Zobrazeno 1 - 10
of 895
pro vyhledávání: '"M Holter"'
Publikováno v:
Pharmaceuticals, Vol 17, Iss 2, p 237 (2024)
Sex- and age-related differences in symptom prevalence and severity have been widely reported in patients with schizophrenia, yet the underlying mechanisms contributing to these differences are not well understood. N-methyl-D-aspartate (NMDA) recepto
Externí odkaz:
https://doaj.org/article/8d580c16c76248a9a7da302f4dbecf9c
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
As an incretin hormone, glucagon-like peptide 1 (GLP-1) lowers blood glucose levels by enhancing glucose-stimulated insulin secretion from pancreatic beta-cells. Therapies targeting the GLP-1 receptor (GLP-1R) use the classical incretin model as a ph
Externí odkaz:
https://doaj.org/article/2cd53a8838c742bdbd5a056e2f5d1475
Publikováno v:
Journal of Infrastructure Preservation and Resilience, Vol 1, Iss 1, Pp 1-28 (2020)
Abstract The protection of underground civil infrastructure continues to be a high priority for transportation and transit security agencies. In particular, rail transit tunnels running under bodies of water are susceptible to disruptions due to floo
Externí odkaz:
https://doaj.org/article/7da123f8935e4db7aa08c6487f13ab8e
Autor:
Kimberly M. Holter, Alex D. Lekander, Christina M. LaValley, Elizabeth G. Bedingham, Bethany E. Pierce, L. Paul Sands, Craig W. Lindsley, Carrie K. Jones, Robert W. Gould
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Selective negative allosteric modulators (NAMs) targeting the metabotropic glutamate receptor subtype 5 (mGlu5) demonstrate anxiolytic-like and antidepressant-like effects yet concern regarding adverse effect liability remains. Functional coupling of
Externí odkaz:
https://doaj.org/article/0a0ae44e0f6442668ba0e76ba53e03d1
Autor:
Mridusmita Saikia, Marlena M. Holter, Leanne R. Donahue, Isaac S. Lee, Qiaonan C. Zheng, Journey L. Wise, Jenna E. Todero, Daryl J. Phuong, Darline Garibay, Reilly Coch, Kyle W. Sloop, Adolfo Garcia-Ocana, Charles G. Danko, Bethany P. Cummings
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that potentiates glucose-stimulated insulin secretion. GLP-1 is classically produced by gut L cells; however, under certain circumstances α cells can express the prohormone convertase required f
Externí odkaz:
https://doaj.org/article/d8231da5c1ae478aaa15444e8576fb6f
Publikováno v:
American Journal of Veterinary Research. :1-8
OBJECTIVE To compare plasma concentrations of glucagon and glucagon-like peptide-1 (GLP-1) between healthy dogs and dogs with aminoaciduric canine hypoaminoacidemic hepatopathy syndrome (ACHES) dogs. ANIMALS Privately owned healthy (n = 5) control (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de933d5b0214ed3fb1572451cd19f174
https://doi.org/10.2460/ajvr.22.10.0174
https://doi.org/10.2460/ajvr.22.10.0174
Publikováno v:
International Review of Neurobiology ISBN: 9780323993944
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4609215cce9c5811156506fe36208817
https://doi.org/10.1016/bs.irn.2022.11.002
https://doi.org/10.1016/bs.irn.2022.11.002
Publikováno v:
Nutrients, Vol 12, Iss 9, p 2598 (2020)
TGR5 is a G protein-coupled bile acid receptor that is increasingly recognized as a key regulator of glucose homeostasis. While the role of TGR5 signaling in immune cells, adipocytes and enteroendocrine L cells in metabolic regulation has been well d
Externí odkaz:
https://doaj.org/article/927e4e924c9543008e0eee554f609938
Autor:
Marlena M. Holter, Margot K. Chirikjian, Daniel A. Briere, Adriano Maida, Kyle W. Sloop, Kristina Schoonjans, Bethany P. Cummings
Publikováno v:
Nutrients, Vol 12, Iss 7, p 2124 (2020)
The bile acid receptor, TGR5, is a key regulator of glucose homeostasis, but the mechanisms by which TGR5 signaling improves glucose regulation are incompletely defined. In particular, TGR5 has an increasingly appreciated role in liver physiology and
Externí odkaz:
https://doaj.org/article/3ceb5c5f3e284605b0951f3a761c06c6
Autor:
Marlena M. Holter, Daryl J. Phuong, Isaac Lee, Mridusmita Saikia, Lisa Weikert, Samantha Fountain, Elizabeth T. Anderson, Qin Fu, Sheng Zhang, Kyle W. Sloop, Bethany P. Cummings
Publikováno v:
Science advances. 8(29)
Recent studies demonstrate that α cells contribute to glucose-stimulated insulin secretion (GSIS). Glucagon-like peptide-1 receptor (GLP-1R) agonists potently potentiate GSIS, making these drugs useful for diabetes treatment. However, the role of α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc96e0fcd137f10601a82fcf3986187
https://pubmed.ncbi.nlm.nih.gov/35867787
https://pubmed.ncbi.nlm.nih.gov/35867787