Výsledky vyhledávání - "M J, Oudshoorn"

The use of human in vitro metabolic parameters to explore the risk assessment of hazardous compounds: The case of ethylene dibromide

Autor: P.J. van Bladeren, L.W. Wormhoudt, Jan N. M. Commandeur, J.H.T.M. Ploemen, I de Waziers, M. J. Oudshoorn, Philippe Beaune, Nico P. E. Vermeulen, Guido R. M. M. Haenen, T. Watabe

Publikováno v: Ploemen, J P H T M, Wormhoudt, L W, Haenen, G R M M, Oudshoorn, M J, Commandeur, J N M, Vermeulen, N P E, De Waziers, I, Beaune, P H, Watabe, T & van Bladeren, P J 1997, ' The use of human in vitro metabolic parameters to explore the risk assessment of hazardous compounds: The case of ethylene dibromide. ', Toxicology and Applied Pharmacology, vol. 143, pp. 56-69 . https://doi.org/10.1006/taap.1996.8004
Toxicology and Applied Pharmacology, 143, 56-69
Toxicology and Applied Pharmacology, 143, 56-69. Academic Press Inc.
Toxicology and Applied Pharmacology 143 (1997)

Ethylene dibromide (1,2-dibromoethane, EDB) is metabolized by two routes: a conjugative route catalyzed by glutathione S -transferases (GST) and an oxidative route catalyzed by cytochrome P450 (P450). The GST route is associated with carcinogenicity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e60055c883c300fa9084d2934522198
https://hdl.handle.net/1871/24904

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Determining the best animal model for human cytochrome P450 activities : a comparison of mouse, rat, rabbit, dog, micropig, monkey and man

Autor: J.J.P. Bogaards, Peter Jackson, B. Walther, M. Bertrand, M. J. Oudshoorn, P.J. van Bladeren, Richard John Weaver

Publikováno v: Xenobiotica, 12, 30, 1131-1152

1. In the present study, nine cytochrome P450 enzyme activities in seven species were characterized to allow a practical means of comparing this important metabolic step between various test animals and man. 2. Enzyme activities and kinetic parameter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd120f0eba64e0c0de81dc6fd2710d19
http://resolver.tudelft.nl/uuid:bcc8b268-741d-4783-baae-2fbcff9930fe

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Glutathione-dependent biotransformation of the alkylating drug thiotepa and transport of its metabolite monoglutathionylthiotepa in human MCF-7 breast cancer cells

Autor: N H, Cnubben, A J, Rommens, M J, Oudshoorn, P J, Van Bladeren

Publikováno v: Cancer research. 58(20)

In this study, the role of glutathione S-transferase (GST) P1-1, the cellular reduced glutathione (GSH) status, and ATP-dependent efflux pumps in the cellular glutathione-dependent biotransformation of thiotepa and transport of the main metabolite mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a32559573266bfb311355e096e895e38
https://pubmed.ncbi.nlm.nih.gov/9788613

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Species and strain differences in the hepatic cytochrome P450-mediated biotransformation of 1,4-dichlorobenzene

Autor: A.M. Hissink, M. J. Oudshoorn, B. van Ommen, P.J. van Bladeren

Publikováno v: Toxicology and Applied Pharmacology 145 (1997)
Toxicology and Applied Pharmacology, 145, 109-109

Our goal was to characterize possible species and strain differences in the hepatic microsomal biotransformation of 1,4-dichlorobenzene (1,4-DCB). Experiments compared extent of labeled 1,4-DCB conversion to oxidized metabolites, glutathione conjugat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103345165042558da36c87c81b76e3b8
https://pubmed.ncbi.nlm.nih.gov/9221818

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Differences in cytochrome P450-mediated biotransformation of 1,2- dichlorobenzene by rat and man: Implications for human risk assessment

Autor: Guido R.M.M. Haenen, B. van Ommen, A.M. Hissink, M. J. Oudshoorn, P.J. van Bladeren

Publikováno v: Chemical Research in Toxicology, 8, 9, 1249-1256

The oxidative biotransformation of 1, 2-dichlorobenzene (1, 2-DCB) was investigated using hepatic microsomes from male Wistar, Fischer-344 and Sprague-Dawley (SD) rats, phenobarbital (PB)- and isoniazid (ISO) pretreated male Wistar rats and from man.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d77e61f58dd44e4dc0423f7a97834c2
http://resolver.tudelft.nl/uuid:8188ec52-3acb-464e-99e2-73ad6ea807d8

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Glutathione conjugation of the cytostatic drug ifosfamide and the role of human glutathione S-transferases

Autor: Luc Megens, M. A. Dingemanse, P.J. van Bladeren, M. J. Oudshoorn, Hubert Dirven, B. van Ommen

Publikováno v: Scopus-Elsevier
Chemical Research in Toxicology, 7, 8, 979-986

Development of drug resistance against alkylating cytostatic drugs has been associated with higher intracellular concentrations of glutathione (GSH) and increased expression of glutathione S-transferase (GST) enzymes. Therefore, enhanced detoxificati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c26cd7689ce000819b4e47660b4ed8ec
http://www.scopus.com/inward/record.url?eid=2-s2.0-0028872071&partnerID=MN8TOARS

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