Inhibition of Influenza Virus Replication by DNA Aptamers Targeting a Cellular Component of Translation Initiation

Autor: Paloma Rodriguez, M Isabel Pérez-Morgado, Víctor M Gonzalez, M Elena Martín, Amelia Nieto

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)

The genetic diversity of the influenza virus hinders the use of broad spectrum antiviral drugs and favors the appearance of resistant strains. Single-stranded DNA aptamers represent an innovative approach with potential application as antiviral compo

Externí odkaz: https://doaj.org/article/54a458c06c3241c39e9eca1565d2cff9

An Aptamer against MNK1 for Non-Small Cell Lung Cancer Treatment

Autor: Rebeca Carrión-Marchante, Celia Pinto-Díez, José Ignacio Klett-Mingo, Esther Palacios, Miriam Barragán-Usero, M. Isabel Pérez-Morgado, Manuel Pascual-Mellado, Sonia Alcalá, Laura Ruiz-Cañas, Bruno Sainz, Víctor M. González, M. Elena Martín

Publikováno v: Pharmaceutics, Vol 15, Iss 4, p 1273 (2023)

Lung cancer is the leading cause of cancer-related death worldwide. Its late diagnosis and consequently poor survival make necessary the search for new therapeutic targets. The mitogen-activated protein kinase (MAPK)-interacting kinase 1 (MNK1) is ov

Externí odkaz: https://doaj.org/article/bc742b1ea6d945ab905340e02546e4a7

DNA Aptamers against Vaccinia-Related Kinase (VRK) 1 Block Proliferation in MCF7 Breast Cancer Cells

Autor: M. Isabel Pérez-Morgado, M. Elena Martín, Valerio Frezza, Víctor M. González, Ana Salgado-Figueroa, Rebeca Carrión-Marchante

Publikováno v: Pharmaceuticals
Pharmaceuticals, Vol 14, Iss 473, p 473 (2021)
Volume 14
Issue 5

Vaccinia-related kinase (VRK) 1 is a serin/threonine kinase that plays an important role in DNA damage response (DDR), phosphorylating some proteins involved in this process such as 53BP1, NBS1 or H2AX, and in the cell cycle progression. In addition,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bccb6f7b46314a2d2200b8ddd3e66e8d
https://pubmed.ncbi.nlm.nih.gov/34067799

Characterization of MNK1b DNA Aptamers That Inhibit Proliferation in MDA-MB231 Breast Cancer Cells

Autor: M. Elena Martín, Marta García-Hernández, Gerónimo Fernández, Eva M. García-Recio, Celia Pinto-Díez, Víctor M. González, M. Isabel Pérez-Morgado

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Molecular Therapy. Nucleic Acids

Elevated expression levels of eukaryotic initiation factor 4E (eIF4E) promote cancer development and progression. MAP kinase interacting kinases (MNKs) modulate the function of eIF4E through the phosphorylation that is necessary for oncogenic transfo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fe65034c6c0d05317a50ec8594b3f2
http://www.sciencedirect.com/science/article/pii/S2162253116300117

Inhibition of Influenza Virus Replication by DNA Aptamers Targeting a Cellular Component of Translation Initiation

Autor: Amelia Nieto, M. Elena Martín, M. Isabel Pérez-Morgado, Víctor M. González, Paloma Rodriguez

Publikováno v: Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid

The genetic diversity of the influenza virus hinders the use of broad spectrum antiviral drugs and favors the appearance of resistant strains. Single-stranded DNA aptamers represent an innovative approach with potential application as antiviral compo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0573cb08749612d82fb8a028cf42c94f
https://pubmed.ncbi.nlm.nih.gov/27070300