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PANORAMA: An Integrated Web-Based Sequence Analysis Tool and Its Role in Gene Discovery

Autor: A, Pertsemlidis, A, Pande, B, Miller, P, Schilling, M H, Wei, M I, Lerman, J D, Minna, H R, Garner, D, Mittelman

Publikováno v: Genomics. 70:300-306

As the exponential growth of DNA sequence information in databases continues, the task of converting this deposited information into knowledge becomes more dependent on integrative sequence analysis and visualization tools. PANORAMA is an Internet-ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35d71cfc33a88dd81500c9a31f34f17
https://doi.org/10.1006/geno.2000.6359

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Colocalization of the rat homolog of the von Hippel Lindau (Vhl) gene and the plasma membrane Ca++ transporting ATPase isoform 2 (Atp2b2) gene to rat chromosome bands 4q41.3→42.1

Autor: David Trono, R. S. Yeung, Claudio M Aldaz, M. I. Lerman, Cheryl L. Walker, F. Latif, G. Xiao

Publikováno v: Cytogenetic and Genome Research. 71:253-256

Using fluorescence in situ hybridization, we localized the rat homolog of the von Hippel-Lindau gene (Vhl) to rat chromosome band 4q41.3→q42.1. We also mapped the gene encoding the plasma membrane Ca++-transporting ATPase iso-form 2 (Atp2b2) to the

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https://doi.org/10.1159/000134121

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Carbonic anhydrase 9 as an endogenous marker for hypoxic cells in cervical cancer

Autor: P L, Olive, C, Aquino-Parsons, S H, MacPhail, S Y, Liao, J A, Raleigh, M I, Lerman, E J, Stanbridge

Publikováno v: Cancer research. 61(24)

The presence of radiation-resistant hypoxic cells in some solid tumors is known to predict for relapse after radiotherapy. Use of an endogenous marker of hypoxia would be a convenient alternative to current methods that measure tumor oxygenation, pro

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https://pubmed.ncbi.nlm.nih.gov/11751418

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The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium

Autor: M I, Lerman, J D, Minna

Publikováno v: Cancer research. 60(21)

We used overlapping and nested homozygous deletions, contig building, genomic sequencing, and physical and transcript mapping to further define a approximately 630-kb lung cancer homozygous deletion region harboring one or more tumor suppressor genes

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https://pubmed.ncbi.nlm.nih.gov/11085536

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High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints

Autor: I I, Wistuba, C, Behrens, A K, Virmani, G, Mele, S, Milchgrub, L, Girard, J W, Fondon, H R, Garner, B, McKay, F, Latif, M I, Lerman, S, Lam, A F, Gazdar, J D, Minna

Publikováno v: Cancer research. 60(7)

Allele loss involving chromosome arm 3p is one of the most frequent and earliest known genetic events in lung cancer pathogenesis and may affect several potential tumor suppressor gene regions. To further study the role of chromosome 3p allele loss i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::78370698d345ddcf236fe6fe73d1ebc8
https://pubmed.ncbi.nlm.nih.gov/10766185

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A functional investigation of tumor suppressor gene activities in a nasopharyngeal carcinoma cell line HONE1 using a monochromosome transfer approach

Autor: Y, Cheng, E J, Stanbridge, H, Kong, U, Bengtsson, M I, Lerman, M L, Lung

Publikováno v: Genes, chromosomescancer. 28(1)

Monochromosome transfers of selected chromosomes into a nasopharyngeal carcinoma (NPC) cell line were performed to determine if tumor suppressing activity for NPC mapped to chromosomes 9, 11, and 17. Current information from cytogenetic and molecular

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https://pubmed.ncbi.nlm.nih.gov/10738306

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Constitutional von Hippel-Lindau (VHL) gene deletions detected in VHL families by fluorescence in situ hybridization

Autor: S D, Pack, B, Zbar, E, Pak, D O, Ault, J S, Humphrey, T, Pham, K, Hurley, R J, Weil, W S, Park, I, Kuzmin, C, Stolle, G, Glenn, L A, Liotta, M I, Lerman, R D, Klausner, W M, Linehan, Z, Zhuang

Publikováno v: Cancer research. 59(21)

von Hippel-Lindau (VHL) disease is an autosomal dominantly inherited cancer syndrome predisposing to a variety of tumor types that include retinal hemangioblastomas, hemangioblastomas of the central nervous system, renal cell carcinomas, pancreatic c

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https://pubmed.ncbi.nlm.nih.gov/10554035

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CALL gene is haploinsufficient in a 3p- syndrome patient

Autor: D, Angeloni, N M, Lindor, S, Pack, F, Latif, M H, Wei, M I, Lerman

Publikováno v: American journal of medical genetics. 86(5)

The 3p- syndrome results from deletion of a terminal segment of the short arm of one chromosome 3 (3p25--pter), and is characterized by multiple congenital anomalies and mental retardation. Due to its variable expression, it is assumed this disorder

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https://pubmed.ncbi.nlm.nih.gov/10508992

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Polymerase chain reaction-single-strand conformation polymorphism analysis for the VHL gene in chemically induced kidney tumors of rats using intron-derived primers

Autor: Y H, Shiao, B A, Diwan, A O, Perantoni, R J, Calvert, B, Zbar, M I, Lerman, J M, Rice

Publikováno v: Molecular carcinogenesis. 19(4)

von Hippel-Lindau (VHL) gene mutations occur throughout three exons including the exon-intron boundaries in human VHL disease-associated and sporadic renal cell carcinomas. To explore the possible role of the VHL gene in chemically induced rat kidney

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https://pubmed.ncbi.nlm.nih.gov/9290699

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Localization of the human vascular endothelial growth factor gene, VEGF, at chromosome 6p12

Autor: M H, Wei, N C, Popescu, M I, Lerman, M J, Merrill, D B, Zimonjic

Publikováno v: Human genetics. 97(6)

Using overlapping cosmids representing the vascular endothelial growth factor (VEGF) locus, the VEGF gene was mapped by fluorescence in situ hybridization to chromosome 6p12. This localization permits linkage analysis and the identification of gene i

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https://pubmed.ncbi.nlm.nih.gov/8641698

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