Zobrazeno 1 - 10
of 18
pro vyhledávání: '"M J, Grusby"'
Publikováno v:
The Journal of Immunology. 153:4853-4861
The ability of the staphylococcal enterotoxins to stimulate T cells has been thought to depend on their association with class II MHC products. Here, we demonstrate that a subgroup of staphylococcal enterotoxins, which includes staphylococcal enterot
Autor:
M Bigby, J S Markowitz, P A Bleicher, M J Grusby, S Simha, M Siebrecht, M Wagner, C Nagler-Anderson, L H Glimcher
Publikováno v:
The Journal of Immunology. 151:4465-4475
MHC class I and class II molecules are essential for intrathymic maturation of a normal repertoire of alpha beta T cells. The development of gamma delta T cells may similarly require exposure to conventional MHC or MHC-like molecules for appropriate
Publikováno v:
The Journal of Immunology. 146:4011-4015
The MHC class II (Ia) molecules are heterodimeric cell surface glycoproteins that have a limited tissue distribution and are essential for an Ir. These proteins are known to both display a limited tissue distribution and be responsive to up-regulatio
Publikováno v:
The Journal of clinical investigation. 108(5)
Experimental autoimmune encephalomyelitis (EAE) is mediated by myelin-specific CD4(+) T cells secreting Th1 cytokines, while recovery from disease is associated with expression of Th2 cytokines. Investigations into the role of individual cytokines in
Autor:
M A, Exley, N J, Bigley, O, Cheng, S M, Tahir, S T, Smiley, Q L, Carter, H F, Stills, M J, Grusby, Y, Koezuka, M, Taniguchi, S P, Balk
Publikováno v:
Journal of leukocyte biology. 69(5)
A subset of CD161 (NK1) T cells express an invariant Valpha14Jalpha281 TCR-alpha chain (Valpha(invt) T cells) and produce Th2 and Th1 cytokines rapidly in response to CD1d, but their physiological function(s) remain unclear. We have found that CD1d-r
Autor:
A M, Reimold, A, Etkin, I, Clauss, A, Perkins, D S, Friend, J, Zhang, H F, Horton, A, Scott, S H, Orkin, M C, Byrne, M J, Grusby, L H, Glimcher
Publikováno v:
Genesdevelopment. 14(2)
XBP-1 is a CREB/ATF family transcription factor highly expressed in hepatocellular carcinomas. Here we report that XBP-1 is essential for liver growth. Mice lacking XBP-1 displayed hypoplastic fetal livers, whose reduced hematopoiesis resulted in dea
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(9)
Intragastric administration of soluble protein Ags results in peripheral tolerance to the fed Ag. To examine the role of cytokine regulation in the induction of oral tolerance, we fed OVA to mice deficient in Th1 (Stat 4-/-) and Th2 (Stat 6-/-) cells
Autor:
T, Hoey, M J, Grusby
Publikováno v:
Advances in immunology. 71
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(3)
IL-4 and IL-13 are the only known activators of 15-lipoxygenase (LO) expression in cultured macrophages. To determine whether these lymphocyte-derived cytokines regulate 15-LO expression in vivo, the abundance of the murine homologue (12/15-LO) was a
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(1)
Transcription of the germline C gamma1 and C epsilon Ig genes is believed to be a necessary prerequisite for isotype switching to IgG1 and IgE, respectively. IL-4 stimulation and ligation of CD40 can each independently induce low level germline gamma