Fibrillin-1 impairment enhances blood-brain barrier permeability and xanthoma formation in brains of apolipoprotein E-deficient mice

Autor: Lynn Roth, Jean-Pierre Timmermans, Dries Bauters, Gijs Vanhoutte, Ines Blockx, C. Van der Donckt, Wim Martinet, Isabel Pintelon, M. J Daemen, Katja Ritz, Diewertje I. Bink, G.R.Y. De Meyer, Marleen Verhoye

Publikováno v: Neuroscience. Elsevier Limited
Neuroscience, 295, 11-22. Elsevier Limited
Neuroscience
Van der Donckt, C, Roth, L, Vanhoutte, G, Blockx, I, Bink, DI, Ritz, K, Pintelon, I, Timmermans, JP, Bauters, D, Martinet, W, Daemen, M J A P, Verhoye, M & Meyer, G 2015, ' Fibrillin-1 impairment enhances blood-brain barrier permeability and xanthoma formation in brains of apolipoprotein E-deficient mice. ', Neuroscience .

We recently reported that apolipoprotein E (ApoE)-deficient mice with a mutation in the fibrillin-1 gene (ApoE(-/-)Fbn1(C1039G+/-)) develop accelerated atherosclerosis with enhanced inflammation, atherosclerotic plaque rupture, myocardial infarction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c54597ecdb33b60a68889cf558112896
https://pubmed.ncbi.nlm.nih.gov/25797463

Dynamics of cardiac wound healing following myocardial infarction: observations in genetically altered mice

Autor: W M, Blankesteijn, E, Creemers, E, Lutgens, J P, Cleutjens, M J, Daemen, J F, Smits

Publikováno v: Acta physiologica Scandinavica. 173(1)

Recent improvements in the clinical management of acute myocardial infarction (MI) have resulted in a dramatic decrease in mortality because of this condition. This implies that more patients enter the process of infarct healing. This is a highly com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f5a89db3d23d84b9d5a09c1f8c87cac8
https://pubmed.ncbi.nlm.nih.gov/11678729

[The relationship between genetic polymorphisms and disease, illustrated by the renin-angiotensin-aldosterone system and cardiovascular disease]

Autor: W, Spiering, A A, Kroon, H A, Vreugdenhil, J P, Geraedts, M J, Daemen, P W, de Leeuw

Publikováno v: Nederlands tijdschrift voor geneeskunde. 142(25)

The role of molecular genetics in the pathophysiology of various diseases is becoming clearer and clearer. In the field of cardiovascular diseases, molecular genetic aspects have been shown to play a definite role in the aetiology of these diseases.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::17a70e10bcbe484b1891e65a2ab7ba17
https://pubmed.ncbi.nlm.nih.gov/9752056

Healing human myocardial infarction associated with increased chymase immunoreactivity

Autor: M J, Daemen, H, Urata

Publikováno v: Heart and vessels.

We studied the immunoreactivity of the chymase protein in normal human myocardium and in human myocardial infarctions at various postinfarction times using immuno-histochemistry. In noninfarcted hearts chymase was mainly present in cardiomyocytes and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8bed5349ada0f1af2b9e5f20ac681362
https://pubmed.ncbi.nlm.nih.gov/9476559

Collagen remodeling after myocardial infarction in the rat heart

Autor: J P, Cleutjens, M J, Verluyten, J F, Smiths, M J, Daemen

Publikováno v: The American journal of pathology. 147(2)

In this study changes in the amount and distribution of types I and III collagen mRNA and protein were investigated in the rat heart after induction of a left ventricular myocardial infarction (MI). Sham operated rats served as controls. The animals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5ab5341c874fe9beb0828dfdde1f68bb
https://pubmed.ncbi.nlm.nih.gov/7639329