Zobrazeno 1 - 10
of 19
pro vyhledávání: '"M J, Pikal"'
Publikováno v:
Pharmaceutical research. 18(1)
This study aims to assess the pH changes induced by salt precipitation during far-from-equilibrium freezing of sodium phosphate buffers as a function of buffer composition, under experimental conditions relevant to pharmaceutical applications-sample
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::700604bf29ef1540cdc4049c9d48e655
https://pubmed.ncbi.nlm.nih.gov/11336359
https://pubmed.ncbi.nlm.nih.gov/11336359
Publikováno v:
Journal of pharmaceutical sciences. 89(3)
The molecular mobility of amorphous pharmaceutical materials is known to be a key factor in determining their stability, reactivity, and physicochemical properties. Usually such molecular mobility is quantified using relaxation time constants. Typica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b29165ec577cdb224c39c37edced6968
https://pubmed.ncbi.nlm.nih.gov/10707021
https://pubmed.ncbi.nlm.nih.gov/10707021
Publikováno v:
Pharmaceutical research. 15(5)
To evaluate a simple calorimetric method for estimating the fragility of amorphous pharmaceutical materials from the width of the glass transition region.The glass transition temperature regions of eleven amorphous pharmaceutical materials were chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c68bf59ca0ba0f93b4ec1a96666310a7
https://pubmed.ncbi.nlm.nih.gov/9619787
https://pubmed.ncbi.nlm.nih.gov/9619787
Autor:
M J, Pikal, D R, Rigsbee
Publikováno v:
Pharmaceutical research. 14(10)
Generalizations based upon behavior of small molecules have established that a crystalline solid is generally much more stable toward chemical degradation than is the amorphous solid. This study examines the validity of this generalization for protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9f368ac8873693d3d23ed4ac459cec85
https://pubmed.ncbi.nlm.nih.gov/9358550
https://pubmed.ncbi.nlm.nih.gov/9358550
Publikováno v:
Pharmaceutical research. 14(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aeb87c59322630a35236bb6a24e3a8c0
https://pubmed.ncbi.nlm.nih.gov/9279875
https://pubmed.ncbi.nlm.nih.gov/9279875
Publikováno v:
PDA journal of pharmaceutical science and technology. 51(1)
The objective of this study was to evaluate manometric temperature measurement as a non-invasive method of monitoring product temperature during the primary drying phase of lyophilization. This method is based on analysis of the transient response of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9dd657fd9cbc93fbb80cfe0090eb745b
https://pubmed.ncbi.nlm.nih.gov/9099059
https://pubmed.ncbi.nlm.nih.gov/9099059
Autor:
M J, Pikal, S, Shah
Publikováno v:
PDA journal of pharmaceutical science and technology. 51(1)
Particularly for proteins that may be damaged by overdrying, the distribution of residual moisture in the dried product may be as important as the mean water content. Protein at the top of the cake could be "overdried" even though the mean water cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::91b0f536ff335005ab5e315773753692
https://pubmed.ncbi.nlm.nih.gov/9099060
https://pubmed.ncbi.nlm.nih.gov/9099060
Autor:
M J, Pikal, S, Shah
Publikováno v:
Developments in biological standardization. 74
Since the stability of a freeze-dried product is often sensitive to the level of moisture, control of residual moisture by attention to the secondary drying phase of the freeze-drying process is of considerable importance. However, several reports in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::66587bc8f507e24af6bd8d868e0deafc
https://pubmed.ncbi.nlm.nih.gov/1592166
https://pubmed.ncbi.nlm.nih.gov/1592166
Publikováno v:
Developments in biological standardization. 74
This research presents the results of a series of stability studies on freeze-dried formulations of human growth hormone (hGH). Chemical decomposition via methionine oxidation and asparagine deamidation as well as irreversible aggregation are charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c01330467926d6fe83e77b8c405ae2d0
https://pubmed.ncbi.nlm.nih.gov/1592171
https://pubmed.ncbi.nlm.nih.gov/1592171
Publikováno v:
Developments in biological standardization. 74
Deacetylvinblastine (DAVLB) hydrazide, a cytotoxic vinca alkaloid, has been linked to the monoclonal antibody, KS1/4, via aldehyde residues of the oxidized carbohydrate groups on the antibody. The resulting KS1/4-DAVLB hydrazide conjugate is unstable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::88171d62c73fc5659391eeb3c4a57a4a
https://pubmed.ncbi.nlm.nih.gov/1592182
https://pubmed.ncbi.nlm.nih.gov/1592182