Zobrazeno 1 - 10
of 14
pro vyhledávání: '"M J, Coloma"'
Autor:
Hwa Jeong Lee, Ruben J. Boado, Atsushi Kurihara, Elliot M. Landaw, William M. Pardridge, M. J. Coloma, Sherie L. Morrison
Publikováno v:
Pharmaceutical Research. 17:266-274
Purpose. Brain drug targeting may be achieved by conjugating drugs,that normally do not cross the blood-brain barrier (BBB), to brain drugdelivery vectors. The murine 83-14 MAb to the human insulin receptor(HIR) is a potential brain drug targeting ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::091b1361199a5b4ef04c24c88b01034c
https://doi.org/10.1023/a:1007592720793
https://doi.org/10.1023/a:1007592720793
Autor:
M J Coloma, Sherie L. Morrison
Publikováno v:
Nature Biotechnology. 15:159-163
We have produced novel bispecific antibodies by fusing the DNA encoding a single chain antibody (ScFv) after the C terminus (CH3-ScFv) or after the hinge (Hinge-ScFv) with an antibody of a different specificity. The fusion protein is expressed by gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d19c797d8eabb28c3313f1fcd1ddb3
https://doi.org/10.1038/nbt0297-159
https://doi.org/10.1038/nbt0297-159
Publikováno v:
The Journal of Immunology. 158:733-740
Chimeric IgG3 lacking a genetic hinge but with Cys residues in CH2 between position 231 and 232 (IgG3 deltaH+Cys) and position 279 (IgG3 deltaH+2Cys) produced by site-directed mutagenesis have been found to be deficient in their intermolecular assemb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db05e28c2922ab0b54b653e590c695f7
https://doi.org/10.4049/jimmunol.158.2.733
https://doi.org/10.4049/jimmunol.158.2.733
Autor:
S. D. Putney, X Cao, P Lynch, J. P. McGrath, Ted Ebendal, S L Morrison, A. J. Schutz, M J Coloma
Publikováno v:
Journal of Neuroscience Research. 47:123-133
The cDNAs encoding the variable regions of the heavy and light chains of a murine antibody specific for the human TfR were cloned and a human chimera (gamma1, kappa) was produced. A gene fusion was created by joining the 3' end of the coding region o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::863814ed625d2fc2f8dcb069488a31f9
https://doi.org/10.1002/(sici)1097-4547(19970115)47:2<123::aid-jnr1>3.0.co
https://doi.org/10.1002/(sici)1097-4547(19970115)47:2<123::aid-jnr1>3.0.co
Publikováno v:
The Journal of Immunology. 154:2226-2236
The 18-amino acid carboxyl-terminal tailpiece from IgM (mutp) has now been added to the carboxyl-termini of IgG1, IgG2, IgG3, and IgG4 constant regions to produce recombinant IgM-like IgGs. Polymeric IgGs obtained by this approach possess up to six F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4bf0c5a69a715347db4f52a965bb0e8
https://doi.org/10.4049/jimmunol.154.5.2226
https://doi.org/10.4049/jimmunol.154.5.2226
Publikováno v:
Journal of Immunological Methods. 152:89-104
A new family of vectors has been produced which facilitates the cloning and expression of immunoglobulin variable regions cloned by polymerase chain reaction (PCR). The vectors are designed to express the cloned variable regions joined to human const
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a84c3c5c5cce46997eaee50313f79da4
https://doi.org/10.1016/0022-1759(92)90092-8
https://doi.org/10.1016/0022-1759(92)90092-8
Publikováno v:
Pharmaceutical research. 17(3)
Brain drug targeting may be achieved by conjugating drugs, that normally do not cross the blood-brain barrier (BBB), to brain drug delivery vectors. The murine 83-14 MAb to the human insulin receptor (HIR) is a potential brain drug targeting vector t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::090501cd5077fda5ebdb03a999cf8bae
https://pubmed.ncbi.nlm.nih.gov/10801214
https://pubmed.ncbi.nlm.nih.gov/10801214
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(4)
IgG is a glycoprotein with an N-linked carbohydrate structure attached to the CH2 domain of each of its heavy chains. In addition, the variable regions of IgG often contain potential N-linked carbohydrate addition sequences that frequently result in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d2b5ff821d2bb376bb6cb91f7df0c4ac
https://pubmed.ncbi.nlm.nih.gov/9973491
https://pubmed.ncbi.nlm.nih.gov/9973491
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 158(2)
Chimeric IgG3 lacking a genetic hinge but with Cys residues in CH2 between position 231 and 232 (IgG3 deltaH+Cys) and position 279 (IgG3 deltaH+2Cys) produced by site-directed mutagenesis have been found to be deficient in their intermolecular assemb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b792cd34aa27b955e4bce3dd8394d1a
https://pubmed.ncbi.nlm.nih.gov/8992989
https://pubmed.ncbi.nlm.nih.gov/8992989
Autor:
J P, McGrath, X, Cao, A, Schutz, P, Lynch, T, Ebendal, M J, Coloma, S L, Morrison, S D, Putney
Publikováno v:
Journal of neuroscience research. 47(2)
The cDNAs encoding the variable regions of the heavy and light chains of a murine antibody specific for the human TfR were cloned and a human chimera (gamma1, kappa) was produced. A gene fusion was created by joining the 3' end of the coding region o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::853f73c26676f6c191274ebc9fec97fc
https://pubmed.ncbi.nlm.nih.gov/9008143
https://pubmed.ncbi.nlm.nih.gov/9008143