Zobrazeno 1 - 3
of 3
pro vyhledávání: '"M J, Greig"'
Publikováno v:
Journal of mass spectrometry : JMS. 32(3)
The pattern of nuclease degradation observed for an antisense phosphorothioate oligonucleotide in pig kidney was determined using liquid chromatography/electrospray mass spectrometry (LC/ESI-MS) and LC/ESI-MS/MS with a quadrupole ion trap mass spectr
Autor:
S T, Crooke, M J, Graham, J E, Zuckerman, D, Brooks, B S, Conklin, L L, Cummins, M J, Greig, C J, Guinosso, D, Kornbrust, M, Manoharan, H M, Sasmor, T, Schleich, K L, Tivel, R H, Griffey
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 277(2)
Biophysical and pharmacokinetic properties of five analogs of ISIS 3082, a 20-mer phosphorothioate oligodeoxynucleotide that inhibits the expression of mouse intercellular adhesion molecule 1, were evaluated. Compared to the parent compound, ISIS 308
Publikováno v:
Rapid communications in mass spectrometry : RCM. 10(1)
The utility of negative ionization micro electrospray (microspray) mass spectrometry is demonstrated for detection of oligonucleotides and their non-covalent complexes. A simple microspray ionization source is fabricated from an outer stainless-steel