, C H, Mitch, J S, Ward, D O, Calligaro, D D, Schoepp, H E, Shannon, M J, Sheardown, P H, Olesen, P D, Suzdak, M D, Swedberg, P, Sauerberg
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 269(1)
Xanomeline [3(3-hexyloxy-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-me thylpyridine)] was evaluated in vivo in rat brain for effects on neurotransmitter turnover and inhibition of ex vivo binding of muscarinic radioligands. Xanomeline produced dose-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2e8c73d70d4629e175bfdcb422cedb42
https://pubmed.ncbi.nlm.nih.gov/7909558
https://pubmed.ncbi.nlm.nih.gov/7909558