Zobrazeno 1 - 3
of 3
pro vyhledávání: '"M J, Dart"'
Autor:
K L, Chu, J, Xu, J, Frost, L, Li, E, Gomez, M J, Dart, M F, Jarvis, M D, Meyer, S, McGaraughty
Publikováno v:
European journal of pain (London, England). 19(5)
The noradrenergic system contributes to pain modulation, but the roles of its specific adrenoceptors are still being defined. We have identified a novel, potent (rat EC50 = 4.3 nM) and selective α2B receptor agonist, A-1262543, to further explore th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d778b563880a1b5c33dadaf116bd8c8b
https://pubmed.ncbi.nlm.nih.gov/25154730
https://pubmed.ncbi.nlm.nih.gov/25154730
Autor:
B B, Yao, G C, Hsieh, J M, Frost, Y, Fan, T R, Garrison, A V, Daza, G K, Grayson, C Z, Zhu, M, Pai, P, Chandran, A K, Salyers, E J, Wensink, P, Honore, J P, Sullivan, M J, Dart, M D, Meyer
Publikováno v:
British journal of pharmacology. 153(2)
Selective cannabinoid CB2 receptor agonists have demonstrated analgesic activity across multiple preclinical pain models. AM1241 is an indole derivative that exhibits high affinity and selectivity for the CB2 binding site and broad spectrum analgesic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6dd760bed6903261367299acc206abf4
https://pubmed.ncbi.nlm.nih.gov/17994110
https://pubmed.ncbi.nlm.nih.gov/17994110
Autor:
C-L, Chin, A E, Tovcimak, V P, Hradil, T R, Seifert, P R, Hollingsworth, P, Chandran, C Z, Zhu, D, Gauvin, M, Pai, J, Wetter, G C, Hsieh, P, Honore, J M, Frost, M J, Dart, M D, Meyer, B B, Yao, B F, Cox, G B, Fox
Publikováno v:
British journal of pharmacology. 153(2)
Activation of cannabinoid CB1 and/or CB2 receptors mediates analgesic effects across a broad spectrum of preclinical pain models. Selective activation of CB2 receptors may produce analgesia without the undesirable psychotropic side effects associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::90b3b74a0eb4370d6dfb01acb9623a86
https://pubmed.ncbi.nlm.nih.gov/17965748
https://pubmed.ncbi.nlm.nih.gov/17965748