Zobrazeno 1 - 10
of 30
pro vyhledávání: '"M J, Fasco"'
Differential expression of CYP1A1 and CYP1B1 in human breast epithelial cells and breast tumor cells
Autor:
J. Q. Cao, M. J. Fasco, Brian T. Pentecost, Ying Li, J. A. Depasquale, David C. Spink, Barbara C. Spink, Thomas R. Sutter
Publikováno v:
Carcinogenesis. 19:291-298
Human cytochromes P450 1A1 (CYP1A1) and P450 1B1 (CYP1B1) catalyze the metabolic activation of a number of procarcinogens and the hydroxylation of 17beta-estradiol (E2) at the C-2 and C-4 positions, respectively. The aromatic hydrocarbon receptor (Ah
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::192b784c9465b7e0560ce9cd3cc80bb0
https://doi.org/10.1093/carcin/19.2.291
https://doi.org/10.1093/carcin/19.2.291
Autor:
M J, Fasco
Publikováno v:
Methods in molecular medicine. 26
The polymerase chain reaction (PCR) has revolutionized molecular biology. Portions of single-copy per cell genes (and cDNAs) prepared from very small tissue or cell samples can be specifically amplified for use in sequence determination, gene identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::91cb4812ef3f0ea247b78f76f0a05480
https://pubmed.ncbi.nlm.nih.gov/21340874
https://pubmed.ncbi.nlm.nih.gov/21340874
Publikováno v:
Journal of cellular biochemistry. 70(3)
Elevated expression of cytochrome P450 1B1 (CYP1B1) and estradiol 4-hydroxylation have been reported to be biomarkers of tumorigenesis in humans. The aromatic hydrocarbon receptor (AhR) regulates expression of human cytochrome P450 1A1 (CYP1A1) and C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::585f73e4b67b13b4b76a479c01265679
https://pubmed.ncbi.nlm.nih.gov/9706865
https://pubmed.ncbi.nlm.nih.gov/9706865
Publikováno v:
Cancer research. 57(13)
Allelic variants of the CYP2D6 gene, a member of the cytochrome P450 gene superfamily, have been implicated in susceptibility to lung carcinogenesis. Human breast CYP2D6 and CYP2D7P (from a pseudogene) mRNAs were previously reported to be expressed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::af6755c9c805eba7c8eee07eeedca617
https://pubmed.ncbi.nlm.nih.gov/9205060
https://pubmed.ncbi.nlm.nih.gov/9205060
Publikováno v:
Cancer research. 56(17)
Human cytochrome P4501A1 (CYP1A1) occurs extrahepatically and is polymorphic, the common form having Ile at position 462 and the rare form having Val. The rare allele has been associated with enhanced susceptibility to lung cancer. To resolve its rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::51d97556eadd5f8e4c4e5b27915f4d38
https://pubmed.ncbi.nlm.nih.gov/8752159
https://pubmed.ncbi.nlm.nih.gov/8752159
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(8)
In an effort to determine which members of the cytochrome P450 (CYP) superfamily are expressed in human breast tissue and tumors, RNA-polymerase chain reaction studies have been undertaken. Detection of expressed CYP mRNAs identifies those forms of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fab5d71903ec74658f1ab16acb470e35
https://pubmed.ncbi.nlm.nih.gov/8869826
https://pubmed.ncbi.nlm.nih.gov/8869826
Publikováno v:
Methods in enzymology. 272
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::875809aebb643af7dcc2c45f250dc912
https://pubmed.ncbi.nlm.nih.gov/8791799
https://pubmed.ncbi.nlm.nih.gov/8791799
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 23(12)
Two forms of the cytochrome P450 enzyme superfamily, P4501A1 and P4501A2, that are heterogeneously distributed in populations and are induced in response to environmental factors are important because of their capacity to bioactivate procarcinogens.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9c007c4f3a9489a1d18c302965fcfa97
https://pubmed.ncbi.nlm.nih.gov/8689941
https://pubmed.ncbi.nlm.nih.gov/8689941
Publikováno v:
Molecular pharmacology. 43(2)
Small intestinal cytochromes P450 (P450s) provide potential first-pass metabolism of ingested xenobiotics. To investigate this system, this study addresses the procedure for elution of enterocytes from male rat small intestine, histological evaluatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::87ac066fe02aa4a74fc23bc3803f573d
https://pubmed.ncbi.nlm.nih.gov/8429825
https://pubmed.ncbi.nlm.nih.gov/8429825
Publikováno v:
Journal of Biological Chemistry. 258:4372-4380
A new metabolite of vitamin K, 2(3)-hydroxy-2,3-dihydro-2-methyl,3-phytyl-1,4-naphthoquinone (hydroxyvitamin K), has been identified as a product of vitamin K epoxide metabolism in hepatic microsomes from warfarin-resistant rats, but not in those der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e39aa8188d82695ea2f0c991e4385413
https://doi.org/10.1016/s0021-9258(18)32633-4
https://doi.org/10.1016/s0021-9258(18)32633-4