Zobrazeno 1 - 10
of 102
pro vyhledávání: '"M J, Brodie"'
Autor:
M. J. Brodie, R. Mohanraj
Publikováno v:
European Journal of Neurology. 13:277-282
Diagnosing refractory epilepsy would facilitate referral for specialist pharmacological review and early consideration of epilepsy surgery. An outcomes study was undertaken in an unselected cohort of newly diagnosed patients to determine the number o
Publikováno v:
Seizure. 5:41-46
An audit of patients receiving antiepileptic drug therapy for epilepsy was carried out in 25 general practices in Glasgow. Patients were identified from computerized records of repeat prescriptions for antiepileptic drugs. Overall, 1052 (0.72%) of 14
Autor:
M J, Brodie, M A, Dichter
Publikováno v:
New England Journal of Medicine. 334:168-175
Autor:
M. J. Brodie
Publikováno v:
Epilepsia. 35:S41-S46
Summary: With the launching worldwide of a range of new antiepileptic drugs (AEDs), the prescriber has a much wider choice than ever before. Comparative studies between new and established AEDs are few, and those between new AEDs are rarely performed
Autor:
R. A. Gillham, M. J. Brodie, G. Forrest, D. Connelly, S. M. Walker, P. J. W. Mckee, Jackie Blacklaw
Publikováno v:
British Journal of Clinical Pharmacology. 37:27-32
1. The effect of carbamazepine (CBZ), sodium valproate (VPA) and phenytoin (PHT) on the pharmacokinetics of oxcarbazepine (OXC) was explored in three groups of 12 epileptic patients taking one of these drug as monotherapy. 2. Each patient took a sing
Publikováno v:
Acta neurologica Scandinavica. 124(2)
Pregabalin (PGB) was licensed in Europe as an add-on antiepileptic drug (AED) for the treatment of partial-onset seizures in 2004. This audit assessed the response to adjunctive PGB in patients with uncontrolled seizures.PGB was titrated in 135 patie
Publikováno v:
British Journal of Clinical Pharmacology. 36:257-261
1. Fourteen patients with refractory epilepsy on a twice daily regimen of modified-release carbamazepine (CBZ-MR. Tegretol Retard. Ciba Pharmaceuticals) completed a balanced, double-blind, double dummy, random order, crossover comparison of 8 weeks t
Publikováno v:
Biochemical pharmacology. 30(17)
Human and rat liver microsomal fractions exhibit non-linear Michaelis-Menten kinetics in the O-deethylation of both phenacetin and 7-ethoxycoumarin. Comparison of various models indicated that the data were best described by a biphasic plot, which co
Publikováno v:
Epilepsia. 33:760-769
Summary: Dihydropyridine calcium antagonists are candidate anticonvulsants, but little is known of their penetration into brain. Nifedipine (NFD) and nimodipine (NMD) pharmacokinetics were compared in mouse blood and brain, and their activity against