Zobrazeno 1 - 10
of 575
pro vyhledávání: '"M Hocking"'
Autor:
Leonie G. Graf, Carlos Moreno-Yruela, Chuan Qin, Sabrina Schulze, Gottfried J. Palm, Ole Schmöker, Nancy Wang, Dianna M. Hocking, Leila Jebeli, Britta Girbardt, Leona Berndt, Babett Dörre, Daniel M. Weis, Markus Janetzky, Dirk Albrecht, Daniela Zühlke, Susanne Sievers, Richard A. Strugnell, Christian A. Olsen, Kay Hofmann, Michael Lammers
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-31 (2024)
Abstract Classical Zn2+-dependent deac(et)ylases play fundamental regulatory roles in life and are well characterized in eukaryotes regarding their structures, substrates and physiological roles. In bacteria, however, classical deacylases are less we
Externí odkaz:
https://doaj.org/article/ccf2c27a6704404393014ebb3e735864
Autor:
Sarah Alice Long, Virginia S. Muir, Britta E. Jones, Valerie Z. Wall, Alyssa Ylescupidez, Anne M. Hocking, Stephan Pribitzer, Jerill Thorpe, Bryce Fuchs, Alice E. Wiedeman, Megan Tatum, Katharina Lambert, Hannes Uchtenhagen, Cate Speake, Bernard Ng, Alexander T. Heubeck, Troy R. Torgerson, Adam K. Savage, Michael A. Maldonado, Neelanjana Ray, Vadim Khaychuk, Jinqi Liu, Peter S. Linsley, Jane H. Buckner
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Exhausted CD8 T cells (TEX) are associated with worse outcome in cancer yet better outcome in autoimmunity. Building on our past findings of increased TIGIT+KLRG1+ TEX with teplizumab therapy in type 1 diabetes (T1D), in the absence of treatment we f
Externí odkaz:
https://doaj.org/article/848afa4859044e9fb280078686f378e7
Autor:
Nancy Wang, Timothy A Scott, Andreas Kupz, Meghanashree M Shreenivas, Newton G Peres, Dianna M Hocking, Chenying Yang, Leila Jebeli, Lynette Beattie, Joanna R Groom, Thomas P Pierce, Linda M Wakim, Sammy Bedoui, Richard A Strugnell
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011666 (2023)
Prior infection can generate protective immunity against subsequent infection, although the efficacy of such immunity can vary considerably. Live-attenuated vaccines (LAVs) are one of the most effective methods for mimicking this natural process, and
Externí odkaz:
https://doaj.org/article/f3d56009cb644d75a2d9d9ab1727aad4
Autor:
Cate Speake, Tania Habib, Katharina Lambert, Christian Hundhausen, Sandra Lord, Matthew J. Dufort, Samuel O. Skinner, Alex Hu, MacKenzie Kinsman, Britta E. Jones, Megan D. Maerz, Megan Tatum, Anne M. Hocking, Gerald T. Nepom, Carla J. Greenbaum, Jane H. Buckner
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
Therapeutics that inhibit IL-6 at different points in its signaling pathway are in clinical use, yet whether the immunological effects of these interventions differ based on their molecular target is unknown. We performed short-term interventions in
Externí odkaz:
https://doaj.org/article/0d42c57eea354a0694720ed4803ef101
Autor:
Anne M. Hocking, Jane H. Buckner
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Genetic variants associated with susceptibility to autoimmune disease have provided important insight into the mechanisms responsible for the loss of immune tolerance and the subsequent development of autoantibodies, tissue damage, and onset of clini
Externí odkaz:
https://doaj.org/article/3a0ad08f2b4f49fab9ca5e8505062f96
Autor:
Katharina Lambert, Kirsten E. Diggins, Britta E. Jones, Christian Hundhausen, Megan D. Maerz, Anne M. Hocking, Srinath Sanda, Carla J. Greenbaum, Peter S. Linsley, Karen Cerosaletti, Jane H. Buckner
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Elevated levels and enhanced sensing of the pro-inflammatory cytokine interleukin-6 (IL-6) are key features of many autoimmune and inflammatory diseases. To better understand how IL-6 signaling may influence human T cell fate, we investigated the rel
Externí odkaz:
https://doaj.org/article/c773700586e44a7c8cb9899ec2c188f9
Autor:
Androniki Psifidi, Andreas Kranis, Lisa M. Rothwell, Abi Bremner, Kay Russell, Diego Robledo, Stephen J. Bush, Mark Fife, Paul M. Hocking, Georgios Banos, David A. Hume, Jim Kaufman, Richard A. Bailey, Santiago Avendano, Kellie A. Watson, Pete Kaiser, Mark. P. Stevens
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Campylobacter is the leading cause of bacterial foodborne gastroenteritis worldwide. Handling or consumption of contaminated poultry meat is a key risk factor for human campylobacteriosis. One potential control strategy is to select poultry
Externí odkaz:
https://doaj.org/article/7e1f6472c34c49b9b1c83a773c652d42
Publikováno v:
Mobile DNA, Vol 11, Iss 1, Pp 1-13 (2020)
Abstract Background Endogenous retroviruses (ERVs) are the remnants of retroviral infections which can elicit prolonged genomic and immunological stress on their host organism. In chickens, endogenous Avian Leukosis Virus subgroup E (ALVE) expression
Externí odkaz:
https://doaj.org/article/4a382f3324db4fd79c73593e25bcb751
Autor:
Raman Akinyanju Lawal, Simon H. Martin, Koen Vanmechelen, Addie Vereijken, Pradeepa Silva, Raed Mahmoud Al-Atiyat, Riyadh Salah Aljumaah, Joram M. Mwacharo, Dong-Dong Wu, Ya-Ping Zhang, Paul M. Hocking, Jacqueline Smith, David Wragg, Olivier Hanotte
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-18 (2020)
Abstract Background Hybridisation and introgression play key roles in the evolutionary history of animal species. They are commonly observed within several orders in wild birds. The domestic chicken Gallus gallus domesticus is the most common livesto
Externí odkaz:
https://doaj.org/article/dd711d0b7cbb49de9f17f37b59e83755
Autor:
Theodore Green, Sarah P. Slotznick, Plinio Jaqueto, Timothy D. Raub, Eric Tohver, Ted E. Playton, Peter W. Haines, Joseph L. Kirschvink, Roger M. Hocking, Paul Montgomery
Publikováno v:
Frontiers in Earth Science, Vol 9 (2021)
Late Devonian time was a period of rapid upheaval in the Earth system, including climate change, sea level changes, widespread ocean anoxia, and the Frasnian-Famennian mass extinction; the cause(s) of these changes remain(s) uncertain. The Lennard Sh
Externí odkaz:
https://doaj.org/article/64a707a7ade344c18a4afe9fc8c0c683