Zobrazeno 1 - 10
of 65
pro vyhledávání: '"M I, Simon"'
Autor:
Keng Mean Lin, Dianne L. DeCamp, Paul C. Sternweis, M. I. Simon, Tamara I. A. Roach, Robert A. Rebres, William E. Seaman, Iain D. C. Fraser
Publikováno v:
Journal of Biological Chemistry. 283:17351-17361
Studies in fibroblasts, neurons, and platelets have demonstrated the integration of signals from different G protein-coupled receptors (GPCRs) in raising intracellular free Ca(2+). To study signal integration in macrophages, we screened RAW264.7 cell
COS-1, a putative two-component histidine kinase of Candida albicans, is an in vivo virulence factor
Publikováno v:
Medical Mycology. 39:69-74
Publikováno v:
Journal of Raman Spectroscopy. 30:785-793
The development of a surface-enhanced Raman scattering (SERS) method and instrument for use in biomedical and genomics analysis is described. The technology uses DNA gene probes based on SERS labels for gene detection and DNA mapping. The detection m
Publikováno v:
The EMBO Journal. 15:3880-3889
We have used PCR to identify a Dictyostelium homolog of the bacterial two-component system. The gene dokA codes for a member of the hybrid histidine kinase family which is defined by the presence of conserved amino acid sequence motifs corresponding
Publikováno v:
Journal of Biological Chemistry. 269:22150-22156
The beta-subunits of the heterotrimeric GTP-binding proteins (G-proteins) are important regulators of G-protein alpha-subunits as well as of certain signal transduction receptors and effectors. We have identified a fifth member of the G-protein beta-
Publikováno v:
Journal of Biological Chemistry. 267:16044-16047
The relative specificities of members of the G alpha q family of GTP-binding proteins were tested for their ability to activate different phosphoinositide-specific phospholipase C (PI-PLC) beta isozymes. Cos-7 cells were transfected with cDNA corresp
Publikováno v:
Proceedings of the National Academy of Sciences. 93:6228-6230
In the seventeenth century, Antoine von Leeuwenhook used a simple microscope to discover that we live within a previously undetected microbial world containing an enormously diverse population of creatures. The late nineteenth and early twentieth cen
Publikováno v:
Aktuelle Neurologie. 31
Autor:
U.-J. Kim, M. I. Simon
We developed a great deal of expertise in building large BAC libraries from a variety of DNA sources including humans, mice, corn, microorganisms, worms, and Arabidopsis. We greatly improved the technology for screening these libraries rapidly and fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e5c0c07c7a688db8ad8f524ae2d47fb
https://doi.org/10.2172/791968
https://doi.org/10.2172/791968
COS-l, a putative two-component histidine kinase of Candida albicans, is an in vivo virulence factor
Publikováno v:
Medical mycology. 39(1)
The human fungal pathogen, Candida albicans, has three putative histidine kinases showing homology to those of plants, bacteria and other fungi. We have constructed a homozygous deletion strain and a hemizygous reconstituted strain of one of these hi