Výsledky vyhledávání

Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities

Autor: M B Bailie, T J Standiford, L L Laichalk, M J Coffey, R Strieter, M Peters-Golden

Publikováno v: The Journal of Immunology. 157:5221-5224

Leukotrienes (LTs) are potent mediators of inflammation derived from the 5-lipoxygenase pathway of arachidonic acid metabolism. Although they are known to enhance leukocyte recruitment and function, their role in antimicrobial host defense has not be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::357dc61514cea8cc75cc3b03282d9be6
https://doi.org/10.4049/jimmunol.157.12.5221

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5-Lipoxygenase metabolism in alveolar macrophages from subjects infected with the human immunodeficiency virus

Autor: M J Coffey, S M Phare, P H Kazanjian, M Peters-Golden

Publikováno v: The Journal of Immunology. 157:393-399

Pulmonary infection represents a major source of morbidity and mortality in AIDS. One important component of pulmonary host defense is the elaboration by resident alveolar macrophages (AM) of proinflammatory leukotrienes (LT) and other 5-lipoxygenase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91fef7e104f02e197399c14c2d951e00
https://doi.org/10.4049/jimmunol.157.1.393

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Effects of granulocyte-macrophage colony-stimulating factor on eicosanoid production by mononuclear phagocytes

Autor: T G Brock, R W McNish, M J Coffey, T C Ojo, S M Phare, M Peters-Golden

Publikováno v: The Journal of Immunology. 156:2522-2527

Granulocyte-macrophage CSF (GM-CSF) primes granulocytes for leukotriene (LT) synthesis. Here, we examined the effects of GM-CSF on arachidonic acid (AA) metabolism in rat alveolar macrophages (AM), peritoneal macrophages, and human peripheral blood m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::507e943a2eb5b3d89e07cc168d41303f
https://doi.org/10.4049/jimmunol.156.7.2522

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Experimental and theoretical vibrational overtone spectra of vCH=3, 4, 5, and 6 in formaldehyde (H2CO)

Autor: M. D. Fritz, M. J. Coffey, F. Fleming Crim, D. Luckhaus

Publikováno v: The Journal of Chemical Physics. 104:3472-3478

We present the first photoacoustic absorption spectra of higher C–H stretching overtones in formaldehyde up to the visible spectral region. The analysis of the coarse rotational structure on the basis of asymmetric rotor simulations provides band c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8758e05a59471aa1f1532f51d7dd3efc
https://doi.org/10.1063/1.471537

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Peroxynitrite-induced nitrotyrosination of proteins is blocked by direct 5-lipoxygenase inhibitor zileuton

Autor: M J, Coffey, S M, Phare, M, Peters-Golden

Publikováno v: The Journal of pharmacology and experimental therapeutics. 299(1)

We have previously shown that the ability of overnight pretreatment with lipopolysaccharide (LPS) to suppress alveolar macrophage (AM) leukotrienes (LT) synthesis is explained by induction of nitric oxide (NO), and reactive oxygen intermediates (ROI)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d223b577efb55a173262d2f83d7e3f25
https://pubmed.ncbi.nlm.nih.gov/11561080

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Evidence for significant differences in microsomal drug glucuronidation by canine and human liver and kidney

Autor: M G, Soars, R J, Riley, K A, Findlay, M J, Coffey, B, Burchell

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 29(2)

The in vitro glucuronidation of a range of structurally diverse chemicals has been studied in hepatic and renal microsomes from human donors and the beagle dog. These studies were undertaken to improve on the limited knowledge of glucuronidation by t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c6eda08d4581322063a5394ac0df0510
https://pubmed.ncbi.nlm.nih.gov/11159800

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Granulocyte-macrophage colony-stimulating factor upregulates reduced 5-lipoxygenase metabolism in peripheral blood monocytes and neutrophils in acquired immunodeficiency syndrome

Autor: M J, Coffey, S M, Phare, S, Cinti, M, Peters-Golden, P H, Kazanjian

Publikováno v: Blood. 94(11)

Leukotrienes (LT) are mediators derived from the 5-lipoxygenase (5-LO) pathway, which play a role in host defense, and are synthesized by both monocytes (peripheral blood monocyte [PBM]) and neutrophils (PMN). Because 5-LO metabolism is reduced in al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2ab739a5b610044766b6d0a68fd37b2c
https://pubmed.ncbi.nlm.nih.gov/10572106

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TNF-alpha inhibits HIV-1 replication in peripheral blood monocytes and alveolar macrophages by inducing the production of RANTES and decreasing C-C chemokine receptor 5 (CCR5) expression

Autor: B R, Lane, D M, Markovitz, N L, Woodford, R, Rochford, R M, Strieter, M J, Coffey

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(7)

The pathogenesis of HIV-1 infection is influenced by the immunoregulatory responses of the host. Macrophages present in the lymphoid tissue are susceptible to infection with HIV-1, but are relatively resistant to its cytopathic effects and serve as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::57ced68d2f6d2616498f421a7d79ebf6
https://pubmed.ncbi.nlm.nih.gov/10490959

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