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Establishing guidance for the handling and containment of new chemical entities and chemical intermediates in the pharmaceutical industry

Autor: M J, Olson, S P, Binks, D L, Newton, G C, Clark

Publikováno v: Occupational medicine (Philadelphia, Pa.). 12(1)

This information is intended to guide scientists and technicians working with pharmaceutical substances early in development, before occupational exposure levels (OELs) can be set. The focus is on determining hazard categories, or occupational exposu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::353fb033dd25d9240992f7c72e84ff30
https://pubmed.ncbi.nlm.nih.gov/9153052

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Isoflurane-chlorodifluoroethene interaction in human liver microsomes. Role of cytochrome P4502B6 in potentiation of haloethene metabolism

Autor: M T, Baker, M J, Olson, Y, Wang, W C, Ronnenberg, J T, Johnson, A N, Brady

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 23(1)

Short-chain saturated halocarbons, including isoflurane and the chlorofluorocarbon substitute HCFC-123, can strongly potentiate the cytochrome P450-dependent oxidation of gaseous haloethenes, such as 2-chloro-1,1-difluoroethene (CDE) and vinyl chlori

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e2bbcb8004af8db66a5103e2200a4738
https://pubmed.ncbi.nlm.nih.gov/7720526

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Interaction of fluoroethane chlorofluorocarbon (CFC) substitutes with microsomal cytochrome P450. Stimulation of P450 activity and chlorodifluoroethene metabolism

Autor: Y, Wang, M J, Olson, M T, Baker

Publikováno v: Biochemical pharmacology. 46(1)

The abilities of halothane and the fluoroethane chlorofluorocarbon (CFC) substitutes, FC-123, FC-133a, FC-124, FC-134a and FC-125, to stimulate cytochrome P450 activities and 2-chloro-1,1-difluoroethene (CDE) defluorination in hepatic microsomes from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1b689e4be9d849f92e1423d61c2fdc36
https://pubmed.ncbi.nlm.nih.gov/8347140

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Dominant role of cytochrome P-450 2E1 in human hepatic microsomal oxidation of the CFC-substitute 1,1,1,2-tetrafluoroethane

Autor: S E, Surbrook, M J, Olson

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 20(4)

The chlorofluorocarbon substitute 1,1,1,2-tetrafluoroethane (HFC-134a) is subject to metabolism by cytochrome P-450 in hepatic microsomes from rat, rabbit, and human. In rat and rabbit, the P-450 form 2E1 is a predominant low-KM, high-rate catalyst o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4e44d73366b01d0b7514cf0e0fae37e4
https://pubmed.ncbi.nlm.nih.gov/1356728

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Metabolism in vivo and in vitro of the refrigerant substitute 1,1,1,2-tetrafluoro-2-chloroethane

Autor: M J, Olson, J T, Johnson, J F, O'Gara, S E, Surbrook

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 19(5)

Ternary mixtures of hydrochlorofluorocarbons and hydrofluorocarbons are being evaluated as refrigerant substitutes for dichlorodifluoromethane, which is to be banned from further production in 2000. A priori consideration of the similarity between 1,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::80a6747388c380182ee3dccf43a74350
https://pubmed.ncbi.nlm.nih.gov/1686224

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Oxidation of 1,1,1,2-tetrafluoroethane in rat liver microsomes is catalyzed primarily by cytochrome P-450IIE1

Autor: M J, Olson, S G, Kim, C A, Reidy, J T, Johnson, R F, Novak

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 19(2)

1,1,1,2-Tetrafluoroethane (R-134a), a nonozone-depleting alternative air-conditioning refrigerant and propellant for pharmaceutical preparations, is oxidatively defluorinated by rat hepatic microsomes. In this report we show that induction of cytochr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a7ff760da25be85511298cdcff95df21
https://pubmed.ncbi.nlm.nih.gov/1676626

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Correlation between species and tissue sensitivity to chemical carcinogenesis in rodents and the induction of DNA synthesis

Autor: J E, Klaunig, J C, Siglin, L D, Schafer, J A, Hartnett, C M, Weghorst, M J, Olson, J A, Hampton

Publikováno v: Progress in clinical and biological research. 369

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::304f3ed3e4216831b98b7d5f2862c371
https://pubmed.ncbi.nlm.nih.gov/1946517

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Oxidative defluorination of 1,1,1,2-tetrafluoroethane by rat liver microsomes

Autor: M J, Olson, C A, Reidy, J T, Johnson, T C, Pederson

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 18(6)

1,1,1,2-Tetrafluoroethane (R-134a) is a non-ozone-depleting alternative to dichlorodifluoromethane for use as an air-conditioning refrigerant and as a propellant in anti-asthmatic and other pharmaceutical preparations. Hepatic microsomes, supplemente

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c11364c3f531900cf1e3f19d378653e2
https://pubmed.ncbi.nlm.nih.gov/1981550

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Modulation of glucose metabolism in isolated rat hepatocytes by 1,1,1,2-tetrafluoroethane

Autor: M J, Olson, C A, Reidy, J T, Johnson

Publikováno v: Fundamental and applied toxicology : official journal of the Society of Toxicology. 15(2)

The thermodynamic behavior and lack of ozone-depleting potential of 1,1,1,2-tetrafluoroethane (R-134a) suggest it as a likely replacement for dichlorodifluoromethane (R-12), now used as the refrigerant in many air-conditioning systems. To further the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5c904c535901525e4b62b4382b60d2f4
https://pubmed.ncbi.nlm.nih.gov/2227155

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