Zobrazeno 1 - 10
of 64
pro vyhledávání: '"M J, Robins"'
Publikováno v:
Tetrahedron. 53:12005-12016
Ribonucleotide reductases catalyze the reduction of nucleotides to deoxynucleotides in all organisms. 2′-Ara-2′-azido-2′-deoxyadenosin-5′-triphosphate (araN 3 ATP) is a potent mechanism based inhibitor of the AdoCbl-dependent enzyme from Lact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2959d1d899e358c84bc77e523ae4b66a
https://doi.org/10.1016/s0040-4020(97)00713-8
https://doi.org/10.1016/s0040-4020(97)00713-8
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4357c224da43d12a7076a752a2bc16c6
https://doi.org/10.1002/chin.199139245
https://doi.org/10.1002/chin.199139245
Publikováno v:
ChemInform. 28
Ribonucleotide reductases catalyze the reduction of nucleotides to deoxynucleotides in all organisms. 2′-Ara-2′-azido-2′-deoxyadenosin-5′-triphosphate (araN 3 ATP) is a potent mechanism based inhibitor of the AdoCbl-dependent enzyme from Lact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efc6a30d8b7a3a0bb76698d2b6861acd
https://doi.org/10.1002/chin.199750258
https://doi.org/10.1002/chin.199750258
Publikováno v:
The Journal of organic chemistry. 66(24)
Protection (O5') of 2',3'-anhydroadenosine with tert-butyldiphenylsilyl chloride and epoxide opening with dimethylboron bromide gave the 3'-bromo-3'-deoxy xylo isomer which was treated with benzylisocyanate to give the 2'-O-(N-benzylcarbamoyl) deriva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b32218464dbea6b82dc31ddf379c57ec
https://pubmed.ncbi.nlm.nih.gov/11722226
https://pubmed.ncbi.nlm.nih.gov/11722226
Autor:
X, Lin, M J, Robins
Publikováno v:
Organic letters. 2(22)
[reaction: see text] Treatment of sugar-protected inosine and 2'-deoxyinosine derivatives with a cyclic secondary amine or imidazole and I(2)/Ph(3)P/EtN(i-Pr)(2)/(CH(2)Cl(2) or toluene) gave quantitative conversions into 6-N-(substituted)purine nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::11ac823f77d4fc2299916d634a44a3ab
https://pubmed.ncbi.nlm.nih.gov/11082018
https://pubmed.ncbi.nlm.nih.gov/11082018
Publikováno v:
The Journal of organic chemistry. 65(10)
Treatment of a 1,2-O-isopropylidene-3-ketopentofuranose derivative (obtained from D-glucose) with [(ethoxycarbonyl)methylene]triphenylphosphorane and catalytic hydrogenation of the resulting alkene gave stereodefined access to 3-(carboxymethyl)-3-deo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::44425707ea60d24d2b16055870aaad41
https://pubmed.ncbi.nlm.nih.gov/10814181
https://pubmed.ncbi.nlm.nih.gov/10814181
Publikováno v:
The Journal of biological chemistry. 274(11)
The ribonucleoside triphosphate reductase (RTPR) from Lactobacillus leichmannii catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates and uses coenzyme B12, adenosylcobalamin (AdoCbl), as a cofactor. Use of a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1f4f5f0bdd81ff25922d3a26a29c06af
https://pubmed.ncbi.nlm.nih.gov/10066759
https://pubmed.ncbi.nlm.nih.gov/10066759
Publikováno v:
The Journal of biological chemistry. 267(31)
Several 2',3'-dideoxynucleosides (ddNs), agents that inhibit the replication of human immunodeficiency virus and hepatitis B virus, enter mammalian cells by simple diffusion. In this report, we show that the membrane permeation of 2',3'-dideoxyguanos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::67ff59535a9ceb9b14eedf9ea45d1c7f
https://pubmed.ncbi.nlm.nih.gov/1429579
https://pubmed.ncbi.nlm.nih.gov/1429579
Publikováno v:
Journal of acquired immune deficiency syndromes. 3(12)
2',3'-Dideoxyinosine (DDI) and 2',3'-dideoxy-2,6-diaminopurine riboside (ddDAPR) are potent and selective inhibitors of human immunodeficiency virus (HIV) replication in MT-4 cells. They are also inhibitory to the transformation of C3H/3T3 cells by M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e1205781f861024d2534538a4314eefa
https://pubmed.ncbi.nlm.nih.gov/2123003
https://pubmed.ncbi.nlm.nih.gov/2123003
Autor:
M. J. Robins, M. MacCoss
Publikováno v:
The Chemistry of Antitumour Agents ISBN: 9789401066655
Of the plethora of pyrimidines, pyrimidine nucleosides, analogues and prodrug derivatives that have been synthesised and evaluated as anticancer agents, only two are in general clinical use. The long-studied 5-fluorouracil (5-FUra (1), see Scheme 9.1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2da8c2bf5350c903d1023c98163c4a78
https://doi.org/10.1007/978-94-009-0397-5_9
https://doi.org/10.1007/978-94-009-0397-5_9
