Zobrazeno 1 - 10
of 34
pro vyhledávání: '"M J, Losman"'
Publikováno v:
The Journal of Immunology. 154:5919-5926
A natural N-linked glycosylation site (Asn-Val-Thr) at amino acid positions 18-20 (Kabat's numbering) was identified in the framework-1 (FR-1) region of the light chain variable (V kappa) domain of a murine anti-B cell lymphoma Ab, LL-2. Our earlier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4a75c3f27bfcd952c9f652fcc464472
https://doi.org/10.4049/jimmunol.154.11.5919
https://doi.org/10.4049/jimmunol.154.11.5919
Publikováno v:
The Journal of Immunology. 148:1561-1569
MRL/Mp(-)+/+ mice produce antinuclear antibodies and develop a spontaneous autoimmune syndrome with lupus-like nephritis. We obtained a panel of seven histone-reactive IgG mAb from a single MRL/Mp(-)+/+ mouse. These antibodies do not react significan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50db706de66ef827884d09f2afbf9ac6
https://doi.org/10.4049/jimmunol.148.5.1561
https://doi.org/10.4049/jimmunol.148.5.1561
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 5
Antibody humanization has eliminated or reduced the human antimouse antibody response associated with the administration of murine antibodies. We have successfully humanized three different antibodies: (a) hMN-3 (granulocyte targeting); (b) hMu-9 (co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6445f6d5c6bb1d223b13978e38d8e896
https://pubmed.ncbi.nlm.nih.gov/10541350
https://pubmed.ncbi.nlm.nih.gov/10541350
Autor:
S O, Leung, Z, Qu, H J, Hansen, L B, Shih, J, Wang, M J, Losman, D M, Goldenberg, R M, Sharkey
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 5
Antibody (Ab) fragments are preferred agents for imaging applications because of their rapid clearance from the blood, thereby providing high tumor:blood ratios within a few hours. Several preclinical studies have also suggested that Ab fragments mig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::679dbf9a61a89c208d0f8c3e8d6718e9
https://pubmed.ncbi.nlm.nih.gov/10541351
https://pubmed.ncbi.nlm.nih.gov/10541351
Chimerization of Mu-9: a colon-specific antigen-p antibody reactive with gastrointestinal carcinomas
Publikováno v:
Cancer. 80
Mu-9 is a murine monoclonal antibody that is directed against affinity-purified colon-specific antigen-p (CSAp). CSAp is a tumor-associated antigen that is present in 60% of colorectal carcinomas. Preclinical and clinical studies have shown Mu-9 to h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1da3c3ecf1c8d5f2af23627a69728113
https://pubmed.ncbi.nlm.nih.gov/9406723
https://pubmed.ncbi.nlm.nih.gov/9406723
Autor:
M J, Losman, H J, Hansen, H, Dworak, I S, Krishnan, Z, Qu, L B, Shih, L, Zeng, D M, Goldenberg, S O, Leung
Publikováno v:
Cancer. 80
LL2 is a murine immunoglobulin (Ig)G2a-kappa anti-B-cell monoclonal antibody with proven targeting and therapeutic efficacy in the management of non-Hodgkin's lymphoma (NHL). The authors had previously generated a humanized LL2 (hLL2) that demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5edc4c556bf98efa2f55b0a5b1102a27
https://pubmed.ncbi.nlm.nih.gov/9406722
https://pubmed.ncbi.nlm.nih.gov/9406722
Autor:
M J, Losman, S O, Leung, L B, Shih, J, Shevitz, R, Shukla, L, Haraga, D M, Goldenberg, H J, Hansen
Publikováno v:
Cancer research. 55
Anti-idiotype monoclonal antibodies (Mabs) to mLL2, an anti-B-cell lymphoma and CD22-specific murine IgG2a-kappa Mab, were generated by hybridoma technology from splenocytes of Copenhagen rats immunized with mLL2 F(ab')2. Mab WN, an IgG2a-kappa, was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::75e0ee3ad892483ca77abca4199d583f
https://pubmed.ncbi.nlm.nih.gov/7493380
https://pubmed.ncbi.nlm.nih.gov/7493380
Publikováno v:
Cancer research. 55
Despite the potential advantages of 32P over other isotopes for radioimmunotherapy, its development as a therapeutic has been hindered by the difficulty of the labeling chemistry. Recently, a heptapeptide [Kemptide (KPT)] has been chemically conjugat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4448d505faf3f932fa75d9dbe1178b34
https://pubmed.ncbi.nlm.nih.gov/7493378
https://pubmed.ncbi.nlm.nih.gov/7493378
Publikováno v:
Cancer research. 55
Site-specific introduction of metal-chelating groups into F(ab')2 fragments of an antilymphoma antibody (LL2) possessing a natural Asn-linked light chain carbohydrate and an anti-carcinoembryonic antigen antibody (hImmu-14-N) grafted with a light cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6cdb4d71704ac1ce574fc33f16c0e262
https://pubmed.ncbi.nlm.nih.gov/7493334
https://pubmed.ncbi.nlm.nih.gov/7493334
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 154(11)
A natural N-linked glycosylation site (Asn-Val-Thr) at amino acid positions 18-20 (Kabat's numbering) was identified in the framework-1 (FR-1) region of the light chain variable (V kappa) domain of a murine anti-B cell lymphoma Ab, LL-2. Our earlier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5a9efd99524105508487031ef190ded7
https://pubmed.ncbi.nlm.nih.gov/7751635
https://pubmed.ncbi.nlm.nih.gov/7751635