Zobrazeno 1 - 10
of 199
pro vyhledávání: '"M J, Dunn"'
Publikováno v:
Nuclear Materials and Energy, Vol 25, Iss, Pp 100832-(2020)
Nuclear Materials and Energy, 25, 100832
Nuclear Materials and Energy, 25:100832. Elsevier
Nuclear Materials and Energy
Nuclear Materials and Energy, 25, 100832
Nuclear Materials and Energy, 25:100832. Elsevier
Nuclear Materials and Energy
One of the issues faced by future fusion devices will be high divertor target heat loads. Alternative divertors can promote detachment, flux expansion and dissipation mechanisms to mitigate these heat loads. They have been investigated in several dev
Publikováno v:
Neuropharmacology. 73:398-403
The 5-HT3 receptor is a cation selective member of the pentameric Cys-loop ligand-gated ion channels. While five subunits are known to exist, only two receptor subtypes have been significantly characterized: the homomeric receptor consisting of five
Publikováno v:
Future Medicinal Chemistry. 2:859-875
GABA is the major inhibitory neurotransmitter in the adult mammalian CNS. The ionotropic GABA type A receptors (GABAARs) belong to the Cys-loop family of receptors. Each member of the family is a large pentameric protein in which each subunit travers
Publikováno v:
Journal of Neurochemistry. 79:55-62
We have mutated several amino acids in the region of the GABAA receptor α1 subunit predicted to form a small extracellular loop between transmembrane domains two and three to investigate its possible role in ligand sensitivity. The mutations were S2
Publikováno v:
Biochemical and Biophysical Research Communications. 366:834-839
The nicotinic acetylcholine receptor (nAChR) from Torpedo electric organ is a pentamer of homologous subunits. This receptor is generally thought to carry two high affinity sites for agonists under equilibrium conditions. Here we demonstrate directly
Autor:
Haitao You, Susan M. J. Dunn
Publikováno v:
Journal of Neurochemistry. 103:1092-1101
We have expressed the alpha4beta3delta and alpha4beta3gamma2L subtypes of the rat GABAA receptor in Xenopus oocytes and have investigated their agonist activation properties. GABA was a more potent agonist of the alpha4beta3delta receptor (EC50 appro
Autor:
William F. Dryden, Liren Cao, Peter A. Smith, Susan M. J. Dunn, Hideki Kawai, Michael A. Raftery, Chris R. J. Carter
Publikováno v:
Biochemical Pharmacology. 73:417-426
The interactions of a series of bisholine esters [(CH 3 ) 3 N + CH 2 CH 2 OCO–(CH 2 ) n –COOCH 2 CH 2 N + (CH 3 ) 3 ] with the Torpedo nicotinic acetylcholine receptor have been investigated. In equilibrium binding studies, [ 3 H]-suberyldicholin
Publikováno v:
Neuropharmacology. 52:497-505
Fluoxetine has been reported to be a novel allosteric modulator of GABA(A) receptors with the notable exception of receptors that contain the alpha5-subunit isoform [Robinson, R.T., Drafts, B.C., Fisher, J.L., 2003. Fluoxetine increases GABA(A) recep
Publikováno v:
Journal of Neurochemistry. 88:1431-1438
GABAA receptors that contain either the α4- or α6-subunit isoform do not recognize classical 1,4-benzodiazepines (BZDs). However, other classes of BZD site ligands, including β-carbolines, bind to these diazepam-insensitive receptor subtypes. Some
Publikováno v:
Journal of Neurochemistry. 70:2188-2194
His101 of the GABA(A) receptor alpha1 subunit is an important determinant of benzodiazepine recognition and a major site of photolabeling by [3H]flunitrazepam. To investigate further the chemical specificity of the residue in this position, we substi