Structure-based analysis of CysZ-mediated cellular uptake of sulfate

Autor: Zahra Assur Sanghai, Qun Liu, Oliver B Clarke, Meagan Belcher-Dufrisne, Pattama Wiriyasermkul, M Hunter Giese, Edgar Leal-Pinto, Brian Kloss, Shantelle Tabuso, James Love, Marco Punta, Surajit Banerjee, Kanagalaghatta R Rajashankar, Burkhard Rost, Diomedes Logothetis, Matthias Quick, Wayne A Hendrickson, Filippo Mancia

Publikováno v: eLife, Vol 7 (2018)

Sulfur, most abundantly found in the environment as sulfate (SO42-), is an essential element in metabolites required by all living cells, including amino acids, co-factors and vitamins. However, current understanding of the cellular delivery of SO42-

Externí odkaz: https://doaj.org/article/ab715dc2d4de43f39a8bdcbb5e334127

Voltage-gated potassium channels (Kv) in GtoPdb v.2023.1

Autor: Xiaoliang Wang, James S. Trimmer, Walter Stühmer, Michael C. Sanguinetti, Bernardo Rudy, Gail A. Robertson, Luis A. Pardo, Jeanne Nerbonne, David Mckinnon, Michel Lazdunski, Lily Y. Jan, George A. Gutman, Stephan Grissmer, M. Hunter Giese, K. George Chandy, Bernard Attali

Publikováno v: IUPHAR/BPS Guide to Pharmacology CITE. 2023

The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels possess a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99aca55f8983c389a3f91071d3c86ebc
https://doi.org/10.2218/gtopdb/f81/2023.1

Gating movements and ion permeation in HCN4 pacemaker channels

Autor: Anna Moroni, Wayne A. Hendrickson, Giacomo Parisi, Dario DiFrancesco, Martino Bolognesi, Federica Gasparri, Atiyeh Sadat Sharifzadeh, Bina Santoro, Alessandro Porro, Antonio Chaves-Sanjuan, Oliver B. Clarke, Filippo Mancia, Paolo Swuec, Andrea Saponaro, Gabriele Cerutti, M. Hunter Giese, Henry M. Colecraft, Daniel Bauer, Laura Alberio, Gerhard Thiel, Kay Hamacher, Steven A. Siegelbaum

Publikováno v: Molecular Cell
Molecular cell (Online) 81 (2021): 2929–2943.e6. doi:10.1016/j.molcel.2021.05.033
info:cnr-pdr/source/autori:Saponaro A.; Bauer D.; Giese M.H.; Swuec P.; Porro A.; Gasparri F.; Sharifzadeh A.S.; Chaves-Sanjuan A.; Alberio L.; Parisi G.; Cerutti G.; Clarke O.B.; Hamacher K.; Colecraft H.M.; Mancia F.; Hendrickson W.A.; Siegelbaum S.A.; DiFrancesco D.; Bolognesi M.; Thiel G.; Santoro B.; Moroni A./titolo:Gating movements and ion permeation in HCN4 pacemaker channels/doi:10.1016%2Fj.molcel.2021.05.033/rivista:Molecular cell (Online)/anno:2021/pagina_da:2929/pagina_a:2943.e6/intervallo_pagine:2929–2943.e6/volume:81

Summary The HCN1–4 channel family is responsible for the hyperpolarization-activated cation current If/Ih that controls automaticity in cardiac and neuronal pacemaker cells. We present cryoelectron microscopy (cryo-EM) structures of HCN4 in the pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903d45cee06d6ee9593f1bb42b7ccfab
https://doi.org/10.1016/j.molcel.2021.05.033

Single-channel recordings of RyR1 at microsecond resolution in CMOS-suspended membranes

Autor: Indra Schroeder, Andreas J.W. Hartel, Andrew R. Marks, Peijie Ong, Oliver B. Clarke, M. Hunter Giese, Ran Zalk, Siddharth Shekar, Wayne A. Hendrickson, Kenneth L. Shepard

Publikováno v: Proceedings of the National Academy of Sciences

Single-channel recordings are widely used to explore functional properties of ion channels. Typically, such recordings are performed at bandwidths of less than 10 kHz because of signal-to-noise considerations, limiting the temporal resolution availab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3375d8f5e04bd9f206750475a4eb53e4

CMOS-Integrated Electrophysiology and Data Analysis by Extended BETA Distributions Reveal Nanosecond Closed State Flickering of the TYPE-1 Ryanodine Receptor

Autor: Oliver B. Clarke, Wayne A. Hendrickson, Siddharth Shekar, Peijie Ong, Kenneth L. Shepard, M. Hunter Giese, Andrew R. Marks, Andreas J.W. Hartel, Indra Schröder

Publikováno v: Biophysical Journal. 114:129a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85275d8514c3171a5b5df9ca838ee02f
https://doi.org/10.1016/j.bpj.2017.11.732