Schizophrenia-associated differential DNA methylation in brain is distributed across the genome and annotated to MAD1L1, a locus at which DNA methylation and transcription phenotypes share genetic variation with schizophrenia risk

Autor: Brandon C. McKinney, Lora L. McClain, Christopher M. Hensler, Yue Wei, Lambertus Klei, David A. Lewis, Bernie Devlin, Jiebiao Wang, Ying Ding, Robert A. Sweet

Publikováno v: Translational Psychiatry, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract DNA methylation (DNAm), the addition of a methyl group to a cytosine in DNA, plays an important role in the regulation of gene expression. Single-nucleotide polymorphisms (SNPs) associated with schizophrenia (SZ) by genome-wide association s

Externí odkaz: https://doaj.org/article/77d4e847a2344926bcf4c29de2d71243

Additive Effects of Omega-3 Fatty Acids and Thiazolidinediones in Mice Fed a High-Fat Diet: Triacylglycerol/fatty Acid Cycling in Adipose Tissue

Autor: Olga Horakova, Jan Kopecky, Jiri Funda, Katerina Adamcova, Petra Janovska, Ilaria Irodenko, Lucie Lenkova, Petr Zouhar, Martin Rossmeisl, Radek Pohl, Tomas Cajka, Pavel Flachs, M Hensler, Ondrej Kuda, Jerry R. Colca, Kristina Bardova

Publikováno v: Nutrients, Vol 12, Iss 3737, p 3737 (2020)
Nutrients
Volume 12
Issue 12

Long-chain n-3 polyunsaturated fatty acids (Omega-3) and anti-diabetic drugs thiazolidinediones (TZDs) exhibit additive effects in counteraction of dietary obesity and associated metabolic dysfunctions in mice. The underlying mechanisms need to be cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fdd431dbb786e559d8952477f9af971
https://www.mdpi.com/2072-6643/12/12/3737

Early differences in metabolic flexibility between obesity-resistant and obesity-prone mice

Autor: Kristina Bardova, Petra Janovska, Olga Horakova, Melissa Uil, Jana Hansikova, Jan Kopecky, Femke P. M. Hoevenaars, Vladimir Kus, Jaap Keijer, Evert M. van Schothorst, M Hensler

Publikováno v: Biochimie 124 (2016)
Biochimie, 124, 163-170

Decreased metabolic flexibility, i.e. a compromised ability to adjust fuel oxidation to fuel availability supports development of adverse consequences of obesity. The aims of this study were (i) to learn whether obesity-resistant A/J and obesity-pron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d534ae0ee912c6fba7030bb5091a38ff
https://doi.org/10.1016/j.biochi.2015.11.014

Omega-3 phospholipids from fish suppress hepatic steatosis by integrated inhibition of biosynthetic pathways in dietary obese mice

Autor: Barbora Stankova, Kristina Bardova, Pavel Flachs, Jaap Keijer, Jana Pavlisova, Evert M. van Schothorst, M Hensler, Marek Vecka, Dasa Medrikova, Ondrej Kuda, Ales Zak, Jan Kopecky, Martin Rossmeisl, Eva Tvrzická

Publikováno v: Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids 1841 (2014) 2
Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1841(2), 267-278

Non-alcoholic fatty liver disease (NAFLD) accompanies obesity and insulin resistance. Recent meta-analysis suggested omega-3 polyunsaturated fatty acids DHA and EPA to decrease liver fat in NAFLD patients. Anti-inflammatory, hypolipidemic, and insuli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ebcf786a8cf1d73297fc0b639e7555
https://doi.org/10.1016/j.bbalip.2013.11.010

AMP-activated Protein Kinase α2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids

Autor: Thomas E. Jensen, Jan Kopecky, Martin Rossmeisl, Ivan Mikšík, Simon A. Hawley, Marcin Baranowski, Pavel Flachs, Vladimir Kus, Petra Janovska, Zuzana Macek Jilkova, Benoit Viollet, Ondrej Kuda, Dasa Medrikova, Sophie Hébrard, Jan Górski, Tomas Jelenik, M Hensler

Publikováno v: Diabetes

OBJECTIVE The induction of obesity, dyslipidemia, and insulin resistance by high-fat diet in rodents can be prevented by n-3 long-chain polyunsaturated fatty acids (LC-PUFAs). We tested a hypothesis whether AMP-activated protein kinase (AMPK) has a r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20cb3b56af9371526dfc268b726bf308
http://europepmc.org/articles/PMC2963531