Výsledky vyhledávání - "M J, Casarejos"

Differential effects of l-DOPA on monoamine metabolism, cell survival and glutathione production in midbrain neuronal-enriched cultures from parkin knockout and wild-type mice

Autor: M J, Casarejos, R M, Solano, J, Menéndez, J A, Rodríguez-Navarro, C, Correa, J, García de Yébenes, M A, Mena

Publikováno v: Journal of neurochemistry. 94(4)

l-DOPA is the most effective treatment for Parkinson's disease but in isolated neuronal cultures it is neurotoxic for dopamine (DA) neurones. Experiments in vivo and clinical studies have failed to show toxicity of l-DOPA in animals or patients but t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e674d6c68efb510aa45bd90f4a9b3663
https://pubmed.ncbi.nlm.nih.gov/16000163

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[Glia conditioned medium offers protection against the toxicity induced by 6-OH-dopamine in vivo]

Autor: A, Rojo, M A, Mena-Gómez, A, Blázquez, M J, Casarejos, A, Fontán-Barreiro, J G, de Yébenes

Publikováno v: Revista de neurologia. 34(12)

Glia conditioned medium (GCM) is neurotrophic for dopaminergic (DA) neurons and protects against MPP+ toxicity in vitro. We present the data from the first study in vivo of the effects of GCM.The restorative effects were examined in rats with lesions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ee58819bb4c303ec693f8126388eec8e
https://pubmed.ncbi.nlm.nih.gov/12134273

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L-DOPA and glia-conditioned medium have additive effects on tyrosine hydroxylase expression in human catecholamine-rich neuroblastoma NB69 cells

Autor: E, Rodríguez-Martín, S, Canals, M J, Casarejos, S, de Bernardo, A, Handler, M A, Mena

Publikováno v: Journal of neurochemistry. 78(3)

The aim of this study was to investigate the effect of L-DOPA and glia-conditioned medium (GCM) on cell viability, tyrosine hydroxylase (TH) expression, dopamine (DA) metabolism and glutathione (GSH) levels of NB69 cells. L-DOPA (200 microM) induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6cf094c06abb75c310258dbaf827066d
https://pubmed.ncbi.nlm.nih.gov/11483656

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Neurotrophic and neurotoxic effects of nitric oxide on fetal midbrain cultures

Autor: S, Canals, M J, Casarejos, E, Rodríguez-Martín, S, de Bernardo, M A, Mena

Publikováno v: Journal of neurochemistry. 76(1)

There is evidence suggesting that nitric oxide (NO) may play an important role in dopamine (DA) cell death. Thus, the aim of this study was to investigate the effects of NO on apoptosis and functionality of DA neurones and glial cells. The experiment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::526830aaf6673bc0369c7a19275ca51d
https://pubmed.ncbi.nlm.nih.gov/11145978

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Akademický článek

Glia-conditioned medium induces de novo synthesis of tyrosine hydroxylase and increases dopamine cell survival by differential signaling pathways.

Autor: S. de Bernardo, S. Canals, M. J. Casarejos, E. Rodriguez-Martin, M. A. Mena

Publikováno v: Journal of Neuroscience Research; Sep2003, Vol. 73 Issue 6, p818, 13p

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Intracerebroventricular infusion of dopamine and its agonists in rodents and primates. An experimental approach to the treatment of Parkinson's disease

Autor: J, Garcia de Yebenes, S, Fahn, M A, Mena, B, Pardo, M J, Casarejos

Publikováno v: ASAIO transactions. 34(4)

The authors investigated the effects of chronic intracerebroventricular (ICV) infusion of dopamine (DA) and DA agonists in animal models of DA deficiency in rodents and primates. Rats with unilateral nigrostriatal lesions induced by 6-OH-DA received

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::408f850c0261921ec3fb470b4a2f0568
https://pubmed.ncbi.nlm.nih.gov/2905893

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