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A randomized, 5-arm dose finding study with a mite allergoid SCIT in allergic rhinoconjunctivitis patients

Autor: Herbert Riechelmann, Oliver Pfaar, Annette Sperl, R. van Ree, A. Roger, M. J. Nell, Serge A. Versteeg, J. D. Boot, Claus Bachert, J. N. G. Oude Elberink, Zuzana Diamant

Publikováno v: Allergy, 71(7), 967-976. Wiley-Blackwell

Background: The safety and tolerability of a mite allergoid subcutaneous allergen immunotherapy (SCIT) product was previously established. The aim of this study (EudraCT number: 2011-000393-61) was to find the optimally safe and effective allergoid d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b7764ff3683c5773a6a2a79b4cfcce1
https://doi.org/10.1111/all.12860

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Effect of endotoxin on cultured middle ear epithelium

Autor: M. J. Nell, J. J. Grote, B. M. op‘ Thof

Publikováno v: Clinical Otolaryngology and Allied Sciences. 24:377-383

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b31a42b484d7f32c78a6d29cebd385b
https://doi.org/10.1046/j.1365-2273.1999.00280-11.x

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Structural changes in the rat middle ear mucosa due to endotoxin and eustachian tube obstruction

Autor: J. J. Grote, M. J. Nell

Publikováno v: European Archives of Oto-Rhino-Laryngology. 256:167-172

The middle ears of 48 rats were used to examine the effects of endotoxin injection, eustachian tube obstruction or a combination of eustachian tube obstruction and endotoxin injection. Animals were killed after 1, 2, 4, or 12 weeks and the middle ear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::111de57d849034dd2f27c9804122cca0
https://doi.org/10.1007/s004050050134

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Inhibition of endotoxin effects on cultured human middle ear epithelium by bactericidal permeability-increasing protein

Autor: M J, Nell, B M, Albers-Op 't Hof, H K, Koerten, J J, Grote

Publikováno v: The American journal of otology. 21(5)

Endotoxin can induce morphologic changes to middle ear epithelium, which can disturb the mucociliary clearance system (MCS) and lead to otitis media with effusion (OME). The bactericidal/permeability-increasing (BPI) protein is a major component of n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ba35a0874a5d27e51d9d678eb238b13d
https://pubmed.ncbi.nlm.nih.gov/10993448

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