Zobrazeno 1 - 10
of 20
pro vyhledávání: '"M J, Allalunis"'
Autor:
M J Allalunis-Turner, A J Franko, MB Parliament, R Mandyam, CL Santos, Peggy L. Olive, BG Wolokoff
Publikováno v:
British Journal of Cancer
We recently showed that severe hypoxia was not universally present adjacent to necrosis in human glioma xenografts and spheroids established from the M059K, M006, M006X, M006XLo and M010b cell lines. Using these glioma models, we wished to test wheth
Autor:
A M, Macann, R A, Britten, S, Poppema, R, Pearcey, E, Rosenberg, M J, Allalunis-Turner, D, Murray
Publikováno v:
Oncology reports. 7(2)
Follicle center cell lymphoma is among the most radioresponsive of human cancers. To assess whether this radioresponsiveness might be a result of a compromised ability of the tumor cells to accomplish the biologically-effective repair of DNA double-s
Publikováno v:
Anti-cancer drug design. 12(3)
Two series of hybrids of a dynemicin A model and DNA minor groove binding lexitropsins were synthesized and their cytotoxic activities were investigated in a panel of human normal and malignant cell lines using a colorimetric assay. Adriamycin was us
Publikováno v:
British Journal of Cancer
A cell-free plasmid reactivation assay was used to determine the fidelity of DNA double-strand break (DSB) repair in a panel of eight DSB repair-proficient human tumour cell lines. Nuclear protein extracts derived from radiosensitive tumour cells wer
Publikováno v:
Radiation research. 144(3)
The induction and repair of DNA double-strand breaks were studied in cells of two isogenic human malignant glioma cell lines which vary in their SF2 values by a factor of approximately 30. M059J cells are radiosensitive (SF2 = 0.02) and lack the p350
Publikováno v:
Cancer research. 54(22)
Recently, it has been shown that a gene encoding the cyclin-dependent kinase 4 inhibitory protein, p16, is frequently targeted for homozygous deletions in several types of tumor cell lines, including those established from malignant gliomas. Here we
Publikováno v:
Cancer research. 53(16)
Southern blot analyses of the 9p-localized type I interferon (IFN) genes in DNAs obtained from malignant glioma cell lines and glial tumor tissue have indicated that homozygous deletions of the IFN-alpha and IFN-beta genes often occur during the deve
Publikováno v:
Radiation research. 134(3)
Two aneuploid cell lines which differ in their inherent sensitivity to ionizing radiation and chemotherapeutic agents were established concurrently from a single tumor specimen obtained from a patient with glioblastoma. M059J cells are approximately
Autor:
R, Godbout, J, Miyakoshi, K D, Dobler, R, Andison, K, Matsuo, M J, Allalunis-Turner, H, Takebe, R S, Day
Publikováno v:
Oncogene. 7(9)
Human malignant gliomas (glioblastomas and anaplastic astrocytomas) are the most frequent brain tumors and are associated with a variety of genetic alterations including retinoblastoma (RB) and p53 gene mutations, loss of interferon alpha and beta (I
Autor:
M J, Allalunis-Turner
Publikováno v:
Radiation research. 122(3)
The sensitizer adduct technique [( 3H]misonidazole binding) was used to assess the extent of murine bone marrow hypoxia following treatment with a variety of radioprotectors. The binding rates previously determined in vivo were compared to those obta