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Akademický článek

Gas Tunnel Engineering of Prolyl Hydroxylase Reprograms Hypoxia Signaling in Cells.

Autor: Windsor P; Department of Chemistry, University of Minnesota, Twin Cities, Minneapolis, MN 55455, United States., Ouyang H; Department of Biochemistry and Molecular Biology, University of Minnesota, Twin Cities, Minneapolis, MN 55455, United States., G da Costa JA; Department of Chemistry, University of Minnesota, Twin Cities, Minneapolis, MN 55455, United States., Rama Damodaran A; Department of Chemistry, University of Minnesota, Twin Cities, Minneapolis, MN 55455, United States., Chen Y; Department of Biochemistry and Molecular Biology, University of Minnesota, Twin Cities, Minneapolis, MN 55455, United States., Bhagi-Damodaran A; Department of Chemistry, University of Minnesota, Twin Cities, Minneapolis, MN 55455, United States.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Nov 25; Vol. 63 (48), pp. e202409234. Date of Electronic Publication: 2024 Oct 21.

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Akademický článek

New Frontiers in Nonheme Enzymatic Oxyferryl Species.

Autor: Paris JC; Department of Chemistry, Carnegie Mellon University, 4400 Fifth Ave., Pittsburgh, PA, 15213, USA., Hei Cheung Y; Department of Chemistry, Boston University, 590 Commonwealth Ave., Boston, MA, 02215, USA., Zhang T; Department of Chemistry, Boston University, 590 Commonwealth Ave., Boston, MA, 02215, USA., Chang WC; Department of Chemistry, North Carolina State University, 2620 Yarbrough Dr., Raleigh, NC, 27695, USA., Liu P; Department of Chemistry, Boston University, 590 Commonwealth Ave., Boston, MA, 02215, USA., Guo Y; Department of Chemistry, Carnegie Mellon University, 4400 Fifth Ave., Pittsburgh, PA, 15213, USA.

Publikováno v: Chembiochem : a European journal of chemical biology [Chembiochem] 2024 Nov 18; Vol. 25 (22), pp. e202400307. Date of Electronic Publication: 2024 Aug 07.

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Akademický článek

Machine Learning Guided Rational Design of a Non-Heme Iron-Based Lysine Dioxygenase Improves its Total Turnover Number.

Autor: Hunter Wilson R; Department of Chemistry, University of Minnesota, Twin Cities, Minneapolis, MN-55455, United States., Diaz DJ; Department of Chemistry, Department of Computer Science, University of Texas at Austin, Austin, TX-78705, United States.; Institute for Foundations of Machine Learning, University of Texas at Austin, Austin, TX-78705, United States., Damodaran AR; Department of Chemistry, University of Minnesota, Twin Cities, Minneapolis, MN-55455, United States., Bhagi-Damodaran A; Department of Chemistry, University of Minnesota, Twin Cities, Minneapolis, MN-55455, United States.

Publikováno v: Chembiochem : a European journal of chemical biology [Chembiochem] 2024 Oct 06, pp. e202400495. Date of Electronic Publication: 2024 Oct 06.

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In vitro biosynthesis of iron-molybdenum cofactor and maturation of the nif-encoded apodinitrogenase. Effect of substitution for NifH with site-specifically altered forms of NifH

Autor: P, Rangaraj, M J, Ryle, W N, Lanzilotta, P W, Ludden, V K, Shah

Publikováno v: The Journal of biological chemistry. 274(28)

NifH has three different roles in the nitrogenase enzyme system. Apart from serving as the physiological electron donor to dinitrogenase, NifH is involved in iron-molybdenum cofactor (FeMo-co) biosynthesis and in maturation of the FeMo-co-deficient f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f45b4e384f6d43b763eebe8efa183421
https://pubmed.ncbi.nlm.nih.gov/10391920

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Electron Transfer Reactions within the Heterologous Clostridium pasteurianum Fe Protein - Azotobacter vinelandii MoFe Protein Nitrogenase Complex

Autor: Jeannine M. Chan, M. J. Ryle, L. C. Seefeldt

Publikováno v: Biological Nitrogen Fixation for the 21st Century ISBN: 9789401061698

The MoFe protein from Azotobacter vinelandii (AvI) and the Fe protein from Clostridium pasteurianum (CpII) form a tight complex with an association constant about 10-fold higher than that for the homologous A. vinelandii Fe protein (AvII) - AvI compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42b7da4d77264b9468c69f85bc09eb72
https://doi.org/10.1007/978-94-011-5159-7_21

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Circular dichroism and x-ray spectroscopies of Azotobacter vinelandii nitrogenase iron protein. MgATP and MgADP induced protein conformational changes affecting the [4Fe-4S] cluster and characterization of a [2Fe-2S] form

Autor: M J, Ryle, W N, Lanzilotta, L C, Seefeldt, R C, Scarrow, G M, Jensen

Publikováno v: The Journal of biological chemistry. 271(3)

Nucleotide interactions with nitrogenase are a central part of the mechanism of nitrogen reduction. Previous studies have suggested that MgATP or MgADP binding to the nitrogenase iron protein (Fe protein) induce protein conformational changes that co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::58582ebe55b047b681a336609269a64f
https://pubmed.ncbi.nlm.nih.gov/8576152

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Akademický článek

Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan.

Autor: Cheung-Lee WL; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Kolev JN; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., McIntosh JA; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Gil AA; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Pan W; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Xiao L; Modeling & Informatics, Discovery Chemistry, Merck & Co., Inc., Rahway, NJ 07065, USA., Velásquez JE; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Gangam R; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Winston MS; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Li S; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Abe K; Chemical Commercialization Technologies, Merck & Co., Inc., Rahway, NJ 07065, USA., Alwedi E; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Dance ZEX; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Fan H; API Process Research & Development (Biocatalysis), Shanghai STA Pharmaceutical Co., Ltd., Shanghai, 201507, China., Hiraga K; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Kim J; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Kosjek B; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Le DN; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Marzijarani NS; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Mattern K; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., McMullen JP; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Narsimhan K; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Vikram A; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Wang W; API Process Research & Development (Biocatalysis), Shanghai STA Pharmaceutical Co., Ltd., Shanghai, 201507, China., Yan JX; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Yang RS; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Zhang V; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Zhong W; Analytical Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., DiRocco DA; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Morris WJ; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Murphy GS; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Maloney KM; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Mar 22; Vol. 63 (13), pp. e202316133. Date of Electronic Publication: 2024 Feb 19.

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